Metadata

Name Diabetic ophthalmic complications (diab_eye)
Category Eye
Sex
Adult Yes
UUID e7e4b350-adc5-4b71-ac0c-dc08d92c4aff
Definition Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.

Ontologies

Disease Ontology (DOID) DOID_13207
GWAS Catalogue EFO_0003770
MeSH D003930
SNOMED-CT 25093002
FinnGen H7_RETINOPATHYDIAB_ADVANC

Key Summary Statistics

Cases from any source

Total 13313
Female (%) 5066 (38%)
Male (%) 8247 (62%)

Year first recorded

diab_eye year of first event

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Cross-sourced diab_eye cases

Incidence & prevalence

Sex and age-stratified incidence and prevalence of diab_eye

Baseline prevalence stratified by sex

Female 98.9 (92.24,105.56)
Male 216.43 (205.76,227.1)

Incidence stratified by sex

Female 19.67 (18.51,20.83)
Male 40.45 (38.61,42.29)

Incidence stratified by age

Ages 40-44 11.77 (9.63,13.91)
Ages 45-49 17.96 (15.69,20.24)
Ages 50-54 23.72 (21.29,26.14)
Ages 55-59 27.68 (25.31,30.06)
Ages 60-64 34.74 (32.44,37.03)
Ages 65-69 43.65 (40.69,46.61)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

CALIBER and UKB diab_eye prevalence comparison for multiple age groups

Population Ages 40-49 Ages 50-59 Ages 60-69
UK Biobank 160 (147,173) 278 (266,292) 415 (402,428)
CALIBER 121 (118,124) 252 (248,257) 424 (418,431)

Stratified by age and Townsend deprivation status

Deprivation status Ages 40-49 Ages 50-59 Ages 60-69
Least deprived 89(68,114) 182(159,208) 306(282,332)
Low 105(82,132) 202(177,229) 339(314,367)
Medium 126(102,155) 242(215,271) 377(349,406)
High 178(151,209) 296(267,328) 448(416,481)
Most deprived 254(224,286) 458(422,496) 649(610,691)

Stratified by age and country

Country Ages 40-49 Ages 50-59 Ages 60-69
England 168(154,182) 279(264,294) 415(400,430)
Scotland 135(103,172) 282(247,320) 411(372,452)
Wales 113(78,159) 268(225,318) 422(375,474)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153508, Events=407

Factor Level Hazard Ratio P value
BMI overweight 0.96 (0.75, 1.22) 0.716
BMI obese 1.36 (1.06, 1.76) 0.0167
BMI underweight 0 (0, Inf) 0.986
smoking previous 1.37 (1.1, 1.7) 0.00438
smoking current 2.14 (1.6, 2.85) 2.26e-07
hypertension yes 1.88 (1.53, 2.31) 1.47e-09

Risk factors analysis forest plot

Definition

UK Biobank field id Description Code Value
20002 Non-cancer illness code, self-reported 1276 diabetic eye disease
41202 Diagnoses - main ICD10 H35.0 Background retinopathy and retinal vascular changes
41202 Diagnoses - main ICD10 H35.2 Other proliferative retinopathy
41202 Diagnoses - main ICD10 E10.3 Insulin-dependent diabetes mellitus - With ophthalmic complications
41202 Diagnoses - main ICD10 E11.3 Non-insulin-dependent diabetes mellitus - With ophthalmic complications
41202 Diagnoses - main ICD10 E12.3 Malnutrition-related diabetes mellitus - With ophthalmic complications
41202 Diagnoses - main ICD10 E13.3 Other specified diabetes mellitus - With ophthalmic complications
41202 Diagnoses - main ICD10 E14.3 Unspecified diabetes mellitus - With ophthalmic complications
41202 Diagnoses - main ICD10 H28.0 Diabetic cataract
41202 Diagnoses - main ICD10 H36.0 Diabetic retinopathy
41204 Diagnoses - secondary ICD10 H35.0 Background retinopathy and retinal vascular changes
41204 Diagnoses - secondary ICD10 H35.2 Other proliferative retinopathy
41204 Diagnoses - secondary ICD10 E10.3 Insulin-dependent diabetes mellitus - With ophthalmic complications
41204 Diagnoses - secondary ICD10 E11.3 Non-insulin-dependent diabetes mellitus - With ophthalmic complications
41204 Diagnoses - secondary ICD10 E12.3 Malnutrition-related diabetes mellitus - With ophthalmic complications
41204 Diagnoses - secondary ICD10 E13.3 Other specified diabetes mellitus - With ophthalmic complications
41204 Diagnoses - secondary ICD10 E14.3 Unspecified diabetes mellitus - With ophthalmic complications
41204 Diagnoses - secondary ICD10 H28.0 Diabetic cataract
41204 Diagnoses - secondary ICD10 H36.0 Diabetic retinopathy
40001 Underlying (primary) cause of death: ICD10 H35.0 Background retinopathy and retinal vascular changes
40001 Underlying (primary) cause of death: ICD10 H35.2 Other proliferative retinopathy
40001 Underlying (primary) cause of death: ICD10 E10.3 Insulin-dependent diabetes mellitus - With ophthalmic complications
40001 Underlying (primary) cause of death: ICD10 E11.3 Non-insulin-dependent diabetes mellitus - With ophthalmic complications
40001 Underlying (primary) cause of death: ICD10 E12.3 Malnutrition-related diabetes mellitus - With ophthalmic complications
40001 Underlying (primary) cause of death: ICD10 E13.3 Other specified diabetes mellitus - With ophthalmic complications
40001 Underlying (primary) cause of death: ICD10 E14.3 Unspecified diabetes mellitus - With ophthalmic complications
40001 Underlying (primary) cause of death: ICD10 H28.0 Diabetic cataract
40001 Underlying (primary) cause of death: ICD10 H36.0 Diabetic retinopathy
40002 Contributory (secondary) causes of death: ICD10 H35.0 Background retinopathy and retinal vascular changes
40002 Contributory (secondary) causes of death: ICD10 H35.2 Other proliferative retinopathy
40002 Contributory (secondary) causes of death: ICD10 E10.3 Insulin-dependent diabetes mellitus - With ophthalmic complications
40002 Contributory (secondary) causes of death: ICD10 E11.3 Non-insulin-dependent diabetes mellitus - With ophthalmic complications
40002 Contributory (secondary) causes of death: ICD10 E12.3 Malnutrition-related diabetes mellitus - With ophthalmic complications
40002 Contributory (secondary) causes of death: ICD10 E13.3 Other specified diabetes mellitus - With ophthalmic complications
40002 Contributory (secondary) causes of death: ICD10 E14.3 Unspecified diabetes mellitus - With ophthalmic complications
40002 Contributory (secondary) causes of death: ICD10 H28.0 Diabetic cataract
40002 Contributory (secondary) causes of death: ICD10 H36.0 Diabetic retinopathy
42040 GP clinical event records 2BBk.00 O/E - right eye stable treated prolif diabetic retinopathy
42040 GP clinical event records 2BBl.00 O/E - left eye stable treated prolif diabetic retinopathy
42040 GP clinical event records 2BBL.00 O/E - diabetic maculopathy present both eyes
42040 GP clinical event records 2BBM.00 O/E - diabetic maculopathy absent both eyes
42040 GP clinical event records 2BBo.00 O/E - sight threatening diabetic retinopathy
42040 GP clinical event records 2BBP.00 O/E - right eye background diabetic retinopathy
42040 GP clinical event records 2BBQ.00 O/E - left eye background diabetic retinopathy
42040 GP clinical event records 2BBr.00 Impaired vision due to diabetic retinopathy
42040 GP clinical event records 2BBR.00 O/E - right eye preproliferative diabetic retinopathy
42040 GP clinical event records 2BBS.00 O/E - left eye preproliferative diabetic retinopathy
42040 GP clinical event records 2BBT.00 O/E - right eye proliferative diabetic retinopathy
42040 GP clinical event records 2BBV.00 O/E - left eye proliferative diabetic retinopathy
42040 GP clinical event records 2BBW.00 O/E - right eye diabetic maculopathy
42040 GP clinical event records 2BBX.00 O/E - left eye diabetic maculopathy
42040 GP clinical event records 7276.00 Pan retinal photocoagulation for diabetes
42040 GP clinical event records C105000 Diabetes mellitus, juvenile type, + ophthalmic manifestation
42040 GP clinical event records C105100 Diabetes mellitus, adult onset, + ophthalmic manifestation
42040 GP clinical event records C105.00 Diabetes mellitus with ophthalmic manifestation
42040 GP clinical event records C105y00 Other specified diabetes mellitus with ophthalmic complicatn
42040 GP clinical event records C105z00 Diabetes mellitus NOS with ophthalmic manifestation
42040 GP clinical event records C108100 Insulin-dependent diabetes mellitus with ophthalmic comps
42040 GP clinical event records C108112 Type 1 diabetes mellitus with ophthalmic complications
42040 GP clinical event records C108700 Insulin dependent diabetes mellitus with retinopathy
42040 GP clinical event records C108711 Type I diabetes mellitus with retinopathy
42040 GP clinical event records C108712 Type 1 diabetes mellitus with retinopathy
42040 GP clinical event records C108F00 Insulin dependent diabetes mellitus with diabetic cataract
42040 GP clinical event records C108F11 Type I diabetes mellitus with diabetic cataract
42040 GP clinical event records C108F12 Type 1 diabetes mellitus with diabetic cataract
42040 GP clinical event records C109100 Non-insulin-dependent diabetes mellitus with ophthalm comps
42040 GP clinical event records C109111 Type II diabetes mellitus with ophthalmic complications
42040 GP clinical event records C109112 Type 2 diabetes mellitus with ophthalmic complications
42040 GP clinical event records C109600 Non-insulin-dependent diabetes mellitus with retinopathy
42040 GP clinical event records C109611 Type II diabetes mellitus with retinopathy
42040 GP clinical event records C109612 Type 2 diabetes mellitus with retinopathy
42040 GP clinical event records C109E00 Non-insulin depend diabetes mellitus with diabetic cataract
42040 GP clinical event records C109E11 Type II diabetes mellitus with diabetic cataract
42040 GP clinical event records C109E12 Type 2 diabetes mellitus with diabetic cataract
42040 GP clinical event records C10E100 Type 1 diabetes mellitus with ophthalmic complications
42040 GP clinical event records C10E111 Type I diabetes mellitus with ophthalmic complications
42040 GP clinical event records C10E112 Insulin-dependent diabetes mellitus with ophthalmic comps
42040 GP clinical event records C10E700 Type 1 diabetes mellitus with retinopathy
42040 GP clinical event records C10E711 Type I diabetes mellitus with retinopathy
42040 GP clinical event records C10E712 Insulin dependent diabetes mellitus with retinopathy
42040 GP clinical event records C10EF00 Type 1 diabetes mellitus with diabetic cataract
42040 GP clinical event records C10EF12 Insulin dependent diabetes mellitus with diabetic cataract
42040 GP clinical event records C10EP00 Type 1 diabetes mellitus with exudative maculopathy
42040 GP clinical event records C10EP11 Type I diabetes mellitus with exudative maculopathy
42040 GP clinical event records C10F100 Type 2 diabetes mellitus with ophthalmic complications
42040 GP clinical event records C10F111 Type II diabetes mellitus with ophthalmic complications
42040 GP clinical event records C10F600 Type 2 diabetes mellitus with retinopathy
42040 GP clinical event records C10F611 Type II diabetes mellitus with retinopathy
42040 GP clinical event records C10FE00 Type 2 diabetes mellitus with diabetic cataract
42040 GP clinical event records C10FE11 Type II diabetes mellitus with diabetic cataract
42040 GP clinical event records C10FQ00 Type 2 diabetes mellitus with exudative maculopathy
42040 GP clinical event records F420000 Background diabetic retinopathy
42040 GP clinical event records F420100 Proliferative diabetic retinopathy
42040 GP clinical event records F420200 Preproliferative diabetic retinopathy
42040 GP clinical event records F420300 Advanced diabetic maculopathy
42040 GP clinical event records F420400 Diabetic maculopathy
42040 GP clinical event records F420500 Advanced diabetic retinal disease
42040 GP clinical event records F420600 Non proliferative diabetic retinopathy
42040 GP clinical event records F420700 High risk proliferative diabetic retinopathy
42040 GP clinical event records F420800 High risk non proliferative diabetic retinopathy
42040 GP clinical event records F420.00 Diabetic retinopathy
42040 GP clinical event records F420z00 Diabetic retinopathy NOS
42040 GP clinical event records F440700 Diabetic iritis
42040 GP clinical event records F464000 Diabetic cataract
42040 GP clinical event records XaJOg O/E - right eye background diabetic retinopathy
42040 GP clinical event records XaJOk O/E - right eye proliferative diabetic retinopathy
42040 GP clinical event records XaKDG O/E - right eye stable treated proliferative diabetic retinopathy
42040 GP clinical event records XaD2T Advanced diabetic retinal disease
42040 GP clinical event records XaJOi O/E - right eye preproliferative diabetic retinopathy
42040 GP clinical event records XaIPk O/E - diabetic maculopathy present both eyes
42040 GP clinical event records XaKcS O/E - sight threatening diabetic retinopathy
42040 GP clinical event records XaJOj O/E - left eye preproliferative diabetic retinopathy
42040 GP clinical event records XaPen Impaired vision due to diabetic retinopathy
42040 GP clinical event records XaKDH O/E - left eye stable treated proliferative diabetic retinopathy
42040 GP clinical event records XaIW8 High risk non proliferative diabetic retinopathy
42040 GP clinical event records XaJOn O/E - right eye diabetic maculopathy
42040 GP clinical event records XaJOo O/E - left eye diabetic maculopathy
42040 GP clinical event records XaIP5 Non proliferative diabetic retinopathy
42040 GP clinical event records XaJOl O/E - left eye proliferative diabetic retinopathy
42040 GP clinical event records XaJOh O/E - left eye background diabetic retinopathy
42040 GP clinical event records XaJSr Type 1 diabetes mellitus with exudative maculopathy
42040 GP clinical event records XaIPl O/E - diabetic maculopathy absent both eyes
42040 GP clinical event records X00dG Diabetic maculopathy
5890 Which eye(s) affected by diabetes-related eye disease 1 Right eye
5890 Which eye(s) affected by diabetes-related eye disease 2 Left eye
5890 Which eye(s) affected by diabetes-related eye disease 3 Both eyes
6148 Eye problems/disorders 1 Diabetes related eye disease