Metadata

Name Ear and Upper Respiratory Tract Infections (ear_urti)
Category Infections
Sex
Adult Yes
UUID 1a9faafe-8dbc-4264-9214-1bbd74a64fc9
Definition Ear and Upper Respiratory Tract Infections

Ontologies

SNOMED-CT 54150009
FinnGen J10_ACUTEUPPERINFEC

Key Summary Statistics

Cases from any source

Total 17601
Female (%) 9781 (56%)
Male (%) 7820 (44%)

Year first recorded

ear_urti year of first event

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Cross-sourced ear_urti cases

Incidence & prevalence

Sex and age-stratified incidence and prevalence of ear_urti

Baseline prevalence stratified by sex

Female 262.51 (251.75,273.27)
Male 254.79 (243.23,266.34)

Incidence stratified by sex

Female 9.3 (8.5,10.11)
Male 9.19 (8.31,10.06)

Incidence stratified by age

Ages 40-44 10.45 (8.41,12.49)
Ages 45-49 7.77 (6.26,9.27)
Ages 50-54 8.93 (7.43,10.42)
Ages 55-59 9.58 (8.18,10.99)
Ages 60-64 9.28 (8.1,10.47)
Ages 65-69 9.55 (8.17,10.92)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

CALIBER and UKB ear_urti prevalence comparison for multiple age groups

Population Ages 40-49 Ages 50-59 Ages 60-69
UK Biobank 160 (148,173) 138 (129,148) 146 (138,154)
CALIBER 154 (151,158) 132 (128,135) 132 (129,136)

Stratified by age and Townsend deprivation status

Deprivation status Ages 40-49 Ages 50-59 Ages 60-69
Least deprived 133(108,163) 116(98,136) 129(114,146)
Low 117(93,145) 119(101,140) 144(128,162)
Medium 157(130,188) 137(118,159) 131(115,148)
High 162(137,191) 138(119,160) 146(129,165)
Most deprived 210(183,240) 179(157,203) 185(165,208)

Stratified by age and country

Country Ages 40-49 Ages 50-59 Ages 60-69
England 159(145,173) 139(129,149) 151(142,160)
Scotland 146(115,183) 132(109,159) 114(95,137)
Wales 196(149,254) 142(111,179) 141(115,172)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153969, Events=129

Factor Level Hazard Ratio P value
BMI overweight 1.18 (0.74, 1.86) 0.489
BMI obese 1.91 (1.2, 3.06) 0.00685
BMI underweight 0 (0, Inf) 0.995
smoking previous 1.29 (0.88, 1.87) 0.189
smoking current 1.41 (0.81, 2.45) 0.23
hypertension yes 1.93 (1.34, 2.77) 0.000403

Risk factors analysis forest plot

Definition

UK Biobank field id Description Code Value
20002 Non-cancer illness code, self-reported 1574 diphtheria
20002 Non-cancer illness code, self-reported 1567 infectious mononucleosis / glandular fever / epstein barr virus (ebv)
20002 Non-cancer illness code, self-reported 1418 chronic laryngitis
20002 Non-cancer illness code, self-reported 1598 tonsiltis
41202 Diagnoses - main ICD10 A18.6 Tuberculosis of ear
41202 Diagnoses - main ICD10 A36.0 Pharyngeal diphtheria
41202 Diagnoses - main ICD10 A36.1 Nasopharyngeal diphtheria
41202 Diagnoses - main ICD10 A36.2 Laryngeal diphtheria
41202 Diagnoses - main ICD10 A54.5 Gonococcal pharyngitis
41202 Diagnoses - main ICD10 A56.4 Chlamydial infection of pharynx
41202 Diagnoses - main ICD10 B05.3 Measles complicated by otitis media
41202 Diagnoses - main ICD10 B27 Infectious mononucleosis
41202 Diagnoses - main ICD10 B44.2 Tonsillar aspergillosis
41202 Diagnoses - main ICD10 B87.3 Nasopharyngeal myiasis
41202 Diagnoses - main ICD10 B87.4 Aural myiasis
41202 Diagnoses - main ICD10 H60 Otitis externa
41202 Diagnoses - main ICD10 H62.0 Otitis externa in bacterial diseases classified elsewhere
41202 Diagnoses - main ICD10 H62.1 Otitis externa in viral diseases classified elsewhere
41202 Diagnoses - main ICD10 H62.2 Otitis externa in mycoses
41202 Diagnoses - main ICD10 H62.3 Otitis externa in other infectious and parasitic diseases classified elsewhere
41202 Diagnoses - main ICD10 H62.4 Otitis externa in other diseases classified elsewhere
41202 Diagnoses - main ICD10 H65 Nonsuppurative otitis media
41202 Diagnoses - main ICD10 H66 Suppurative and unspecified otitis media
41202 Diagnoses - main ICD10 H67 Otitis media in diseases classified elsewhere
41202 Diagnoses - main ICD10 H70 Mastoiditis and related conditions
41202 Diagnoses - main ICD10 H73.0 Acute myringitis
41202 Diagnoses - main ICD10 H73.1 Chronic myringitis
41202 Diagnoses - main ICD10 H75.0 Mastoiditis in infectious and parasitic diseases classified elsewhere
41202 Diagnoses - main ICD10 J00 Acute nasopharyngitis [common cold]
41202 Diagnoses - main ICD10 J01 Acute sinusitis
41202 Diagnoses - main ICD10 J02 Acute pharyngitis
41202 Diagnoses - main ICD10 J03 Acute tonsillitis
41202 Diagnoses - main ICD10 J04 Acute laryngitis and tracheitis
41202 Diagnoses - main ICD10 J05 Acute obstructive laryngitis [croup] and epiglottitis
41202 Diagnoses - main ICD10 J06 Acute upper respiratory infections of multiple and unspecified sites
41202 Diagnoses - main ICD10 J34.0 Abscess, furuncle and carbuncle of nose
41202 Diagnoses - main ICD10 J36 Peritonsillar abscess
41202 Diagnoses - main ICD10 J37 Chronic laryngitis and laryngotracheitis
41202 Diagnoses - main ICD10 J39.0 Retropharyngeal and parapharyngeal abscess
41202 Diagnoses - main ICD10 J39.1 Other abscess of pharynx
41204 Diagnoses - secondary ICD10 A18.6 Tuberculosis of ear
41204 Diagnoses - secondary ICD10 A36.0 Pharyngeal diphtheria
41204 Diagnoses - secondary ICD10 A36.1 Nasopharyngeal diphtheria
41204 Diagnoses - secondary ICD10 A36.2 Laryngeal diphtheria
41204 Diagnoses - secondary ICD10 A54.5 Gonococcal pharyngitis
41204 Diagnoses - secondary ICD10 A56.4 Chlamydial infection of pharynx
41204 Diagnoses - secondary ICD10 B05.3 Measles complicated by otitis media
41204 Diagnoses - secondary ICD10 B27 Infectious mononucleosis
41204 Diagnoses - secondary ICD10 B44.2 Tonsillar aspergillosis
41204 Diagnoses - secondary ICD10 B87.3 Nasopharyngeal myiasis
41204 Diagnoses - secondary ICD10 B87.4 Aural myiasis
41204 Diagnoses - secondary ICD10 H60 Otitis externa
41204 Diagnoses - secondary ICD10 H62.0 Otitis externa in bacterial diseases classified elsewhere
41204 Diagnoses - secondary ICD10 H62.1 Otitis externa in viral diseases classified elsewhere
41204 Diagnoses - secondary ICD10 H62.2 Otitis externa in mycoses
41204 Diagnoses - secondary ICD10 H62.3 Otitis externa in other infectious and parasitic diseases classified elsewhere
41204 Diagnoses - secondary ICD10 H62.4 Otitis externa in other diseases classified elsewhere
41204 Diagnoses - secondary ICD10 H65 Nonsuppurative otitis media
41204 Diagnoses - secondary ICD10 H66 Suppurative and unspecified otitis media
41204 Diagnoses - secondary ICD10 H67 Otitis media in diseases classified elsewhere
41204 Diagnoses - secondary ICD10 H70 Mastoiditis and related conditions
41204 Diagnoses - secondary ICD10 H73.0 Acute myringitis
41204 Diagnoses - secondary ICD10 H73.1 Chronic myringitis
41204 Diagnoses - secondary ICD10 H75.0 Mastoiditis in infectious and parasitic diseases classified elsewhere
41204 Diagnoses - secondary ICD10 J00 Acute nasopharyngitis [common cold]
41204 Diagnoses - secondary ICD10 J01 Acute sinusitis
41204 Diagnoses - secondary ICD10 J02 Acute pharyngitis
41204 Diagnoses - secondary ICD10 J03 Acute tonsillitis
41204 Diagnoses - secondary ICD10 J04 Acute laryngitis and tracheitis
41204 Diagnoses - secondary ICD10 J05 Acute obstructive laryngitis [croup] and epiglottitis
41204 Diagnoses - secondary ICD10 J06 Acute upper respiratory infections of multiple and unspecified sites
41204 Diagnoses - secondary ICD10 J34.0 Abscess, furuncle and carbuncle of nose
41204 Diagnoses - secondary ICD10 J36 Peritonsillar abscess
41204 Diagnoses - secondary ICD10 J37 Chronic laryngitis and laryngotracheitis
41204 Diagnoses - secondary ICD10 J39.0 Retropharyngeal and parapharyngeal abscess
41204 Diagnoses - secondary ICD10 J39.1 Other abscess of pharynx
40001 Underlying (primary) cause of death: ICD10 A18.6 Tuberculosis of ear
40001 Underlying (primary) cause of death: ICD10 A36.0 Pharyngeal diphtheria
40001 Underlying (primary) cause of death: ICD10 A36.1 Nasopharyngeal diphtheria
40001 Underlying (primary) cause of death: ICD10 A36.2 Laryngeal diphtheria
40001 Underlying (primary) cause of death: ICD10 A54.5 Gonococcal pharyngitis
40001 Underlying (primary) cause of death: ICD10 A56.4 Chlamydial infection of pharynx
40001 Underlying (primary) cause of death: ICD10 B05.3 Measles complicated by otitis media
40001 Underlying (primary) cause of death: ICD10 B27 Infectious mononucleosis
40001 Underlying (primary) cause of death: ICD10 B44.2 Tonsillar aspergillosis
40001 Underlying (primary) cause of death: ICD10 B87.3 Nasopharyngeal myiasis
40001 Underlying (primary) cause of death: ICD10 B87.4 Aural myiasis
40001 Underlying (primary) cause of death: ICD10 H60 Otitis externa
40001 Underlying (primary) cause of death: ICD10 H62.0 Otitis externa in bacterial diseases classified elsewhere
40001 Underlying (primary) cause of death: ICD10 H62.1 Otitis externa in viral diseases classified elsewhere
40001 Underlying (primary) cause of death: ICD10 H62.2 Otitis externa in mycoses
40001 Underlying (primary) cause of death: ICD10 H62.3 Otitis externa in other infectious and parasitic diseases classified elsewhere
40001 Underlying (primary) cause of death: ICD10 H62.4 Otitis externa in other diseases classified elsewhere
40001 Underlying (primary) cause of death: ICD10 H65 Nonsuppurative otitis media
40001 Underlying (primary) cause of death: ICD10 H66 Suppurative and unspecified otitis media
40001 Underlying (primary) cause of death: ICD10 H67 Otitis media in diseases classified elsewhere
40001 Underlying (primary) cause of death: ICD10 H70 Mastoiditis and related conditions
40001 Underlying (primary) cause of death: ICD10 H73.0 Acute myringitis
40001 Underlying (primary) cause of death: ICD10 H73.1 Chronic myringitis
40001 Underlying (primary) cause of death: ICD10 H75.0 Mastoiditis in infectious and parasitic diseases classified elsewhere
40001 Underlying (primary) cause of death: ICD10 J00 Acute nasopharyngitis [common cold]
40001 Underlying (primary) cause of death: ICD10 J01 Acute sinusitis
40001 Underlying (primary) cause of death: ICD10 J02 Acute pharyngitis
40001 Underlying (primary) cause of death: ICD10 J03 Acute tonsillitis
40001 Underlying (primary) cause of death: ICD10 J04 Acute laryngitis and tracheitis
40001 Underlying (primary) cause of death: ICD10 J05 Acute obstructive laryngitis [croup] and epiglottitis
40001 Underlying (primary) cause of death: ICD10 J06 Acute upper respiratory infections of multiple and unspecified sites
40001 Underlying (primary) cause of death: ICD10 J34.0 Abscess, furuncle and carbuncle of nose
40001 Underlying (primary) cause of death: ICD10 J36 Peritonsillar abscess
40001 Underlying (primary) cause of death: ICD10 J37 Chronic laryngitis and laryngotracheitis
40001 Underlying (primary) cause of death: ICD10 J39.0 Retropharyngeal and parapharyngeal abscess
40001 Underlying (primary) cause of death: ICD10 J39.1 Other abscess of pharynx
40002 Contributory (secondary) causes of death: ICD10 A18.6 Tuberculosis of ear
40002 Contributory (secondary) causes of death: ICD10 A36.0 Pharyngeal diphtheria
40002 Contributory (secondary) causes of death: ICD10 A36.1 Nasopharyngeal diphtheria
40002 Contributory (secondary) causes of death: ICD10 A36.2 Laryngeal diphtheria
40002 Contributory (secondary) causes of death: ICD10 A54.5 Gonococcal pharyngitis
40002 Contributory (secondary) causes of death: ICD10 A56.4 Chlamydial infection of pharynx
40002 Contributory (secondary) causes of death: ICD10 B05.3 Measles complicated by otitis media
40002 Contributory (secondary) causes of death: ICD10 B27 Infectious mononucleosis
40002 Contributory (secondary) causes of death: ICD10 B44.2 Tonsillar aspergillosis
40002 Contributory (secondary) causes of death: ICD10 B87.3 Nasopharyngeal myiasis
40002 Contributory (secondary) causes of death: ICD10 B87.4 Aural myiasis
40002 Contributory (secondary) causes of death: ICD10 H60 Otitis externa
40002 Contributory (secondary) causes of death: ICD10 H62.0 Otitis externa in bacterial diseases classified elsewhere
40002 Contributory (secondary) causes of death: ICD10 H62.1 Otitis externa in viral diseases classified elsewhere
40002 Contributory (secondary) causes of death: ICD10 H62.2 Otitis externa in mycoses
40002 Contributory (secondary) causes of death: ICD10 H62.3 Otitis externa in other infectious and parasitic diseases classified elsewhere
40002 Contributory (secondary) causes of death: ICD10 H62.4 Otitis externa in other diseases classified elsewhere
40002 Contributory (secondary) causes of death: ICD10 H65 Nonsuppurative otitis media
40002 Contributory (secondary) causes of death: ICD10 H66 Suppurative and unspecified otitis media
40002 Contributory (secondary) causes of death: ICD10 H67 Otitis media in diseases classified elsewhere
40002 Contributory (secondary) causes of death: ICD10 H70 Mastoiditis and related conditions
40002 Contributory (secondary) causes of death: ICD10 H73.0 Acute myringitis
40002 Contributory (secondary) causes of death: ICD10 H73.1 Chronic myringitis
40002 Contributory (secondary) causes of death: ICD10 H75.0 Mastoiditis in infectious and parasitic diseases classified elsewhere
40002 Contributory (secondary) causes of death: ICD10 J00 Acute nasopharyngitis [common cold]
40002 Contributory (secondary) causes of death: ICD10 J01 Acute sinusitis
40002 Contributory (secondary) causes of death: ICD10 J02 Acute pharyngitis
40002 Contributory (secondary) causes of death: ICD10 J03 Acute tonsillitis
40002 Contributory (secondary) causes of death: ICD10 J04 Acute laryngitis and tracheitis
40002 Contributory (secondary) causes of death: ICD10 J05 Acute obstructive laryngitis [croup] and epiglottitis
40002 Contributory (secondary) causes of death: ICD10 J06 Acute upper respiratory infections of multiple and unspecified sites
40002 Contributory (secondary) causes of death: ICD10 J34.0 Abscess, furuncle and carbuncle of nose
40002 Contributory (secondary) causes of death: ICD10 J36 Peritonsillar abscess
40002 Contributory (secondary) causes of death: ICD10 J37 Chronic laryngitis and laryngotracheitis
40002 Contributory (secondary) causes of death: ICD10 J39.0 Retropharyngeal and parapharyngeal abscess
40002 Contributory (secondary) causes of death: ICD10 J39.1 Other abscess of pharynx