| Name |
Endometrial hyperplasia and hypertrophy (endometrial_hyper) |
| Category |
Genitourinary |
| Sex |
|
| Adult |
Yes |
| UUID |
8ab543f3-c282-4222-9e57-0304530e4721 |
| Definition |
Endometrial hyperplasia is a condition of the female reproductive system. The lining of the uterus (endometrium) becomes unusually thick because of having too many cells (hyperplasia). |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
3576 |
| Female (%) |
3576 (100%) |
| Male (%) |
0 (0%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
90.06 (83.7,96.42) |
| Male |
0.0 (0.0,0.0) |
Incidence stratified by sex
| Female |
4.6 (4.04,5.16) |
| Male |
0.0 (0.0,0.0) |
Incidence stratified by age
| Ages 40-44 |
3.94 (2.7,5.17) |
| Ages 45-49 |
4.55 (3.41,5.69) |
| Ages 50-54 |
2.93 (2.08,3.78) |
| Ages 55-59 |
2.2 (1.53,2.86) |
| Ages 60-64 |
1.43 (0.97,1.89) |
| Ages 65-69 |
1.71 (1.14,2.29) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
57 (51,65) |
66 (61,73) |
55 (50,60) |
| CALIBER |
124 (120,128) |
162 (157,168) |
131 (125,136) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
54(39,73) |
66(53,80) |
54(44,65) |
| Low |
55(40,74) |
70(57,85) |
56(47,67) |
| Medium |
47(33,63) |
67(55,81) |
55(45,66) |
| High |
54(41,71) |
67(54,81) |
52(42,63) |
| Most deprived |
73(58,91) |
63(51,78) |
58(47,70) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
59(51,67) |
72(65,79) |
58(53,64) |
| Scotland |
21(11,36) |
26(17,38) |
32(23,44) |
| Wales |
103(71,144) |
82(60,108) |
53(38,73) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153321, Events=259
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
1.47 (1.07, 2.01) |
0.0165 |
| BMI |
obese |
2.46 (1.81, 3.35) |
1.19e-08 |
| BMI |
underweight |
0 (0, Inf) |
0.998 |
| smoking |
previous |
1.06 (0.81, 1.39) |
0.676 |
| smoking |
current |
0.75 (0.46, 1.22) |
0.25 |
| hypertension |
yes |
0.83 (0.58, 1.19) |
0.31 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 41202 |
Diagnoses - main ICD10 |
N85.0 |
Endometrial glandular hyperplasia |
| 41202 |
Diagnoses - main ICD10 |
N85.1 |
Endometrial adenomatous hyperplasia |
| 41202 |
Diagnoses - main ICD10 |
N85.2 |
Hypertrophy of uterus |
| 41204 |
Diagnoses - secondary ICD10 |
N85.0 |
Endometrial glandular hyperplasia |
| 41204 |
Diagnoses - secondary ICD10 |
N85.1 |
Endometrial adenomatous hyperplasia |
| 41204 |
Diagnoses - secondary ICD10 |
N85.2 |
Hypertrophy of uterus |
| 40001 |
Underlying (primary) cause of death: ICD10 |
N85.0 |
Endometrial glandular hyperplasia |
| 40001 |
Underlying (primary) cause of death: ICD10 |
N85.1 |
Endometrial adenomatous hyperplasia |
| 40001 |
Underlying (primary) cause of death: ICD10 |
N85.2 |
Hypertrophy of uterus |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
N85.0 |
Endometrial glandular hyperplasia |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
N85.1 |
Endometrial adenomatous hyperplasia |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
N85.2 |
Hypertrophy of uterus |
| 42040 |
GP clinical event records |
K542000 |
Hypertrophy of uterus unspecified |
| 42040 |
GP clinical event records |
K542100 |
Bulky uterus |
| 42040 |
GP clinical event records |
K542200 |
Enlarged uterus |
| 42040 |
GP clinical event records |
K542.00 |
Hypertrophy of the uterus |
| 42040 |
GP clinical event records |
K542z00 |
Hypertrophy of the uterus NOS |
| 42040 |
GP clinical event records |
K543000 |
Adenomatous endometrial hyperplasia |
| 42040 |
GP clinical event records |
K543100 |
Cystic endometrial hyperplasia |
| 42040 |
GP clinical event records |
K543200 |
Glandular endometrial hyperplasia |
| 42040 |
GP clinical event records |
K543.00 |
Endometrial cystic hyperplasia |
| 42040 |
GP clinical event records |
K543z00 |
Endometrial cystic hyperplasia NOS |
| 42040 |
GP clinical event records |
XaQbW |
Adenomatous endometrial hyperplasia |