Metadata

Name Infections of the digestive system (digestive)
Category Infections
Sex
Adult Yes
UUID 67d56a2b-dec5-4723-89f5-fc1923078079
Definition Infections of the digestive system

Ontologies

GWAS Catalogue MONDO_0043424
SNOMED-CT 312158001

Key Summary Statistics

Cases from any source

Total 29101
Female (%) 16190 (56%)
Male (%) 12911 (44%)

Year first recorded

digestive year of first event

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Cross-sourced digestive cases

Incidence & prevalence

Sex and age-stratified incidence and prevalence of digestive

Baseline prevalence stratified by sex

Female 87.82 (81.54,94.1)
Male 86.94 (80.13,93.74)

Incidence stratified by sex

Female 32.06 (30.57,33.54)
Male 32.03 (30.41,33.65)

Incidence stratified by age

Ages 40-44 18.79 (16.08,21.49)
Ages 45-49 21.51 (19.02,24.0)
Ages 50-54 28.93 (26.26,31.6)
Ages 55-59 31.82 (29.28,34.35)
Ages 60-64 34.9 (32.61,37.18)
Ages 65-69 44.88 (41.91,47.86)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

CALIBER and UKB digestive prevalence comparison for multiple age groups

Population Ages 40-49 Ages 50-59 Ages 60-69
UK Biobank 176 (163,189) 231 (220,243) 293 (282,304)
CALIBER 134 (131,137) 186 (182,190) 276 (271,281)

Stratified by age and Townsend deprivation status

Deprivation status Ages 40-49 Ages 50-59 Ages 60-69
Least deprived 144(117,174) 172(150,196) 223(203,245)
Low 148(121,179) 201(177,227) 272(249,296)
Medium 136(111,165) 215(191,242) 282(258,307)
High 193(165,223) 243(217,271) 316(290,344)
Most deprived 231(203,262) 321(292,353) 392(361,424)

Stratified by age and country

Country Ages 40-49 Ages 50-59 Ages 60-69
England 194(179,209) 250(236,264) 314(302,327)
Scotland 86(62,116) 134(111,161) 164(141,190)
Wales 131(93,179) 211(174,255) 264(227,306)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153969, Events=129

Factor Level Hazard Ratio P value
BMI overweight 1.18 (0.74, 1.86) 0.489
BMI obese 1.91 (1.2, 3.06) 0.00685
BMI underweight 0 (0, Inf) 0.995
smoking previous 1.29 (0.88, 1.87) 0.189
smoking current 1.41 (0.81, 2.45) 0.23
hypertension yes 1.93 (1.34, 2.77) 0.000403

Risk factors analysis forest plot

Definition

UK Biobank field id Description Code Value
20002 Non-cancer illness code, self-reported 1577 typhoid fever
20002 Non-cancer illness code, self-reported 1675 giardia / giardiasis
20002 Non-cancer illness code, self-reported 1442 helicobacter pylori
41202 Diagnoses - main ICD10 A00 Cholera
41202 Diagnoses - main ICD10 A01 Typhoid and paratyphoid fevers
41202 Diagnoses - main ICD10 A02.0 Salmonella enteritis
41202 Diagnoses - main ICD10 A03 Shigellosis
41202 Diagnoses - main ICD10 A04 Other bacterial intestinal infections
41202 Diagnoses - main ICD10 A05 Other bacterial foodborne intoxications, not elsewhere classified
41202 Diagnoses - main ICD10 A06.0 Acute amoebic dysentery
41202 Diagnoses - main ICD10 A06.1 Chronic intestinal amoebiasis
41202 Diagnoses - main ICD10 A06.2 Amoebic nondysenteric colitis
41202 Diagnoses - main ICD10 A06.3 Amoeboma of intestine
41202 Diagnoses - main ICD10 A07 Other protozoal intestinal diseases
41202 Diagnoses - main ICD10 A08 Viral and other specified intestinal infections
41202 Diagnoses - main ICD10 A09 Other gastroenteritis and colitis of infectious and unspecified origin
41202 Diagnoses - main ICD10 A18.3 Tuberculosis of intestines, peritoneum and mesenteric glands
41202 Diagnoses - main ICD10 A21.3 Gastrointestinal tularaemia
41202 Diagnoses - main ICD10 A22.2 Gastrointestinal anthrax
41202 Diagnoses - main ICD10 B05.4 Measles with intestinal complications
41202 Diagnoses - main ICD10 B46.2 Gastrointestinal mucormycosis
41202 Diagnoses - main ICD10 B78.0 Intestinal strongyloidiasis
41202 Diagnoses - main ICD10 B81 Other intestinal helminthiases, not elsewhere classified
41202 Diagnoses - main ICD10 B82 Unspecified intestinal parasitism
41202 Diagnoses - main ICD10 B98.0 Helicobacter pylori [H.pylori] as the cause of diseases classified to other chapters
41202 Diagnoses - main ICD10 K23.0 Tuberculous oesophagitis
41202 Diagnoses - main ICD10 K23.1 Megaoesophagus in Chagas’ disease
41202 Diagnoses - main ICD10 K63.0 Abscess of intestine
41202 Diagnoses - main ICD10 K93.0 Tuberculous disorders of intestines, peritoneum and mesenteric glands
41204 Diagnoses - secondary ICD10 A00 Cholera
41204 Diagnoses - secondary ICD10 A01 Typhoid and paratyphoid fevers
41204 Diagnoses - secondary ICD10 A02.0 Salmonella enteritis
41204 Diagnoses - secondary ICD10 A03 Shigellosis
41204 Diagnoses - secondary ICD10 A04 Other bacterial intestinal infections
41204 Diagnoses - secondary ICD10 A05 Other bacterial foodborne intoxications, not elsewhere classified
41204 Diagnoses - secondary ICD10 A06.0 Acute amoebic dysentery
41204 Diagnoses - secondary ICD10 A06.1 Chronic intestinal amoebiasis
41204 Diagnoses - secondary ICD10 A06.2 Amoebic nondysenteric colitis
41204 Diagnoses - secondary ICD10 A06.3 Amoeboma of intestine
41204 Diagnoses - secondary ICD10 A07 Other protozoal intestinal diseases
41204 Diagnoses - secondary ICD10 A08 Viral and other specified intestinal infections
41204 Diagnoses - secondary ICD10 A09 Other gastroenteritis and colitis of infectious and unspecified origin
41204 Diagnoses - secondary ICD10 A18.3 Tuberculosis of intestines, peritoneum and mesenteric glands
41204 Diagnoses - secondary ICD10 A21.3 Gastrointestinal tularaemia
41204 Diagnoses - secondary ICD10 A22.2 Gastrointestinal anthrax
41204 Diagnoses - secondary ICD10 B05.4 Measles with intestinal complications
41204 Diagnoses - secondary ICD10 B46.2 Gastrointestinal mucormycosis
41204 Diagnoses - secondary ICD10 B78.0 Intestinal strongyloidiasis
41204 Diagnoses - secondary ICD10 B81 Other intestinal helminthiases, not elsewhere classified
41204 Diagnoses - secondary ICD10 B82 Unspecified intestinal parasitism
41204 Diagnoses - secondary ICD10 B98.0 Helicobacter pylori [H.pylori] as the cause of diseases classified to other chapters
41204 Diagnoses - secondary ICD10 K23.0 Tuberculous oesophagitis
41204 Diagnoses - secondary ICD10 K23.1 Megaoesophagus in Chagas’ disease
41204 Diagnoses - secondary ICD10 K63.0 Abscess of intestine
41204 Diagnoses - secondary ICD10 K93.0 Tuberculous disorders of intestines, peritoneum and mesenteric glands
40001 Underlying (primary) cause of death: ICD10 A00 Cholera
40001 Underlying (primary) cause of death: ICD10 A01 Typhoid and paratyphoid fevers
40001 Underlying (primary) cause of death: ICD10 A02.0 Salmonella enteritis
40001 Underlying (primary) cause of death: ICD10 A03 Shigellosis
40001 Underlying (primary) cause of death: ICD10 A04 Other bacterial intestinal infections
40001 Underlying (primary) cause of death: ICD10 A05 Other bacterial foodborne intoxications, not elsewhere classified
40001 Underlying (primary) cause of death: ICD10 A06.0 Acute amoebic dysentery
40001 Underlying (primary) cause of death: ICD10 A06.1 Chronic intestinal amoebiasis
40001 Underlying (primary) cause of death: ICD10 A06.2 Amoebic nondysenteric colitis
40001 Underlying (primary) cause of death: ICD10 A06.3 Amoeboma of intestine
40001 Underlying (primary) cause of death: ICD10 A07 Other protozoal intestinal diseases
40001 Underlying (primary) cause of death: ICD10 A08 Viral and other specified intestinal infections
40001 Underlying (primary) cause of death: ICD10 A09 Other gastroenteritis and colitis of infectious and unspecified origin
40001 Underlying (primary) cause of death: ICD10 A18.3 Tuberculosis of intestines, peritoneum and mesenteric glands
40001 Underlying (primary) cause of death: ICD10 A21.3 Gastrointestinal tularaemia
40001 Underlying (primary) cause of death: ICD10 A22.2 Gastrointestinal anthrax
40001 Underlying (primary) cause of death: ICD10 B05.4 Measles with intestinal complications
40001 Underlying (primary) cause of death: ICD10 B46.2 Gastrointestinal mucormycosis
40001 Underlying (primary) cause of death: ICD10 B78.0 Intestinal strongyloidiasis
40001 Underlying (primary) cause of death: ICD10 B81 Other intestinal helminthiases, not elsewhere classified
40001 Underlying (primary) cause of death: ICD10 B82 Unspecified intestinal parasitism
40001 Underlying (primary) cause of death: ICD10 B98.0 Helicobacter pylori [H.pylori] as the cause of diseases classified to other chapters
40001 Underlying (primary) cause of death: ICD10 K23.0 Tuberculous oesophagitis
40001 Underlying (primary) cause of death: ICD10 K23.1 Megaoesophagus in Chagas’ disease
40001 Underlying (primary) cause of death: ICD10 K63.0 Abscess of intestine
40001 Underlying (primary) cause of death: ICD10 K93.0 Tuberculous disorders of intestines, peritoneum and mesenteric glands
40002 Contributory (secondary) causes of death: ICD10 A00 Cholera
40002 Contributory (secondary) causes of death: ICD10 A01 Typhoid and paratyphoid fevers
40002 Contributory (secondary) causes of death: ICD10 A02.0 Salmonella enteritis
40002 Contributory (secondary) causes of death: ICD10 A03 Shigellosis
40002 Contributory (secondary) causes of death: ICD10 A04 Other bacterial intestinal infections
40002 Contributory (secondary) causes of death: ICD10 A05 Other bacterial foodborne intoxications, not elsewhere classified
40002 Contributory (secondary) causes of death: ICD10 A06.0 Acute amoebic dysentery
40002 Contributory (secondary) causes of death: ICD10 A06.1 Chronic intestinal amoebiasis
40002 Contributory (secondary) causes of death: ICD10 A06.2 Amoebic nondysenteric colitis
40002 Contributory (secondary) causes of death: ICD10 A06.3 Amoeboma of intestine
40002 Contributory (secondary) causes of death: ICD10 A07 Other protozoal intestinal diseases
40002 Contributory (secondary) causes of death: ICD10 A08 Viral and other specified intestinal infections
40002 Contributory (secondary) causes of death: ICD10 A09 Other gastroenteritis and colitis of infectious and unspecified origin
40002 Contributory (secondary) causes of death: ICD10 A18.3 Tuberculosis of intestines, peritoneum and mesenteric glands
40002 Contributory (secondary) causes of death: ICD10 A21.3 Gastrointestinal tularaemia
40002 Contributory (secondary) causes of death: ICD10 A22.2 Gastrointestinal anthrax
40002 Contributory (secondary) causes of death: ICD10 B05.4 Measles with intestinal complications
40002 Contributory (secondary) causes of death: ICD10 B46.2 Gastrointestinal mucormycosis
40002 Contributory (secondary) causes of death: ICD10 B78.0 Intestinal strongyloidiasis
40002 Contributory (secondary) causes of death: ICD10 B81 Other intestinal helminthiases, not elsewhere classified
40002 Contributory (secondary) causes of death: ICD10 B82 Unspecified intestinal parasitism
40002 Contributory (secondary) causes of death: ICD10 B98.0 Helicobacter pylori [H.pylori] as the cause of diseases classified to other chapters
40002 Contributory (secondary) causes of death: ICD10 K23.0 Tuberculous oesophagitis
40002 Contributory (secondary) causes of death: ICD10 K23.1 Megaoesophagus in Chagas’ disease
40002 Contributory (secondary) causes of death: ICD10 K63.0 Abscess of intestine
40002 Contributory (secondary) causes of death: ICD10 K93.0 Tuberculous disorders of intestines, peritoneum and mesenteric glands