Diabetes NOS

Metadata

Name	Diabetes NOS (diabetes_nos)
Category	Endocrine
Sex
Adult	Yes
UUID	9969743d-7aa2-4f0a-8c87-e278644210b4

Ontologies

GWAS Catalogue

EFO_0000400

Key Summary Statistics

Cases from any source

Total	26977
Female (%)	10226 (38%)
Male (%)	16751 (62%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	281.14 (270.01,292.26)
Male	586.01 (568.79,603.24)

Incidence stratified by sex

Female	4.54 (3.98,5.1)
Male	9.04 (8.16,9.92)

Incidence stratified by age

Ages 40-44	2.96 (1.88,4.04)
Ages 45-49	5.16 (3.93,6.38)
Ages 50-54	6.22 (4.97,7.47)
Ages 55-59	5.74 (4.65,6.83)
Ages 60-64	8.1 (6.98,9.22)
Ages 65-69	8.46 (7.14,9.78)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	40 (34,46)	77 (71,85)	121 (114,128)
CALIBER	30 (28,31)	43 (41,45)	61 (58,63)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	19(10,33)	34(25,46)	82(69,96)
Low	27(16,43)	50(38,65)	86(73,100)
Medium	35(22,51)	58(46,73)	110(96,127)
High	37(25,52)	84(69,102)	131(114,149)
Most deprived	68(53,86)	155(134,178)	215(192,239)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	43(36,51)	79(71,87)	125(117,134)
Scotland	23(11,41)	66(50,86)	93(75,114)
Wales	28(12,54)	81(58,111)	118(93,146)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153646, Events=402

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.07 (0.82, 1.39)	0.637
BMI	obese	2.13 (1.65, 2.77)	1.06e-08
BMI	underweight	0 (0, Inf)	0.986
smoking	previous	1.48 (1.19, 1.85)	0.000498
smoking	current	2.47 (1.87, 3.26)	1.43e-10
hypertension	yes	2.21 (1.8, 2.72)	5.76e-14

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1276	diabetic eye disease
20002	Non-cancer illness code, self-reported	1468	diabetic neuropathy/ulcers
20002	Non-cancer illness code, self-reported	1607	diabetic nephropathy
20002	Non-cancer illness code, self-reported	1220	diabetes
41202	Diagnoses - main ICD10	E12	Malnutrition-related diabetes mellitus
41202	Diagnoses - main ICD10	O24.2	Diabetes mellitus in pregnancy: Pre-existing malnutrition-related diabetes mellitus
41202	Diagnoses - main ICD10	E13	Other specified diabetes mellitus
41202	Diagnoses - main ICD10	E14	Unspecified diabetes mellitus
41202	Diagnoses - main ICD10	G59.0	Diabetic mononeuropathy
41202	Diagnoses - main ICD10	G63.2	Diabetic polyneuropathy
41202	Diagnoses - main ICD10	H28.0	Diabetic cataract
41202	Diagnoses - main ICD10	H36.0	Diabetic retinopathy
41202	Diagnoses - main ICD10	M14.2	Diabetic arthropathy
41202	Diagnoses - main ICD10	N08.3	Glomerular disorders in diabetes mellitus
41202	Diagnoses - main ICD10	O24.3	Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, unspecified
41204	Diagnoses - secondary ICD10	E12	Malnutrition-related diabetes mellitus
41204	Diagnoses - secondary ICD10	O24.2	Diabetes mellitus in pregnancy: Pre-existing malnutrition-related diabetes mellitus
41204	Diagnoses - secondary ICD10	E13	Other specified diabetes mellitus
41204	Diagnoses - secondary ICD10	E14	Unspecified diabetes mellitus
41204	Diagnoses - secondary ICD10	G59.0	Diabetic mononeuropathy
41204	Diagnoses - secondary ICD10	G63.2	Diabetic polyneuropathy
41204	Diagnoses - secondary ICD10	H28.0	Diabetic cataract
41204	Diagnoses - secondary ICD10	H36.0	Diabetic retinopathy
41204	Diagnoses - secondary ICD10	M14.2	Diabetic arthropathy
41204	Diagnoses - secondary ICD10	N08.3	Glomerular disorders in diabetes mellitus
41204	Diagnoses - secondary ICD10	O24.3	Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, unspecified
40001	Underlying (primary) cause of death: ICD10	E12	Malnutrition-related diabetes mellitus
40001	Underlying (primary) cause of death: ICD10	O24.2	Diabetes mellitus in pregnancy: Pre-existing malnutrition-related diabetes mellitus
40001	Underlying (primary) cause of death: ICD10	E13	Other specified diabetes mellitus
40001	Underlying (primary) cause of death: ICD10	E14	Unspecified diabetes mellitus
40001	Underlying (primary) cause of death: ICD10	G59.0	Diabetic mononeuropathy
40001	Underlying (primary) cause of death: ICD10	G63.2	Diabetic polyneuropathy
40001	Underlying (primary) cause of death: ICD10	H28.0	Diabetic cataract
40001	Underlying (primary) cause of death: ICD10	H36.0	Diabetic retinopathy
40001	Underlying (primary) cause of death: ICD10	M14.2	Diabetic arthropathy
40001	Underlying (primary) cause of death: ICD10	N08.3	Glomerular disorders in diabetes mellitus
40001	Underlying (primary) cause of death: ICD10	O24.3	Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, unspecified
40002	Contributory (secondary) causes of death: ICD10	E12	Malnutrition-related diabetes mellitus
40002	Contributory (secondary) causes of death: ICD10	O24.2	Diabetes mellitus in pregnancy: Pre-existing malnutrition-related diabetes mellitus
40002	Contributory (secondary) causes of death: ICD10	E13	Other specified diabetes mellitus
40002	Contributory (secondary) causes of death: ICD10	E14	Unspecified diabetes mellitus
40002	Contributory (secondary) causes of death: ICD10	G59.0	Diabetic mononeuropathy
40002	Contributory (secondary) causes of death: ICD10	G63.2	Diabetic polyneuropathy
40002	Contributory (secondary) causes of death: ICD10	H28.0	Diabetic cataract
40002	Contributory (secondary) causes of death: ICD10	H36.0	Diabetic retinopathy
40002	Contributory (secondary) causes of death: ICD10	M14.2	Diabetic arthropathy
40002	Contributory (secondary) causes of death: ICD10	N08.3	Glomerular disorders in diabetes mellitus
40002	Contributory (secondary) causes of death: ICD10	O24.3	Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, unspecified