Diabetic neurological complications

Metadata

Name	Diabetic neurological complications (dm_neuro)
Category	Neurological
Sex
Adult	Yes
UUID	440bc327-4f70-425f-bad3-28071056391b
Definition	A chronic, pathological complication associated with diabetes mellitus, where nerve damages are incurred due to diabetic microvascular injury involving small blood vessels that supply these nerves, resulting in peripheral and/or autonomic nerve dysfunction.

Ontologies

Disease Ontology (DOID)	DOID_9743
GWAS Catalogue	EFO_1000783
MeSH	D003929
SNOMED-CT	230572002
FinnGen	DM_NEUROPATHY

Key Summary Statistics

Cases from any source

Total	2014
Female (%)	679 (34%)
Male (%)	1335 (66%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	8.61 (6.63,10.58)
Male	24.92 (21.26,28.58)

Incidence stratified by sex

Female	1.41 (1.1,1.71)
Male	2.97 (2.48,3.47)

Incidence stratified by age

Ages 40-44	0.5 (0.06,0.94)
Ages 45-49	1.48 (0.83,2.13)
Ages 50-54	1.14 (0.61,1.67)
Ages 55-59	2.13 (1.48,2.79)
Ages 60-64	2.65 (2.03,3.28)
Ages 65-69	3.42 (2.61,4.24)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	8 (6,12)	25 (21,29)	41 (37,46)
CALIBER	18 (17,20)	45 (43,47)	84 (81,87)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	6(2,14)	9(5,17)	29(22,38)
Low	1(0,7)	18(11,27)	27(20,36)
Medium	7(2,16)	19(12,28)	37(29,47)
High	7(2,15)	27(18,37)	41(32,52)
Most deprived	18(10,28)	49(37,62)	78(64,93)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	9(6,13)	21(17,25)	40(35,45)
Scotland	2(0,10)	29(19,44)	43(31,57)
Wales	9(2,26)	54(36,79)	53(37,74)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153420, Events=132

Factor	Level	Hazard Ratio	P value
BMI	overweight	0.98 (0.66, 1.47)	0.928
BMI	obese	1.08 (0.69, 1.7)	0.735
BMI	underweight	0 (0, Inf)	0.992
smoking	previous	1.16 (0.78, 1.73)	0.462
smoking	current	2.27 (1.45, 3.57)	0.000355
hypertension	yes	1.19 (0.76, 1.85)	0.449

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1468	diabetic neuropathy/ulcers
41202	Diagnoses - main ICD10	E10.4	Insulin-dependent diabetes mellitus - With neurological complications
41202	Diagnoses - main ICD10	E11.4	Non-insulin-dependent diabetes mellitus - With neurological complications
41202	Diagnoses - main ICD10	E12.4	Malnutrition-related diabetes mellitus - With neurological complications
41202	Diagnoses - main ICD10	E13.4	Other specified diabetes mellitus - With neurological complications
41202	Diagnoses - main ICD10	E14.4	Unspecified diabetes mellitus - With neurological complications
41202	Diagnoses - main ICD10	G59.0	Diabetic mononeuropathy
41202	Diagnoses - main ICD10	G63.2	Diabetic polyneuropathy
41204	Diagnoses - secondary ICD10	E10.4	Insulin-dependent diabetes mellitus - With neurological complications
41204	Diagnoses - secondary ICD10	E11.4	Non-insulin-dependent diabetes mellitus - With neurological complications
41204	Diagnoses - secondary ICD10	E12.4	Malnutrition-related diabetes mellitus - With neurological complications
41204	Diagnoses - secondary ICD10	E13.4	Other specified diabetes mellitus - With neurological complications
41204	Diagnoses - secondary ICD10	E14.4	Unspecified diabetes mellitus - With neurological complications
41204	Diagnoses - secondary ICD10	G59.0	Diabetic mononeuropathy
41204	Diagnoses - secondary ICD10	G63.2	Diabetic polyneuropathy
40001	Underlying (primary) cause of death: ICD10	E10.4	Insulin-dependent diabetes mellitus - With neurological complications
40001	Underlying (primary) cause of death: ICD10	E11.4	Non-insulin-dependent diabetes mellitus - With neurological complications
40001	Underlying (primary) cause of death: ICD10	E12.4	Malnutrition-related diabetes mellitus - With neurological complications
40001	Underlying (primary) cause of death: ICD10	E13.4	Other specified diabetes mellitus - With neurological complications
40001	Underlying (primary) cause of death: ICD10	E14.4	Unspecified diabetes mellitus - With neurological complications
40001	Underlying (primary) cause of death: ICD10	G59.0	Diabetic mononeuropathy
40001	Underlying (primary) cause of death: ICD10	G63.2	Diabetic polyneuropathy
40002	Contributory (secondary) causes of death: ICD10	E10.4	Insulin-dependent diabetes mellitus - With neurological complications
40002	Contributory (secondary) causes of death: ICD10	E11.4	Non-insulin-dependent diabetes mellitus - With neurological complications
40002	Contributory (secondary) causes of death: ICD10	E12.4	Malnutrition-related diabetes mellitus - With neurological complications
40002	Contributory (secondary) causes of death: ICD10	E13.4	Other specified diabetes mellitus - With neurological complications
40002	Contributory (secondary) causes of death: ICD10	E14.4	Unspecified diabetes mellitus - With neurological complications
40002	Contributory (secondary) causes of death: ICD10	G59.0	Diabetic mononeuropathy
40002	Contributory (secondary) causes of death: ICD10	G63.2	Diabetic polyneuropathy
42040	GP clinical event records	C106000	Diabetes mellitus, juvenile, + neurological manifestation
42040	GP clinical event records	C106100	Diabetes mellitus, adult onset, + neurological manifestation
42040	GP clinical event records	C106.00	Diabetes mellitus with neurological manifestation
42040	GP clinical event records	C106.11	Diabetic amyotrophy
42040	GP clinical event records	C106.12	Diabetes mellitus with neuropathy
42040	GP clinical event records	C106.13	Diabetes mellitus with polyneuropathy
42040	GP clinical event records	C106y00	Other specified diabetes mellitus with neurological comps
42040	GP clinical event records	C106z00	Diabetes mellitus NOS with neurological manifestation
42040	GP clinical event records	C108200	Insulin-dependent diabetes mellitus with neurological comps
42040	GP clinical event records	C108211	Type I diabetes mellitus with neurological complications
42040	GP clinical event records	C108212	Type 1 diabetes mellitus with neurological complications
42040	GP clinical event records	C108B00	Insulin dependent diabetes mellitus with mononeuropathy
42040	GP clinical event records	C108B11	Type I diabetes mellitus with mononeuropathy
42040	GP clinical event records	C108C00	Insulin dependent diabetes mellitus with polyneuropathy
42040	GP clinical event records	C108J00	Insulin dependent diab mell with neuropathic arthropathy
42040	GP clinical event records	C108J11	Type I diabetes mellitus with neuropathic arthropathy
42040	GP clinical event records	C108J12	Type 1 diabetes mellitus with neuropathic arthropathy
42040	GP clinical event records	C109200	Non-insulin-dependent diabetes mellitus with neuro comps
42040	GP clinical event records	C109211	Type II diabetes mellitus with neurological complications
42040	GP clinical event records	C109212	Type 2 diabetes mellitus with neurological complications
42040	GP clinical event records	C109A00	Non-insulin dependent diabetes mellitus with mononeuropathy
42040	GP clinical event records	C109A11	Type II diabetes mellitus with mononeuropathy
42040	GP clinical event records	C109B00	Non-insulin dependent diabetes mellitus with polyneuropathy
42040	GP clinical event records	C109B11	Type II diabetes mellitus with polyneuropathy
42040	GP clinical event records	C109B12	Type 2 diabetes mellitus with polyneuropathy
42040	GP clinical event records	C109H00	Non-insulin dependent d m with neuropathic arthropathy
42040	GP clinical event records	C109H11	Type II diabetes mellitus with neuropathic arthropathy
42040	GP clinical event records	C109H12	Type 2 diabetes mellitus with neuropathic arthropathy
42040	GP clinical event records	C10E200	Type 1 diabetes mellitus with neurological complications
42040	GP clinical event records	C10E212	Insulin-dependent diabetes mellitus with neurological comps
42040	GP clinical event records	C10EB00	Type 1 diabetes mellitus with mononeuropathy
42040	GP clinical event records	C10EC00	Type 1 diabetes mellitus with polyneuropathy
42040	GP clinical event records	C10EC11	Type I diabetes mellitus with polyneuropathy
42040	GP clinical event records	C10EC12	Insulin dependent diabetes mellitus with polyneuropathy
42040	GP clinical event records	C10EJ00	Type 1 diabetes mellitus with neuropathic arthropathy
42040	GP clinical event records	C10F200	Type 2 diabetes mellitus with neurological complications
42040	GP clinical event records	C10F211	Type II diabetes mellitus with neurological complications
42040	GP clinical event records	C10FA00	Type 2 diabetes mellitus with mononeuropathy
42040	GP clinical event records	C10FA11	Type II diabetes mellitus with mononeuropathy
42040	GP clinical event records	C10FB00	Type 2 diabetes mellitus with polyneuropathy
42040	GP clinical event records	C10FB11	Type II diabetes mellitus with polyneuropathy
42040	GP clinical event records	C10FH00	Type 2 diabetes mellitus with neuropathic arthropathy
42040	GP clinical event records	C10FH11	Type II diabetes mellitus with neuropathic arthropathy
42040	GP clinical event records	F171100	Autonomic neuropathy due to diabetes
42040	GP clinical event records	F345000	Diabetic mononeuritis multiplex
42040	GP clinical event records	F35z000	Diabetic mononeuritis NOS
42040	GP clinical event records	F372000	Acute painful diabetic neuropathy
42040	GP clinical event records	F372100	Chronic painful diabetic neuropathy
42040	GP clinical event records	F372200	Asymptomatic diabetic neuropathy
42040	GP clinical event records	F372.00	Polyneuropathy in diabetes
42040	GP clinical event records	F372.11	Diabetic polyneuropathy
42040	GP clinical event records	F372.12	Diabetic neuropathy
42040	GP clinical event records	F381300	Myasthenic syndrome due to diabetic amyotrophy
42040	GP clinical event records	F381311	Diabetic amyotrophy
42040	GP clinical event records	F3y0.00	Diabetic mononeuropathy
42040	GP clinical event records	M271100	Neuropathic diabetic ulcer - foot
42040	GP clinical event records	X00Al	Diabetic mononeuropathy
42040	GP clinical event records	XE15n	Myasthenic syndrome due to diabetic amyotrophy
42040	GP clinical event records	XE10H	Diabetes mellitus with neurological manifestation