Diabetes Type I

Metadata

Name	Diabetes Type I (diabetes_t1)
Category	Endocrine
Sex
Adult	Yes
UUID	9969743d-7aa2-4f0a-8c87-e278644210b4

Ontologies

GWAS Catalogue

MONDO_0005147

Key Summary Statistics

Cases from any source

Total	5121
Female (%)	2190 (43%)
Male (%)	2931 (57%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	41.49 (37.17,45.82)
Male	61.88 (56.13,67.63)

Incidence stratified by sex

Female	2.82 (2.39,3.26)
Male	5.53 (4.86,6.2)

Incidence stratified by age

Ages 40-44	3.03 (1.95,4.11)
Ages 45-49	2.83 (1.93,3.73)
Ages 50-54	2.67 (1.86,3.48)
Ages 55-59	3.81 (2.94,4.69)
Ages 60-64	4.64 (3.81,5.47)
Ages 65-69	5.96 (4.89,7.04)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	61 (53,69)	74 (67,81)	98 (91,104)
CALIBER	55 (53,57)	49 (47,51)	38 (36,40)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	45(31,63)	43(33,56)	73(61,86)
Low	44(30,63)	56(44,71)	81(68,94)
Medium	55(40,75)	60(47,75)	85(72,99)
High	61(46,79)	83(68,100)	96(82,113)
Most deprived	87(70,107)	122(104,143)	166(146,187)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	62(54,71)	71(64,79)	99(92,106)
Scotland	55(36,81)	81(63,102)	92(75,113)
Wales	52(30,85)	85(61,115)	94(72,120)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153646, Events=402

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.07 (0.82, 1.39)	0.637
BMI	obese	2.13 (1.65, 2.77)	1.06e-08
BMI	underweight	0 (0, Inf)	0.986
smoking	previous	1.48 (1.19, 1.85)	0.000498
smoking	current	2.47 (1.87, 3.26)	1.43e-10
hypertension	yes	2.21 (1.8, 2.72)	5.76e-14

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1222	type 1 diabetes
41202	Diagnoses - main ICD10	E10	Insulin-dependent diabetes mellitus
41202	Diagnoses - main ICD10	O24.0	Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
41204	Diagnoses - secondary ICD10	E10	Insulin-dependent diabetes mellitus
41204	Diagnoses - secondary ICD10	O24.0	Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
40001	Underlying (primary) cause of death: ICD10	E10	Insulin-dependent diabetes mellitus
40001	Underlying (primary) cause of death: ICD10	O24.0	Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
40002	Contributory (secondary) causes of death: ICD10	E10	Insulin-dependent diabetes mellitus
40002	Contributory (secondary) causes of death: ICD10	O24.0	Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
42040	GP clinical event records	C108.12	Type 1 diabetes mellitus
42040	GP clinical event records	C108.13	Type I diabetes mellitus
42040	GP clinical event records	C108011	Type I diabetes mellitus with renal complications
42040	GP clinical event records	C108012	Type 1 diabetes mellitus with renal complications
42040	GP clinical event records	C108211	Type I diabetes mellitus with neurological complications
42040	GP clinical event records	C108212	Type 1 diabetes mellitus with neurological complications
42040	GP clinical event records	C108411	Unstable type I diabetes mellitus
42040	GP clinical event records	C108412	Unstable type 1 diabetes mellitus
42040	GP clinical event records	C108511	Type I diabetes mellitus with ulcer
42040	GP clinical event records	C108512	Type 1 diabetes mellitus with ulcer
42040	GP clinical event records	C108711	Type I diabetes mellitus with retinopathy
42040	GP clinical event records	C108712	Type 1 diabetes mellitus with retinopathy
42040	GP clinical event records	C108811	Type I diabetes mellitus - poor control
42040	GP clinical event records	C108812	Type 1 diabetes mellitus - poor control
42040	GP clinical event records	C108911	Type I diabetes mellitus maturity onset
42040	GP clinical event records	C108912	Type 1 diabetes mellitus maturity onset
42040	GP clinical event records	C108A11	Type I diabetes mellitus without complication
42040	GP clinical event records	C108D11	Type I diabetes mellitus with nephropathy
42040	GP clinical event records	C108E11	Type I diabetes mellitus with hypoglycaemic coma
42040	GP clinical event records	C108E12	Type 1 diabetes mellitus with hypoglycaemic coma
42040	GP clinical event records	C108F11	Type I diabetes mellitus with diabetic cataract
42040	GP clinical event records	C108H11	Type I diabetes mellitus with arthropathy
42040	GP clinical event records	C108J11	Type I diabetes mellitus with neuropathic arthropathy
42040	GP clinical event records	C108J12	Type 1 diabetes mellitus with neuropathic arthropathy
42040	GP clinical event records	C10E.00	Type 1 diabetes mellitus
42040	GP clinical event records	C10E.11	Type I diabetes mellitus
42040	GP clinical event records	C10E000	Type 1 diabetes mellitus with renal complications
42040	GP clinical event records	C10E100	Type 1 diabetes mellitus with ophthalmic complications
42040	GP clinical event records	C10E200	Type 1 diabetes mellitus with neurological complications
42040	GP clinical event records	C10E300	Type 1 diabetes mellitus with multiple complications
42040	GP clinical event records	C10E311	Type I diabetes mellitus with multiple complications
42040	GP clinical event records	C10E400	Unstable type 1 diabetes mellitus
42040	GP clinical event records	C10E411	Unstable type I diabetes mellitus
42040	GP clinical event records	C10E500	Type 1 diabetes mellitus with ulcer
42040	GP clinical event records	C10E511	Type I diabetes mellitus with ulcer
42040	GP clinical event records	C10E600	Type 1 diabetes mellitus with gangrene
42040	GP clinical event records	C10E700	Type 1 diabetes mellitus with retinopathy
42040	GP clinical event records	C10E711	Type I diabetes mellitus with retinopathy
42040	GP clinical event records	C10E800	Type 1 diabetes mellitus - poor control
42040	GP clinical event records	C10E900	Type 1 diabetes mellitus maturity onset
42040	GP clinical event records	C10E911	Type I diabetes mellitus maturity onset
42040	GP clinical event records	C10EA00	Type 1 diabetes mellitus without complication
42040	GP clinical event records	C10EA11	Type I diabetes mellitus without complication
42040	GP clinical event records	C10EB00	Type 1 diabetes mellitus with mononeuropathy
42040	GP clinical event records	C10EC00	Type 1 diabetes mellitus with polyneuropathy
42040	GP clinical event records	C10EC11	Type I diabetes mellitus with polyneuropathy
42040	GP clinical event records	C10ED00	Type 1 diabetes mellitus with nephropathy
42040	GP clinical event records	C10EE00	Type 1 diabetes mellitus with hypoglycaemic coma
42040	GP clinical event records	C10EF00	Type 1 diabetes mellitus with diabetic cataract
42040	GP clinical event records	C10EG00	Type 1 diabetes mellitus with peripheral angiopathy
42040	GP clinical event records	C10EH00	Type 1 diabetes mellitus with arthropathy
42040	GP clinical event records	C10EJ00	Type 1 diabetes mellitus with neuropathic arthropathy
42040	GP clinical event records	C10EK00	Type 1 diabetes mellitus with persistent proteinuria
42040	GP clinical event records	C10EL00	Type 1 diabetes mellitus with persistent microalbuminuria
42040	GP clinical event records	C10EM00	Type 1 diabetes mellitus with ketoacidosis
42040	GP clinical event records	C10EM11	Type I diabetes mellitus with ketoacidosis
42040	GP clinical event records	C10EN00	Type 1 diabetes mellitus with ketoacidotic coma
42040	GP clinical event records	C10EN11	Type I diabetes mellitus with ketoacidotic coma
42040	GP clinical event records	C10EP00	Type 1 diabetes mellitus with exudative maculopathy
42040	GP clinical event records	C10EP11	Type I diabetes mellitus with exudative maculopathy
42040	GP clinical event records	C10EQ00	Type 1 diabetes mellitus with gastroparesis
42040	GP clinical event records	XaIzN	Type 1 diabetes mellitus with persistent microalbuminuria
42040	GP clinical event records	C1030	Type 1 diabetes mellitus with ketoacidotic coma
42040	GP clinical event records	XaIzM	Type 1 diabetes mellitus with persistent proteinuria
42040	GP clinical event records	XaKyW	Type 1 diabetes mellitus with gastroparesis
42040	GP clinical event records	XaJSr	Type 1 diabetes mellitus with exudative maculopathy
42040	GP clinical event records	C1010	Type 1 diabetes mellitus with ketoacidosis
42040	GP clinical event records	C1010	Type 1 diabetes mellitus with ketoacidosis