Diverticular disease of intestine (acute and chronic)

Metadata

Name	Diverticular disease of intestine (acute and chronic) (diverticuli)
Category	Digestive
Sex
Adult	Yes
UUID	0c23587d-1421-4183-a54c-22adc26bd8d7
Definition	An intestinal disease characterized by the formation and inflammation of diverticula within the bowel wall.

Ontologies

Disease Ontology (DOID)	DOID_7475
GWAS Catalogue	EFO_0009959
MeSH	D000076385
SNOMED-CT	397881000
FinnGen	K11_DIVERTIC

Key Summary Statistics

Cases from any source

Total	65365
Female (%)	35177 (54%)
Male (%)	30188 (46%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	363.06 (350.47,375.65)
Male	338.36 (325.1,351.62)

Incidence stratified by sex

Female	76.07 (73.73,78.4)
Male	82.2 (79.55,84.86)

Incidence stratified by age

Ages 40-44	18.45 (15.77,21.13)
Ages 45-49	35.93 (32.7,39.16)
Ages 50-54	54.78 (51.07,58.49)
Ages 55-59	77.58 (73.53,81.63)
Ages 60-64	101.67 (97.63,105.7)
Ages 65-69	135.48 (130.07,140.89)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	200 (187,214)	566 (548,585)	1127 (1105,1149)
CALIBER	149 (146,152)	450 (444,457)	992 (982,

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	174(145,207)	546(506,588)	1014(970,1060)
Low	177(148,211)	562(521,605)	1079(1033,1126)
Medium	209(177,244)	533(493,574)	1075(1028,1123)
High	199(171,231)	583(543,626)	1180(1129,1233)
Most deprived	231(203,262)	609(568,652)	1326(1270,1384)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	198(183,213)	550(530,570)	1090(1066,1115)
Scotland	235(194,282)	680(627,737)	1317(1250,1388)
Wales	172(128,227)	538(477,605)	1214(1133,1299)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153646, Events=402

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.07 (0.82, 1.39)	0.637
BMI	obese	2.13 (1.65, 2.77)	1.06e-08
BMI	underweight	0 (0, Inf)	0.986
smoking	previous	1.48 (1.19, 1.85)	0.000498
smoking	current	2.47 (1.87, 3.26)	1.43e-10
hypertension	yes	2.21 (1.8, 2.72)	5.76e-14

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1458	diverticular disease/diverticulitis
41202	Diagnoses - main ICD10	K38.2	Diverticulum of appendix
41202	Diagnoses - main ICD10	K57	Diverticular disease of intestine
41204	Diagnoses - secondary ICD10	K38.2	Diverticulum of appendix
41204	Diagnoses - secondary ICD10	K57	Diverticular disease of intestine
41200	Operative procedures - main OPCS4	H12.1	Excision of diverticulum of colon
41210	Operative procedures - secondary OPCS4	H12.1	H12.1
40001	Underlying (primary) cause of death: ICD10	K38.2	Diverticulum of appendix
40001	Underlying (primary) cause of death: ICD10	K57	Diverticular disease of intestine
40002	Contributory (secondary) causes of death: ICD10	K38.2	Diverticulum of appendix
40002	Contributory (secondary) causes of death: ICD10	K57	Diverticular disease of intestine
42040	GP clinical event records	7718000.0	Excision of diverticulum of colon
42040	GP clinical event records	J23z300	Appendicular diverticulum
42040	GP clinical event records	J510000	Diverticulosis of the duodenum
42040	GP clinical event records	J510100	Diverticulosis of the jejunum
42040	GP clinical event records	J510200	Diverticulosis of the ileum
42040	GP clinical event records	J510300	Diverticulosis of the small intestine unspecified
42040	GP clinical event records	J510400	Diverticulosis of the small intestine NOS
42040	GP clinical event records	J510500	Diverticulosis of the colon
42040	GP clinical event records	J510600	Diverticulosis of the large intestine unspecified
42040	GP clinical event records	J510700	Diverticulosis of the large intestine NOS
42040	GP clinical event records	J510800	Divertic dis/both sml+lge intestin without perfor or abscess
42040	GP clinical event records	J510900	Bleeding diverticulosis
42040	GP clinical event records	J510.00	Diverticulosis
42040	GP clinical event records	J510y00	Diverticulosis unspecified
42040	GP clinical event records	J510z00	Diverticulosis NOS
42040	GP clinical event records	J511000	Diverticulitis of the duodenum
42040	GP clinical event records	J511100	Diverticulitis of the jejunum
42040	GP clinical event records	J511200	Diverticulitis of the ileum
42040	GP clinical event records	J511300	Diverticulitis of the small intestine unspecified
42040	GP clinical event records	J511400	Diverticulitis of the small intestine NOS
42040	GP clinical event records	J511500	Diverticulitis of the colon
42040	GP clinical event records	J511600	Diverticulitis of the large intestine unspecified
42040	GP clinical event records	J511700	Diverticulitis of the large intestine NOS
42040	GP clinical event records	J511.00	Diverticulitis
42040	GP clinical event records	J511y00	Diverticulitis unspecified
42040	GP clinical event records	J511z00	Diverticulitis NOS
42040	GP clinical event records	J512000	Perforated diverticulum of duodenum
42040	GP clinical event records	J512100	Perforated diverticulum of jejunum
42040	GP clinical event records	J512200	Perforated diverticulum of ileum
42040	GP clinical event records	J512300	Perforated diverticulum of small intestine unspecified
42040	GP clinical event records	J512400	Perforated diverticulum of small intestine NOS
42040	GP clinical event records	J512500	Perforated diverticulum of colon
42040	GP clinical event records	J512600	Perforated diverticulum of large intestine unspecified
42040	GP clinical event records	J512700	Perforated diverticulum of large intestine NOS
42040	GP clinical event records	J512800	Divertic disease/both sml+lge intestin with perforat+abscess
42040	GP clinical event records	J512.00	Perforated diverticulum
42040	GP clinical event records	J512y00	Perforated diverticulum unspecified
42040	GP clinical event records	J512z00	Perforated diverticulum of intestine NOS
42040	GP clinical event records	J513.00	Diverticular abscess
42040	GP clinical event records	J51..00	Diverticula of intestine
42040	GP clinical event records	J51..11	Diverticular disease
42040	GP clinical event records	J51z.00	Diverticula of the intestine NOS
42040	GP clinical event records	XaB8Z	Diverticulitis