Diabetes Type II

Metadata

Name	Diabetes Type II (diabetes_t2)
Category	Endocrine
Sex
Adult	Yes
UUID	9969743d-7aa2-4f0a-8c87-e278644210b4

Ontologies

GWAS Catalogue

MONDO_0005148

Key Summary Statistics

Cases from any source

Total	42662
Female (%)	17251 (40%)
Male (%)	25411 (60%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	187.54 (178.41,196.67)
Male	391.7 (377.47,405.93)

Incidence stratified by sex

Female	36.37 (34.78,37.96)
Male	66.54 (64.15,68.93)

Incidence stratified by age

Ages 40-44	20.49 (17.66,23.32)
Ages 45-49	30.22 (27.25,33.18)
Ages 50-54	37.21 (34.15,40.26)
Ages 55-59	49.67 (46.46,52.89)
Ages 60-64	59.97 (56.92,63.03)
Ages 65-69	76.63 (72.65,80.62)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	252 (237,268)	486 (469,504)	789 (771,808)
CALIBER	382 (376,387)	820 (811,828)	1323 (1311,

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	121(96,150)	302(272,334)	561(528,596)
Low	155(127,188)	340(307,374)	657(621,694)
Medium	194(164,229)	440(403,478)	693(656,733)
High	270(236,306)	506(467,546)	867(823,913)
Most deprived	437(397,479)	824(776,874)	1261(1206,1318)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	241(224,258)	436(418,455)	737(717,757)
Scotland	261(217,312)	603(552,657)	905(848,965)
Wales	370(304,447)	784(708,865)	1166(1086,1250)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153646, Events=402

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.07 (0.82, 1.39)	0.637
BMI	obese	2.13 (1.65, 2.77)	1.06e-08
BMI	underweight	0 (0, Inf)	0.986
smoking	previous	1.48 (1.19, 1.85)	0.000498
smoking	current	2.47 (1.87, 3.26)	1.43e-10
hypertension	yes	2.21 (1.8, 2.72)	5.76e-14

Genetic correlation

Genetic correlation (rg)	P value
0.97	5.15e-231

Published study: Scott (2017)

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1223	type 2 diabetes
41202	Diagnoses - main ICD10	E11	Non-insulin-dependent diabetes mellitus
41202	Diagnoses - main ICD10	O24.0	Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
41204	Diagnoses - secondary ICD10	E11	Non-insulin-dependent diabetes mellitus
41204	Diagnoses - secondary ICD10	O24.0	Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
40001	Underlying (primary) cause of death: ICD10	E11	Non-insulin-dependent diabetes mellitus
40001	Underlying (primary) cause of death: ICD10	O24.0	Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
40002	Contributory (secondary) causes of death: ICD10	E11	Non-insulin-dependent diabetes mellitus
40002	Contributory (secondary) causes of death: ICD10	O24.0	Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
42040	GP clinical event records	C109.12	Type 2 diabetes mellitus
42040	GP clinical event records	C109.13	Type II diabetes mellitus
42040	GP clinical event records	C109011	Type II diabetes mellitus with renal complications
42040	GP clinical event records	C109012	Type 2 diabetes mellitus with renal complications
42040	GP clinical event records	C109111	Type II diabetes mellitus with ophthalmic complications
42040	GP clinical event records	C109112	Type 2 diabetes mellitus with ophthalmic complications
42040	GP clinical event records	C109211	Type II diabetes mellitus with neurological complications
42040	GP clinical event records	C109212	Type 2 diabetes mellitus with neurological complications
42040	GP clinical event records	C109411	Type II diabetes mellitus with ulcer
42040	GP clinical event records	C109412	Type 2 diabetes mellitus with ulcer
42040	GP clinical event records	C109511	Type II diabetes mellitus with gangrene
42040	GP clinical event records	C109512	Type 2 diabetes mellitus with gangrene
42040	GP clinical event records	C109611	Type II diabetes mellitus with retinopathy
42040	GP clinical event records	C109612	Type 2 diabetes mellitus with retinopathy
42040	GP clinical event records	C109711	Type II diabetes mellitus - poor control
42040	GP clinical event records	C109712	Type 2 diabetes mellitus - poor control
42040	GP clinical event records	C109A11	Type II diabetes mellitus with mononeuropathy
42040	GP clinical event records	C109B11	Type II diabetes mellitus with polyneuropathy
42040	GP clinical event records	C109C11	Type II diabetes mellitus with nephropathy
42040	GP clinical event records	C109C12	Type 2 diabetes mellitus with nephropathy
42040	GP clinical event records	C109D11	Type II diabetes mellitus with hypoglycaemic coma
42040	GP clinical event records	C109D12	Type 2 diabetes mellitus with hypoglycaemic coma
42040	GP clinical event records	C109E11	Type II diabetes mellitus with diabetic cataract
42040	GP clinical event records	C109E12	Type 2 diabetes mellitus with diabetic cataract
42040	GP clinical event records	C109F11	Type II diabetes mellitus with peripheral angiopathy
42040	GP clinical event records	C109F12	Type 2 diabetes mellitus with peripheral angiopathy
42040	GP clinical event records	C109G11	Type II diabetes mellitus with arthropathy
42040	GP clinical event records	C109G12	Type 2 diabetes mellitus with arthropathy
42040	GP clinical event records	C109H11	Type II diabetes mellitus with neuropathic arthropathy
42040	GP clinical event records	C109H12	Type 2 diabetes mellitus with neuropathic arthropathy
42040	GP clinical event records	C109J00	Insulin treated Type 2 diabetes mellitus
42040	GP clinical event records	C109J12	Insulin treated Type II diabetes mellitus
42040	GP clinical event records	C109K00	Hyperosmolar non-ketotic state in type 2 diabetes mellitus
42040	GP clinical event records	C10F.00	Type 2 diabetes mellitus
42040	GP clinical event records	C10F.11	Type II diabetes mellitus
42040	GP clinical event records	C10F000	Type 2 diabetes mellitus with renal complications
42040	GP clinical event records	C10F011	Type II diabetes mellitus with renal complications
42040	GP clinical event records	C10F100	Type 2 diabetes mellitus with ophthalmic complications
42040	GP clinical event records	C10F200	Type 2 diabetes mellitus with neurological complications
42040	GP clinical event records	C10F211	Type II diabetes mellitus with neurological complications
42040	GP clinical event records	C10F300	Type 2 diabetes mellitus with multiple complications
42040	GP clinical event records	C10F311	Type II diabetes mellitus with multiple complications
42040	GP clinical event records	C10F400	Type 2 diabetes mellitus with ulcer
42040	GP clinical event records	C10F411	Type II diabetes mellitus with ulcer
42040	GP clinical event records	C10F500	Type 2 diabetes mellitus with gangrene
42040	GP clinical event records	C10F600	Type 2 diabetes mellitus with retinopathy
42040	GP clinical event records	C10F611	Type II diabetes mellitus with retinopathy
42040	GP clinical event records	C10F700	Type 2 diabetes mellitus - poor control
42040	GP clinical event records	C10F711	Type II diabetes mellitus - poor control
42040	GP clinical event records	C10F900	Type 2 diabetes mellitus without complication
42040	GP clinical event records	C10F911	Type II diabetes mellitus without complication
42040	GP clinical event records	C10FA00	Type 2 diabetes mellitus with mononeuropathy
42040	GP clinical event records	C10FA11	Type II diabetes mellitus with mononeuropathy
42040	GP clinical event records	C10FB00	Type 2 diabetes mellitus with polyneuropathy
42040	GP clinical event records	C10FB11	Type II diabetes mellitus with polyneuropathy
42040	GP clinical event records	C10FC00	Type 2 diabetes mellitus with nephropathy
42040	GP clinical event records	C10FD00	Type 2 diabetes mellitus with hypoglycaemic coma
42040	GP clinical event records	C10FD11	Type II diabetes mellitus with hypoglycaemic coma
42040	GP clinical event records	C10FE00	Type 2 diabetes mellitus with diabetic cataract
42040	GP clinical event records	C10FE11	Type II diabetes mellitus with diabetic cataract
42040	GP clinical event records	C10FF00	Type 2 diabetes mellitus with peripheral angiopathy
42040	GP clinical event records	C10FG00	Type 2 diabetes mellitus with arthropathy
42040	GP clinical event records	C10FH00	Type 2 diabetes mellitus with neuropathic arthropathy
42040	GP clinical event records	C10FJ00	Insulin treated Type 2 diabetes mellitus
42040	GP clinical event records	C10FJ11	Insulin treated Type II diabetes mellitus
42040	GP clinical event records	C10FK00	Hyperosmolar non-ketotic state in type 2 diabetes mellitus
42040	GP clinical event records	C10FL00	Type 2 diabetes mellitus with persistent proteinuria
42040	GP clinical event records	C10FL11	Type II diabetes mellitus with persistent proteinuria
42040	GP clinical event records	C10FM00	Type 2 diabetes mellitus with persistent microalbuminuria
42040	GP clinical event records	C10FM11	Type II diabetes mellitus with persistent microalbuminuria
42040	GP clinical event records	C10FN00	Type 2 diabetes mellitus with ketoacidosis
42040	GP clinical event records	C10FP00	Type 2 diabetes mellitus with ketoacidotic coma
42040	GP clinical event records	C10FQ00	Type 2 diabetes mellitus with exudative maculopathy
42040	GP clinical event records	C10FR00	Type 2 diabetes mellitus with gastroparesis
42040	GP clinical event records	X40J6	Insulin treated Type 2 diabetes mellitus
42040	GP clinical event records	C1011	Type 2 diabetes mellitus with ketoacidosis
42040	GP clinical event records	X40J6	Insulin treated Type 2 diabetes mellitus