Encephalitis

Metadata

Name	Encephalitis (enceph)
Category	Infections
Sex
Adult	Yes
UUID	600eac97-2013-4174-8fa1-2e067cf1432e
Definition	A brain disease that is characterized as an acute inflammation of the brain with flu-like symptoms.

Ontologies

Disease Ontology (DOID)	DOID_9588
MeSH	D004660
SNOMED-CT	45170000
FinnGen	ENCEPHALITIS

Key Summary Statistics

Cases from any source

Total	530
Female (%)	269 (51%)
Male (%)	261 (49%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	6.13 (4.46,7.8)
Male	6.44 (4.58,8.3)

Incidence stratified by sex

Female	0.12 (0.03,0.21)
Male	0.23 (0.09,0.37)

Incidence stratified by age

Ages 40-44	0.0 (0.0,0.0)
Ages 45-49	0.15 (-0.06,0.35)
Ages 50-54	0.25 (0.01,0.5)
Ages 55-59	0.26 (0.03,0.49)
Ages 60-64	0.15 (0.0,0.3)
Ages 65-69	0.15 (-0.02,0.32)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	1 (0,2)	3 (2,5)	3 (2,4)
CALIBER	2 (2,3)	–	4 (3,4)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	2(0,9)	5(2,10)	5(2,9)
Low	2(0,9)	2(0,6)	4(2,8)
Medium	1(0,6)	2(0,7)	1(0,4)
High	0(NaN,NaN)	2(0,5)	2(0,5)
Most deprived	0(NaN,NaN)	4(2,10)	3(1,8)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	1(0,2)	3(2,5)	3(2,4)
Scotland	0(NaN,NaN)	4(1,10)	4(1,10)
Wales	4(0,21)	2(0,12)	6(2,15)

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1246	encephalitis
41202	Diagnoses - main ICD10	A83	Mosquito-borne viral encephalitis
41202	Diagnoses - main ICD10	A84	Tick-borne viral encephalitis
41202	Diagnoses - main ICD10	A85	Other viral encephalitis, not elsewhere classified
41202	Diagnoses - main ICD10	A86	Unspecified viral encephalitis
41202	Diagnoses - main ICD10	B00.4	Herpesviral encephalitis
41202	Diagnoses - main ICD10	B01.1	Varicella encephalitis
41202	Diagnoses - main ICD10	B02.0	Zoster encephalitis
41202	Diagnoses - main ICD10	B05.0	Measles complicated by encephalitis
41202	Diagnoses - main ICD10	B26.2	Mumps encephalitis
41202	Diagnoses - main ICD10	B94.1	Sequelae of viral encephalitis
41204	Diagnoses - secondary ICD10	A83	Mosquito-borne viral encephalitis
41204	Diagnoses - secondary ICD10	A84	Tick-borne viral encephalitis
41204	Diagnoses - secondary ICD10	A85	Other viral encephalitis, not elsewhere classified
41204	Diagnoses - secondary ICD10	A86	Unspecified viral encephalitis
41204	Diagnoses - secondary ICD10	B00.4	Herpesviral encephalitis
41204	Diagnoses - secondary ICD10	B01.1	Varicella encephalitis
41204	Diagnoses - secondary ICD10	B02.0	Zoster encephalitis
41204	Diagnoses - secondary ICD10	B05.0	Measles complicated by encephalitis
41204	Diagnoses - secondary ICD10	B26.2	Mumps encephalitis
41204	Diagnoses - secondary ICD10	B94.1	Sequelae of viral encephalitis
40001	Underlying (primary) cause of death: ICD10	A83	Mosquito-borne viral encephalitis
40001	Underlying (primary) cause of death: ICD10	A84	Tick-borne viral encephalitis
40001	Underlying (primary) cause of death: ICD10	A85	Other viral encephalitis, not elsewhere classified
40001	Underlying (primary) cause of death: ICD10	A86	Unspecified viral encephalitis
40001	Underlying (primary) cause of death: ICD10	B00.4	Herpesviral encephalitis
40001	Underlying (primary) cause of death: ICD10	B01.1	Varicella encephalitis
40001	Underlying (primary) cause of death: ICD10	B02.0	Zoster encephalitis
40001	Underlying (primary) cause of death: ICD10	B05.0	Measles complicated by encephalitis
40001	Underlying (primary) cause of death: ICD10	B26.2	Mumps encephalitis
40001	Underlying (primary) cause of death: ICD10	B94.1	Sequelae of viral encephalitis
40002	Contributory (secondary) causes of death: ICD10	A83	Mosquito-borne viral encephalitis
40002	Contributory (secondary) causes of death: ICD10	A84	Tick-borne viral encephalitis
40002	Contributory (secondary) causes of death: ICD10	A85	Other viral encephalitis, not elsewhere classified
40002	Contributory (secondary) causes of death: ICD10	A86	Unspecified viral encephalitis
40002	Contributory (secondary) causes of death: ICD10	B00.4	Herpesviral encephalitis
40002	Contributory (secondary) causes of death: ICD10	B01.1	Varicella encephalitis
40002	Contributory (secondary) causes of death: ICD10	B02.0	Zoster encephalitis
40002	Contributory (secondary) causes of death: ICD10	B05.0	Measles complicated by encephalitis
40002	Contributory (secondary) causes of death: ICD10	B26.2	Mumps encephalitis
40002	Contributory (secondary) causes of death: ICD10	B94.1	Sequelae of viral encephalitis