Metadata

Name Anorexia and bulimia nervosa (eating_dz)
Category Psychiatric
Sex
Adult Yes
UUID ffc208d4-641b-41fb-97b7-c03309c03ac7
Definition Mental disorders defined by abnormal eating behaviors that negatively affect a person’s physical or mental health. Anorexia nervosa: the afflicted individual has an intense fear of gaining weight and restrict food or overexercise to manage this fear. Bulimia nervosa: the afflicted individual eats a lot (binging) then tries to rid themselves of the food (purging).

Ontologies

Disease Ontology (DOID) DOID_8670
GWAS Catalogue EFO_0005203
MeSH D001068
SNOMED-CT 72366004
FinnGen F5_EATING

Key Summary Statistics

Cases from any source

Total 843
Female (%) 790 (94%)
Male (%) 53 (6%)

Year first recorded

eating_dz year of first event

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Cross-sourced eating_dz cases

Incidence & prevalence

Sex and age-stratified incidence and prevalence of eating_dz

Baseline prevalence stratified by sex

Female 42.08 (37.73,46.44)
Male 3.64 (2.24,5.04)

Incidence stratified by sex

Female 0.21 (0.09,0.33)
Male 0.02 (-0.02,0.06)

Incidence stratified by age

Ages 40-44 0.2 (-0.08,0.48)
Ages 45-49 0.3 (0.01,0.59)
Ages 50-54 0.06 (-0.06,0.19)
Ages 55-59 0.0 (0.0,0.0)
Ages 60-64 0.12 (-0.02,0.25)
Ages 65-69 0.15 (-0.02,0.32)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

CALIBER and UKB eating_dz prevalence comparison for multiple age groups

Population Ages 40-49 Ages 50-59 Ages 60-69
UK Biobank 41 (36,48) 21 (17,24) 12 (10,14)
CALIBER 50 (48,52) 28 (26,29) 12 (11,14)

Stratified by age and Townsend deprivation status

Deprivation status Ages 40-49 Ages 50-59 Ages 60-69
Least deprived 31(20,46) 18(12,27) 9(5,14)
Low 32(21,48) 23(16,32) 12(8,18)
Medium 48(34,65) 16(10,23) 11(7,16)
High 47(35,63) 15(10,23) 14(9,20)
Most deprived 45(33,60) 30(22,41) 14(9,21)

Stratified by age and country

Country Ages 40-49 Ages 50-59 Ages 60-69
England 38(32,45) 21(17,25) 12(10,15)
Scotland 65(46,90) 29(19,42) 15(9,24)
Wales 36(19,63) 3(0,12) 1(0,8)

Definition

UK Biobank field id Description Code Value
20002 Non-cancer illness code, self-reported 1470 anorexia/bulimia/other eating disorder
41202 Diagnoses - main ICD10 F50.0 Anorexia nervosa
41202 Diagnoses - main ICD10 F50.1 Atypical anorexia nervosa
41202 Diagnoses - main ICD10 F50.2 Bulimia nervosa
41202 Diagnoses - main ICD10 F50.3 Atypical bulimia nervosa
41204 Diagnoses - secondary ICD10 F50.0 Anorexia nervosa
41204 Diagnoses - secondary ICD10 F50.1 Atypical anorexia nervosa
41204 Diagnoses - secondary ICD10 F50.2 Bulimia nervosa
41204 Diagnoses - secondary ICD10 F50.3 Atypical bulimia nervosa
40001 Underlying (primary) cause of death: ICD10 F50.0 Anorexia nervosa
40001 Underlying (primary) cause of death: ICD10 F50.1 Atypical anorexia nervosa
40001 Underlying (primary) cause of death: ICD10 F50.2 Bulimia nervosa
40001 Underlying (primary) cause of death: ICD10 F50.3 Atypical bulimia nervosa
40002 Contributory (secondary) causes of death: ICD10 F50.0 Anorexia nervosa
40002 Contributory (secondary) causes of death: ICD10 F50.1 Atypical anorexia nervosa
40002 Contributory (secondary) causes of death: ICD10 F50.2 Bulimia nervosa
40002 Contributory (secondary) causes of death: ICD10 F50.3 Atypical bulimia nervosa
42040 GP clinical event records 1467.00 H/O: anorexia nervosa
42040 GP clinical event records E271.00 Anorexia nervosa
42040 GP clinical event records E275100 Bulimia (non-organic overeating)
42040 GP clinical event records Eu50000 [X]Anorexia nervosa
42040 GP clinical event records Eu50100 [X]Atypical anorexia nervosa
42040 GP clinical event records Eu50200 [X]Bulimia nervosa
42040 GP clinical event records Eu50211 [X]Bulimia NOS
42040 GP clinical event records Eu50300 [X]Atypical bulimia nervosa
42040 GP clinical event records R036011 [D]Bulimia NOS