| Name |
Dysmenorrhoea (dysmenorrhoea) |
| Category |
Genitourinary |
| Sex |
|
| Adult |
Yes |
| UUID |
e0ce2cc5-81b2-464b-813b-ff3a99c348a7 |
| Definition |
Painful menstruation. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
5954 |
| Female (%) |
5954 (100%) |
| Male (%) |
0 (0%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
326.99 (315.02,338.96) |
| Male |
0.0 (0.0,0.0) |
Incidence stratified by sex
| Female |
3.33 (2.85,3.81) |
| Male |
0.0 (0.0,0.0) |
Incidence stratified by age
| Ages 40-44 |
9.96 (7.96,11.95) |
| Ages 45-49 |
4.6 (3.44,5.77) |
| Ages 50-54 |
1.3 (0.73,1.87) |
| Ages 55-59 |
0.37 (0.1,0.64) |
| Ages 60-64 |
0.0 (0.0,0.0) |
| Ages 65-69 |
0.0 (0.0,0.0) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
340 (323,358) |
224 (214,235) |
88 (83,94) |
| CALIBER |
919 (908,930) |
674 (663,685) |
282 (274,290) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
297(260,337) |
222(199,247) |
86(73,99) |
| Low |
337(298,380) |
209(186,233) |
79(68,92) |
| Medium |
312(276,352) |
220(197,245) |
92(80,106) |
| High |
348(313,387) |
232(209,257) |
91(78,106) |
| Most deprived |
389(353,428) |
239(215,266) |
95(81,111) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
349(330,368) |
229(217,241) |
88(82,95) |
| Scotland |
195(161,235) |
179(153,207) |
96(79,115) |
| Wales |
502(428,584) |
255(216,299) |
75(56,98) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153508, Events=407
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.96 (0.75, 1.22) |
0.716 |
| BMI |
obese |
1.36 (1.06, 1.76) |
0.0167 |
| BMI |
underweight |
0 (0, Inf) |
0.986 |
| smoking |
previous |
1.37 (1.1, 1.7) |
0.00438 |
| smoking |
current |
2.14 (1.6, 2.85) |
2.26e-07 |
| hypertension |
yes |
1.88 (1.53, 2.31) |
1.47e-09 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1664 |
dysmenorrhoea / dysmenorrhea |
| 41202 |
Diagnoses - main ICD10 |
N94.4 |
Primary dysmenorrhoea |
| 41202 |
Diagnoses - main ICD10 |
N94.5 |
Secondary dysmenorrhoea |
| 41202 |
Diagnoses - main ICD10 |
N94.6 |
Dysmenorrhoea, unspecified |
| 41204 |
Diagnoses - secondary ICD10 |
N94.4 |
Primary dysmenorrhoea |
| 41204 |
Diagnoses - secondary ICD10 |
N94.5 |
Secondary dysmenorrhoea |
| 41204 |
Diagnoses - secondary ICD10 |
N94.6 |
Dysmenorrhoea, unspecified |
| 40001 |
Underlying (primary) cause of death: ICD10 |
N94.4 |
Primary dysmenorrhoea |
| 40001 |
Underlying (primary) cause of death: ICD10 |
N94.5 |
Secondary dysmenorrhoea |
| 40001 |
Underlying (primary) cause of death: ICD10 |
N94.6 |
Dysmenorrhoea, unspecified |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
N94.4 |
Primary dysmenorrhoea |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
N94.5 |
Secondary dysmenorrhoea |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
N94.6 |
Dysmenorrhoea, unspecified |
| 42040 |
GP clinical event records |
1574.00 |
H/O: dysmenorrhoea |
| 42040 |
GP clinical event records |
1574.11 |
H/O: painful periods |
| 42040 |
GP clinical event records |
Eu45y11 |
[X]Psychogenic dysmenorrhoea |
| 42040 |
GP clinical event records |
K583000 |
Primary dysmenorrhoea |
| 42040 |
GP clinical event records |
K583100 |
Secondary dysmenorrhoea |
| 42040 |
GP clinical event records |
K583.00 |
Dysmenorrhoea |
| 42040 |
GP clinical event records |
K583.11 |
Painful menorrhoea |
| 42040 |
GP clinical event records |
K583.12 |
Painful menstruation |
| 42040 |
GP clinical event records |
K583.13 |
Period pains |
| 42040 |
GP clinical event records |
K583.14 |
Spasmodic dysmenorrhoea |
| 42040 |
GP clinical event records |
XE0ek |
Dysmenorrhoea |
| 42040 |
GP clinical event records |
X408t |
Primary dysmenorrhoea |
| 42040 |
GP clinical event records |
XE1Zo |
[X]Other somatoform disorders |
| 42040 |
GP clinical event records |
X408u |
Secondary dysmenorrhoea |