Endometriosis

Metadata

Name	Endometriosis (endometriosis)
Category	Genitourinary
Sex
Adult	Yes
UUID	b0b27f08-9f3a-4268-a7f3-e770e75675c8
Definition	The growth of functional endometrial tissue in anatomic sites outside the uterine body. It most often occurs in the pelvic organs.

Ontologies

Disease Ontology (DOID)	DOID_289
GWAS Catalogue	EFO_0001065
MeSH	D004715
SNOMED-CT	396224008
FinnGen	N14_ENDOMETRIOSIS

Key Summary Statistics

Cases from any source

Total	10023
Female (%)	10023 (100%)
Male (%)	0 (0%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	360.82 (348.27,373.37)
Male	0.0 (0.0,0.0)

Incidence stratified by sex

Female	5.84 (5.2,6.48)
Male	0.0 (0.0,0.0)

Incidence stratified by age

Ages 40-44	8.38 (6.56,10.21)
Ages 45-49	6.26 (4.9,7.61)
Ages 50-54	3.45 (2.52,4.38)
Ages 55-59	1.7 (1.11,2.28)
Ages 60-64	1.56 (1.08,2.04)
Ages 65-69	1.62 (1.06,2.19)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	278 (263,294)	199 (189,209)	104 (98,111)
CALIBER	511 (503,520)	373 (365,381)	187 (181,193)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	273(238,312)	195(173,218)	103(90,118)
Low	277(242,316)	208(185,232)	116(102,131)
Medium	249(217,285)	201(179,225)	111(97,127)
High	287(255,323)	206(184,230)	93(80,108)
Most deprived	295(263,329)	181(160,204)	94(80,110)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	290(273,308)	199(188,211)	109(101,116)
Scotland	216(180,258)	197(170,226)	93(76,111)
Wales	257(205,318)	198(164,237)	76(58,99)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153321, Events=259

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.47 (1.07, 2.01)	0.0165
BMI	obese	2.46 (1.81, 3.35)	1.19e-08
BMI	underweight	0 (0, Inf)	0.998
smoking	previous	1.06 (0.81, 1.39)	0.676
smoking	current	0.75 (0.46, 1.22)	0.25
hypertension	yes	0.83 (0.58, 1.19)	0.31

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1402	endometriosis
41202	Diagnoses - main ICD10	N80	Endometriosis
41204	Diagnoses - secondary ICD10	N80	Endometriosis
40001	Underlying (primary) cause of death: ICD10	N80	Endometriosis
40002	Contributory (secondary) causes of death: ICD10	N80	Endometriosis
42040	GP clinical event records	7E0D800	Laparoscopic laser destruction of endometriosis
42040	GP clinical event records	BBL1.11	[M]Stromal endometriosis
42040	GP clinical event records	K500000	Internal endometriosis
42040	GP clinical event records	K500100	Endometriosis of myometrium
42040	GP clinical event records	K500111	Adenomyosis of endometrium
42040	GP clinical event records	K500200	Endometriosis of cervix
42040	GP clinical event records	K500.00	Endometriosis of uterus
42040	GP clinical event records	K500z00	Endometriosis of uterus NOS
42040	GP clinical event records	K501.00	Endometriosis of ovary
42040	GP clinical event records	K501.11	Chocolate cyst of ovary
42040	GP clinical event records	K502.00	Endometriosis of the fallopian tube
42040	GP clinical event records	K503000	Endometriosis of the broad ligament
42040	GP clinical event records	K503100	Endometriosis of the pouch of Douglas
42040	GP clinical event records	K503200	Endometriosis of the parametrium
42040	GP clinical event records	K503300	Endometriosis of the round ligament
42040	GP clinical event records	K503.00	Endometriosis of the pelvic peritoneum
42040	GP clinical event records	K503z00	Endometriosis of the pelvic peritoneum NOS
42040	GP clinical event records	K504000	Endometriosis of the rectovaginal septum
42040	GP clinical event records	K504100	Endometriosis of the vagina
42040	GP clinical event records	K504.00	Endometriosis of the rectovaginal septum and vagina
42040	GP clinical event records	K504z00	Endometriosis of the rectovaginal septum and vagina NOS
42040	GP clinical event records	K505000	Endometriosis of the appendix
42040	GP clinical event records	K505100	Endometriosis of the colon
42040	GP clinical event records	K505200	Endometriosis of the rectum
42040	GP clinical event records	K505.00	Endometriosis of the intestine
42040	GP clinical event records	K505z00	Endometriosis of the intestine NOS
42040	GP clinical event records	K506.00	Endometriosis in scar of skin
42040	GP clinical event records	K50..00	Endometriosis
42040	GP clinical event records	K50..11	Adenomyosis
42040	GP clinical event records	K50y000	Endometriosis of the bladder
42040	GP clinical event records	K50y100	Endometriosis of the lung
42040	GP clinical event records	K50y200	Endometriosis of the umbilicus
42040	GP clinical event records	K50y300	Endometriosis of the vulva
42040	GP clinical event records	K50y.00	Other endometriosis
42040	GP clinical event records	K50yz00	Other endometriosis NOS
42040	GP clinical event records	K50z.00	Endometriosis NOS
42040	GP clinical event records	Kyu9000	[X]Other endometriosis
42040	GP clinical event records	XE0eX	Endometriosis of ovary
42040	GP clinical event records	XaKcc	Laparoscopic laser destruction of endometriosis
42040	GP clinical event records	X408O	Endometriosis of myometrium
42040	GP clinical event records	X408O	Endometriosis of myometrium
42040	GP clinical event records	XE0eW	Endometriosis