Erectile dysfunction

Metadata

Name	Erectile dysfunction (ED)
Category	Genitourinary
Sex
Adult	Yes
UUID	0fedde63-0820-4dcb-9568-45e765f54efc
Definition	Persistent or recurrent inability to achieve or to maintain an erection during sexual activity.

Ontologies

Disease Ontology (DOID)	DOID_1875
GWAS Catalogue	EFO_0004234
MeSH	D007172
SNOMED-CT	397803000
FinnGen	ERECTILE_DYSFUNCTION

Key Summary Statistics

Cases from any source

Total	19869
Female (%)	0 (0%)
Male (%)	19869 (100%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	0.0 (0.0,0.0)
Male	879.02 (858.25,899.78)

Incidence stratified by sex

Female	0.0 (0.0,0.0)
Male	135.69 (132.14,139.24)

Incidence stratified by age

Ages 40-44	31.4 (27.88,34.92)
Ages 45-49	37.78 (34.46,41.11)
Ages 50-54	47.16 (43.7,50.62)
Ages 55-59	59.25 (55.71,62.8)
Ages 60-64	70.54 (67.18,73.89)
Ages 65-69	73.34 (69.4,77.28)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	397 (377,417)	728 (706,750)	1088 (1066,1110)
CALIBER	814 (804,825)	1551 (1535,	2306 (2284,

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	320(278,366)	676(629,725)	1042(995,1090)
Low	335(292,384)	633(587,682)	1071(1024,1119)
Medium	330(288,376)	700(652,751)	1091(1043,1142)
High	426(382,474)	746(697,798)	1115(1063,1168)
Most deprived	508(465,554)	869(817,922)	1135(1081,1191)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	409(387,433)	760(735,786)	1126(1101,1151)
Scotland	235(191,285)	401(357,447)	646(596,699)
Wales	514(432,607)	957(870,1051)	1341(1254,1433)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153508, Events=407

Factor	Level	Hazard Ratio	P value
BMI	overweight	0.96 (0.75, 1.22)	0.716
BMI	obese	1.36 (1.06, 1.76)	0.0167
BMI	underweight	0 (0, Inf)	0.986
smoking	previous	1.37 (1.1, 1.7)	0.00438
smoking	current	2.14 (1.6, 2.85)	2.26e-07
hypertension	yes	1.88 (1.53, 2.31)	1.47e-09

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1518	erectile dysfunction / impotence
41202	Diagnoses - main ICD10	F52.2	Failure of genital response
41202	Diagnoses - main ICD10	N48.4	Impotence of organic origin
41204	Diagnoses - secondary ICD10	F52.2	Failure of genital response
41204	Diagnoses - secondary ICD10	N48.4	Impotence of organic origin
40001	Underlying (primary) cause of death: ICD10	F52.2	Failure of genital response
40001	Underlying (primary) cause of death: ICD10	N48.4	Impotence of organic origin
40002	Contributory (secondary) causes of death: ICD10	F52.2	Failure of genital response
40002	Contributory (secondary) causes of death: ICD10	N48.4	Impotence of organic origin
42040	GP clinical event records	1ABB.00	Cannot get an erection
42040	GP clinical event records	1ABC.00	Cannot sustain an erection
42040	GP clinical event records	1D1B.00	C/O erectile dysfunction
42040	GP clinical event records	7A6G000	Revascularisation for impotence
42040	GP clinical event records	7A6G500	Ligation of penile veins for impotence
42040	GP clinical event records	7C25B00	Penile injection to produce erection
42040	GP clinical event records	7C25E00	Treatment of erectile dysfunction NEC
42040	GP clinical event records	7C25F00	Operations on penis for erectile dysfunction NEC
42040	GP clinical event records	8BB4.00	Erect dysf unresponsiv to phosphodiesterase-5 inhibitor
42040	GP clinical event records	8HTj.00	Referral to erectile dysfunction clinic
42040	GP clinical event records	E227300	Impotence
42040	GP clinical event records	E227311	Erectile dysfunction
42040	GP clinical event records	Eu52200	[X]Failure of genital response
42040	GP clinical event records	Eu52212	[X]Male erectile disorder
42040	GP clinical event records	Eu52213	[X]Psychogenic impotence
42040	GP clinical event records	K27y100	Impotence of organic origin
42040	GP clinical event records	K27y700	Erectile dysfunction due to diabetes mellitus
42040	GP clinical event records	Z9E9.00	Provision of device for impotence
42040	GP clinical event records	ZG43600	Advice on technique for impotence
42040	GP clinical event records	XaXgw	C/O erectile dysfunction
42040	GP clinical event records	XaMsd	Operations on penis for erectile dysfunction NEC
42040	GP clinical event records	X76MO	Cannot sustain an erection
42040	GP clinical event records	XaXgy	Erectile dysfunction unresponsive to phosphodiesterase-5 inhibitor
42040	GP clinical event records	XaMBP	Treatment of erectile dysfunction NEC
42040	GP clinical event records	Xaa8r	Erectile dysfunction due to diabetes mellitus
42040	GP clinical event records	XaL47	Referral to erectile dysfunction clinic
42040	GP clinical event records	X76ME	Cannot get an erection