Metadata

Name End stage renal disease (ESRD)
Category Genitourinary
Sex
Adult Yes
UUID e9c33ff7-d8ae-4e7d-a888-17ba435ef96b
Definition End-stage renal failure, also known as end-stage renal disease (ESRD), is the final, permanent stage of chronic kidney disease, where kidney function has declined to the point that the kidneys can no longer function on their own.

Ontologies

Disease Ontology (DOID) DOID_783
GWAS Catalogue EFO_0003884
MeSH D007676
SNOMED-CT 46177005
FinnGen N14_DIALYSIS

Key Summary Statistics

Cases from any source

Total 2587
Female (%) 963 (37%)
Male (%) 1624 (63%)

Year first recorded

ESRD year of first event

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Cross-sourced ESRD cases

Incidence & prevalence

Sex and age-stratified incidence and prevalence of ESRD

Baseline prevalence stratified by sex

Female 15.91 (13.23,18.6)
Male 30.94 (26.87,35.01)

Incidence stratified by sex

Female 1.37 (1.07,1.68)
Male 2.53 (2.08,2.99)

Incidence stratified by age

Ages 40-44 0.7 (0.18,1.23)
Ages 45-49 0.67 (0.23,1.11)
Ages 50-54 1.46 (0.86,2.06)
Ages 55-59 1.51 (0.96,2.06)
Ages 60-64 2.54 (1.93,3.15)
Ages 65-69 3.22 (2.43,4.01)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

CALIBER and UKB ESRD prevalence comparison for multiple age groups

Population Ages 40-49 Ages 50-59 Ages 60-69
UK Biobank 18 (14,22) 27 (23,32) 38 (34,43)
CALIBER 18 (17,19) 30 (28,32) 46 (44,48)

Stratified by age and Townsend deprivation status

Deprivation status Ages 40-49 Ages 50-59 Ages 60-69
Least deprived 14(7,25) 19(12,28) 25(18,33)
Low 16(8,28) 12(7,20) 35(27,45)
Medium 10(4,21) 26(18,36) 31(24,40)
High 17(9,28) 39(29,51) 38(29,48)
Most deprived 27(18,40) 40(30,53) 68(55,82)

Stratified by age and country

Country Ages 40-49 Ages 50-59 Ages 60-69
England 17(12,22) 28(23,33) 36(32,41)
Scotland 26(14,44) 29(19,43) 36(26,49)
Wales 16(5,39) 21(10,37) 61(44,83)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153508, Events=407

Factor Level Hazard Ratio P value
BMI overweight 0.96 (0.75, 1.22) 0.716
BMI obese 1.36 (1.06, 1.76) 0.0167
BMI underweight 0 (0, Inf) 0.986
smoking previous 1.37 (1.1, 1.7) 0.00438
smoking current 2.14 (1.6, 2.85) 2.26e-07
hypertension yes 1.88 (1.53, 2.31) 1.47e-09

Risk factors analysis forest plot

Definition

UK Biobank field id Description Code Value
20002 Non-cancer illness code, self-reported 1193 renal failure requiring dialysis
20004 Operation code 1195 Renal/kidney transplant
20004 Operation code 1580 Dialysis access surgery
20004 Operation code 1581 Haemodialysis access/fistula surgery
20004 Operation code 1582 Peritoneal dialysis (capd) access surgery
41202 Diagnoses - main ICD10 N18.5 Chronic kidney disease, stage 5
41202 Diagnoses - main ICD10 T82.4 Mechanical complication of vascular dialysis catheter
41202 Diagnoses - main ICD10 Y60.2 During kidney dialysis or other perfusion
41202 Diagnoses - main ICD10 Y61.2 During kidney dialysis or other perfusion
41202 Diagnoses - main ICD10 Y84.1 Kidney dialysis
41202 Diagnoses - main ICD10 Z49.1 Extracorporeal dialysis
41202 Diagnoses - main ICD10 Z49.2 Other dialysis
41202 Diagnoses - main ICD10 Z99.2 Dependence on renal dialysis
41202 Diagnoses - main ICD10 N16.5 Renal tubulo-interstitial disorders in transplant rejection
41202 Diagnoses - main ICD10 T86.1 Kidney transplant failure and rejection
41202 Diagnoses - main ICD10 Z94.0 Kidney transplant status
41204 Diagnoses - secondary ICD10 N18.5 Chronic kidney disease, stage 5
41204 Diagnoses - secondary ICD10 T82.4 Mechanical complication of vascular dialysis catheter
41204 Diagnoses - secondary ICD10 Y60.2 During kidney dialysis or other perfusion
41204 Diagnoses - secondary ICD10 Y61.2 During kidney dialysis or other perfusion
41204 Diagnoses - secondary ICD10 Y84.1 Kidney dialysis
41204 Diagnoses - secondary ICD10 Z49.1 Extracorporeal dialysis
41204 Diagnoses - secondary ICD10 Z49.2 Other dialysis
41204 Diagnoses - secondary ICD10 Z99.2 Dependence on renal dialysis
41204 Diagnoses - secondary ICD10 N16.5 Renal tubulo-interstitial disorders in transplant rejection
41204 Diagnoses - secondary ICD10 T86.1 Kidney transplant failure and rejection
41204 Diagnoses - secondary ICD10 Z94.0 Kidney transplant status
41200 Operative procedures - main OPCS4 L74.6 Creation of graft fistula for dialysis
41200 Operative procedures - main OPCS4 M01.1 Autotransplantation of kidney
41200 Operative procedures - main OPCS4 M01.2 Allotransplantation of kidney from live donor
41200 Operative procedures - main OPCS4 M01.3 Allotransplantation of kidney from cadaver NEC
41200 Operative procedures - main OPCS4 M01.4 Allotransplantation of kidney from cadaver heart beating
41200 Operative procedures - main OPCS4 M01.5 Allotransplantation of kidney from cadaver heart non-beating
41200 Operative procedures - main OPCS4 M01.8 Other specified transplantation of kidney
41200 Operative procedures - main OPCS4 M01.9 Unspecified transplantation of kidney
41200 Operative procedures - main OPCS4 M02.6 Excision of rejected transplanted kidney
41200 Operative procedures - main OPCS4 M02.7 Excision of transplanted kidney NEC
41200 Operative procedures - main OPCS4 M08.4 Exploration of transplanted kidney
41200 Operative procedures - main OPCS4 M17.2 Pre-transplantation of kidney work-up - recipient
41200 Operative procedures - main OPCS4 M17.4 Post-transplantation of kidney examination - recipient
41200 Operative procedures - main OPCS4 M17.8 Other specified interventions associated with transplantation of kidney
41200 Operative procedures - main OPCS4 M17.9 Unspecified interventions associated with transplantation of kidney
41200 Operative procedures - main OPCS4 X40.1 Renal dialysis
41200 Operative procedures - main OPCS4 X40.2 Peritoneal dialysis NEC
41200 Operative procedures - main OPCS4 X40.3 Haemodialysis NEC
41200 Operative procedures - main OPCS4 X40.5 Automated peritoneal dialysis
41200 Operative procedures - main OPCS4 X40.6 Continuous ambulatory peritoneal dialysis
41200 Operative procedures - main OPCS4 X41.1 Insertion of ambulatory peritoneal dialysis catheter
41200 Operative procedures - main OPCS4 X41.2 Removal of ambulatory peritoneal dialysis catheter
41200 Operative procedures - main OPCS4 X42.1 Insertion of temporary peritoneal dialysis catheter
41210 Operative procedures - secondary OPCS4 L74.6 L74.6
41210 Operative procedures - secondary OPCS4 M01.1 M01.1
41210 Operative procedures - secondary OPCS4 M01.2 M01.2
41210 Operative procedures - secondary OPCS4 M01.3 M01.3
41210 Operative procedures - secondary OPCS4 M01.4 M01.4
41210 Operative procedures - secondary OPCS4 M01.5 M01.5
41210 Operative procedures - secondary OPCS4 M01.8 M01.8
41210 Operative procedures - secondary OPCS4 M01.9 M01.9
41210 Operative procedures - secondary OPCS4 M02.6 M02.6
41210 Operative procedures - secondary OPCS4 M02.7 M02.7
41210 Operative procedures - secondary OPCS4 M08.4 M08.4
41210 Operative procedures - secondary OPCS4 M17.2 M17.2
41210 Operative procedures - secondary OPCS4 M17.4 M17.4
41210 Operative procedures - secondary OPCS4 M17.8 M17.8
41210 Operative procedures - secondary OPCS4 M17.9 M17.9
41210 Operative procedures - secondary OPCS4 X40.1 X40.1
41210 Operative procedures - secondary OPCS4 X40.2 X40.2
41210 Operative procedures - secondary OPCS4 X40.3 X40.3
41210 Operative procedures - secondary OPCS4 X40.5 X40.5
41210 Operative procedures - secondary OPCS4 X40.6 X40.6
41210 Operative procedures - secondary OPCS4 X41.1 X41.1
41210 Operative procedures - secondary OPCS4 X41.2 X41.2
41210 Operative procedures - secondary OPCS4 X42.1 X42.1
40001 Underlying (primary) cause of death: ICD10 N18.5 Chronic kidney disease, stage 5
40001 Underlying (primary) cause of death: ICD10 T82.4 Mechanical complication of vascular dialysis catheter
40001 Underlying (primary) cause of death: ICD10 Y60.2 During kidney dialysis or other perfusion
40001 Underlying (primary) cause of death: ICD10 Y61.2 During kidney dialysis or other perfusion
40001 Underlying (primary) cause of death: ICD10 Y84.1 Kidney dialysis
40001 Underlying (primary) cause of death: ICD10 Z49.1 Extracorporeal dialysis
40001 Underlying (primary) cause of death: ICD10 Z49.2 Other dialysis
40001 Underlying (primary) cause of death: ICD10 Z99.2 Dependence on renal dialysis
40001 Underlying (primary) cause of death: ICD10 N16.5 Renal tubulo-interstitial disorders in transplant rejection
40001 Underlying (primary) cause of death: ICD10 T86.1 Kidney transplant failure and rejection
40001 Underlying (primary) cause of death: ICD10 Z94.0 Kidney transplant status
40002 Contributory (secondary) causes of death: ICD10 N18.5 Chronic kidney disease, stage 5
40002 Contributory (secondary) causes of death: ICD10 T82.4 Mechanical complication of vascular dialysis catheter
40002 Contributory (secondary) causes of death: ICD10 Y60.2 During kidney dialysis or other perfusion
40002 Contributory (secondary) causes of death: ICD10 Y61.2 During kidney dialysis or other perfusion
40002 Contributory (secondary) causes of death: ICD10 Y84.1 Kidney dialysis
40002 Contributory (secondary) causes of death: ICD10 Z49.1 Extracorporeal dialysis
40002 Contributory (secondary) causes of death: ICD10 Z49.2 Other dialysis
40002 Contributory (secondary) causes of death: ICD10 Z99.2 Dependence on renal dialysis
40002 Contributory (secondary) causes of death: ICD10 N16.5 Renal tubulo-interstitial disorders in transplant rejection
40002 Contributory (secondary) causes of death: ICD10 T86.1 Kidney transplant failure and rejection
40002 Contributory (secondary) causes of death: ICD10 Z94.0 Kidney transplant status
42040 GP clinical event records 14S2.00 H/O: kidney recipient
42040 GP clinical event records 14V2.00 H/O: renal dialysis
42040 GP clinical event records 14V2.11 H/O: kidney dialysis
42040 GP clinical event records 1Z14.00 Chronic kidney disease stage 5
42040 GP clinical event records 1Z1K.00 Chronic kidney disease stage 5 with proteinuria
42040 GP clinical event records 1Z1L.00 Chronic kidney disease stage 5 without proteinuria
42040 GP clinical event records 1Z1L.11 CKD stage 5 without proteinuria
42040 GP clinical event records 4I29.00 Peritoneal dialysis sample
42040 GP clinical event records 4N0..00 Dialysis fluid urea level
42040 GP clinical event records 4N2..00 Dialysis fluid glucose level
42040 GP clinical event records 7B00100 Transplantation of kidney from live donor
42040 GP clinical event records 7B00111 Allotransplantation of kidney from live donor
42040 GP clinical event records 7B00200 Transplantation of kidney from cadaver
42040 GP clinical event records 7B00211 Allotransplantation of kidney from cadaver
42040 GP clinical event records 7B00212 Cadaveric renal transplant
42040 GP clinical event records 7B00300 Allotransplantation of kidney from cadaver, heart-beating
42040 GP clinical event records 7B00400 Allotransplantation kidney from cadaver, heart non-beating
42040 GP clinical event records 7B00500 Allotransplantation of kidney from cadaver NEC
42040 GP clinical event records 7B00.00 Transplantation of kidney
42040 GP clinical event records 7B00y00 Other specified transplantation of kidney
42040 GP clinical event records 7B00z00 Transplantation of kidney NOS
42040 GP clinical event records 7B01511 Excision of rejected transplanted kidney
42040 GP clinical event records 7B06300 Exploration of renal transplant
42040 GP clinical event records 7B0F300 Post-transplantation of kidney examination, recipient
42040 GP clinical event records 7B0F.00 Interventions associated with transplantation of kidney
42040 GP clinical event records 7B0Fy00 OS interventions associated with transplantation of kidney
42040 GP clinical event records 7B0Fz00 Interventions associated with transplantation of kidney NOS
42040 GP clinical event records 7L1A000 Renal dialysis
42040 GP clinical event records 7L1A011 Thomas intravascular shunt for dialysis
42040 GP clinical event records 7L1A100 Peritoneal dialysis
42040 GP clinical event records 7L1A200 Haemodialysis NEC
42040 GP clinical event records 7L1A400 Automated peritoneal dialysis
42040 GP clinical event records 7L1A500 Continuous ambulatory peritoneal dialysis
42040 GP clinical event records 7L1A600 Peritoneal dialysis NEC
42040 GP clinical event records 7L1A.11 Dialysis for renal failure
42040 GP clinical event records 7L1B000 Insertion of ambulatory peritoneal dialysis catheter
42040 GP clinical event records 7L1B100 Removal of ambulatory peritoneal dialysis catheter
42040 GP clinical event records 7L1B200 Flushing of peritoneal dialysis catheter
42040 GP clinical event records 7L1B.11 Placement ambulatory dialysis apparatus - compens renal fail
42040 GP clinical event records 7L1C000 Insertion of temporary peritoneal dialysis catheter
42040 GP clinical event records 8882.00 Intestinal dialysis
42040 GP clinical event records G72C.00 Ruptured aneurysm of dialysis vascular access
42040 GP clinical event records G72D000 Aneurysm of superficialised artery of dialysis AV fistula
42040 GP clinical event records G72D100 Aneurysm of needle site of dialysis arteriovenous fistula
42040 GP clinical event records G72D200 Aneurysm of anastomotic site of dialysis AV fistula
42040 GP clinical event records G72D.00 Aneurysm of dialysis arteriovenous fistula
42040 GP clinical event records Gy10.00 Stenosis of dialysis arteriovenous graft
42040 GP clinical event records Gy1..00 Stenosis of dialysis vascular access
42040 GP clinical event records Gy21.00 Thrombosis of dialysis arteriovenous fistula
42040 GP clinical event records Gy2..00 Thrombosis of dialysis vascular access
42040 GP clinical event records Gy30.00 Occlusion of dialysis arteriovenous graft
42040 GP clinical event records Gy31.00 Occlusion of dialysis arteriovenous fistula
42040 GP clinical event records Gy3..00 Occlusion of dialysis vascular access
42040 GP clinical event records Gy40.00 Infection of dialysis arteriovenous graft
42040 GP clinical event records Gy41.00 Infection of dialysis arteriovenous fistula
42040 GP clinical event records Gy4..00 Infection of dialysis vascular access
42040 GP clinical event records Gy51.00 Haemorrhage of dialysis arteriovenous fistula
42040 GP clinical event records Gy5..00 Haemorrhage of dialysis vascular access
42040 GP clinical event records Gy60.00 Rupture of dialysis arteriovenous graft
42040 GP clinical event records K050.00 End stage renal failure
42040 GP clinical event records K05..12 End stage renal failure
42040 GP clinical event records K0B5.00 Renal tubulo-interstitial disordrs in transplant rejectn
42040 GP clinical event records K0D..00 End-stage renal disease
42040 GP clinical event records Kyu1C00 [X]Renal tubulo-interstitial disorders/transplant rejection
42040 GP clinical event records SP01500 Mechanical complication of dialysis catheter
42040 GP clinical event records SP05613 [X] Peritoneal dialysis associated peritonitis
42040 GP clinical event records SP06B00 Continuous ambulatory peritoneal dialysis associated perit
42040 GP clinical event records SP07G00 Stenosis of arteriovenous dialysis fistula
42040 GP clinical event records SP08300 Kidney transplant failure and rejection
42040 GP clinical event records SP08D00 Acute-on-chronic rejection of renal transplant
42040 GP clinical event records SP08E00 Acute rejection of renal transplant - grade I
42040 GP clinical event records SP08F00 Acute rejection of renal transplant - grade II
42040 GP clinical event records SP08G00 Acute rejection of renal transplant - grade III
42040 GP clinical event records SP08H00 Acute rejection of renal transplant
42040 GP clinical event records SP08J00 Chronic rejection of renal transplant
42040 GP clinical event records SP08N00 Unexplained episode of renal transplant dysfunction
42040 GP clinical event records SP08P00 Stenosis of vein of transplanted kidney
42040 GP clinical event records SP08R00 Renal transplant rejection
42040 GP clinical event records SP08T00 Urological complication of renal transplant
42040 GP clinical event records SP08V00 Very mild acute rejection of renal transplant
42040 GP clinical event records SP08W00 Vascular complication of renal transplant
42040 GP clinical event records SP0E.00 Disorders associated with peritoneal dialysis
42040 GP clinical event records SP0F.00 Haemodialysis first use syndrome
42040 GP clinical event records SP0G.00 Anaphylactoid reaction due to haemodialysis
42040 GP clinical event records TA02000 Accid cut,puncture,perf,h’ge - kidney dialysis
42040 GP clinical event records TA22000 Failure of sterile precautions during kidney dialysis
42040 GP clinical event records TB00100 Kidney transplant with complication, without blame
42040 GP clinical event records TB00111 Renal transplant with complication, without blame
42040 GP clinical event records TB11.00 Kidney dialysis with complication, without blame
42040 GP clinical event records TB11.11 Renal dialysis with complication, without blame
42040 GP clinical event records Z1A1.00 Peritoneal dialysis training
42040 GP clinical event records Z1A2.00 Haemodialysis training
42040 GP clinical event records Z1A..00 Dialysis training
42040 GP clinical event records Z919100 Priming haemodialysis lines
42040 GP clinical event records Z919200 Washing back through haemodialysis lines
42040 GP clinical event records Z919300 Reversing haemodialysis lines
42040 GP clinical event records Z919.00 Care of haemodialysis equipment
42040 GP clinical event records Z91A.00 Peritoneal dialysis bag procedure
42040 GP clinical event records ZV42000 [V]Kidney transplanted
42040 GP clinical event records ZV45100 [V]Renal dialysis status
42040 GP clinical event records ZV56000 [V]Aftercare involving extracorporeal dialysis
42040 GP clinical event records ZV56011 [V]Aftercare involving renal dialysis NOS
42040 GP clinical event records ZV56y00 [V]Other specified aftercare involving intermittent dialysis
42040 GP clinical event records ZV56y11 [V]Aftercare involving peritoneal dialysis
42040 GP clinical event records ZV56.00 [V]Aftercare involving intermittent dialysis
42040 GP clinical event records ZV56z00 [V]Unspecified aftercare involving intermittent dialysis
42040 GP clinical event records ZVu3G00 [X]Other dialysis
42040 GP clinical event records XaMMt Peritoneal dialysis NEC
42040 GP clinical event records XaZcX Aneurysm of needle site of dialysis arteriovenous fistula
42040 GP clinical event records X30MU Acute rejection of renal transplant - grade I
42040 GP clinical event records XE0Fv Transplant nephrectomy
42040 GP clinical event records XaMKM Allotransplantation of kidney from cadaver NEC
42040 GP clinical event records X30MT Acute rejection of renal transplant
42040 GP clinical event records Xaa7K Rupture of dialysis arteriovenous graft
42040 GP clinical event records XaZlu Stenosis of dialysis vascular access
42040 GP clinical event records XE0Jf Compensation for renal failure
42040 GP clinical event records XaM1p Allotransplantation of kidney from cadaver, heart non-beating
42040 GP clinical event records XaM1o Allotransplantation of kidney from cadaver, heart-beating
42040 GP clinical event records XaLHK Chronic kidney disease stage 5
42040 GP clinical event records Xaa5f Thrombosis of dialysis arteriovenous fistula
42040 GP clinical event records X40c3 Continuous ambulatory peritoneal dialysis
42040 GP clinical event records Xaa5W Stenosis of dialysis arteriovenous graft
42040 GP clinical event records XaZcQ Aneurysm of superficialised artery of dialysis arteriovenous fistula
42040 GP clinical event records XaREO Continuous ambulatory peritoneal dialysis associated peritonitis
42040 GP clinical event records Xaa5U Haemorrhage of dialysis vascular access
42040 GP clinical event records Xaa5h Occlusion of dialysis arteriovenous graft
42040 GP clinical event records Xaa5S Occlusion of dialysis vascular access
42040 GP clinical event records X30MV Acute rejection of renal transplant - grade II
42040 GP clinical event records XaM4l Post-transplantation of kidney examination, recipient
42040 GP clinical event records XE0df Chronic renal failure
42040 GP clinical event records XaZe7 Stenosis of vein of transplanted kidney
42040 GP clinical event records XaZYx Vascular complication of renal transplant
42040 GP clinical event records XaM2A Automated peritoneal dialysis
42040 GP clinical event records X30M7 Disorders associated with peritoneal dialysis
42040 GP clinical event records Xaa6n Infection of dialysis arteriovenous graft
42040 GP clinical event records XaZlv Thrombosis of dialysis vascular access
42040 GP clinical event records XE0Jg Renal dialysis
42040 GP clinical event records XaZcU Aneurysm of dialysis arteriovenous fistula
42040 GP clinical event records Xaa5i Occlusion of dialysis arteriovenous fistula
42040 GP clinical event records Xaa6o Infection of dialysis arteriovenous fistula
42040 GP clinical event records X30MX Chronic rejection of renal transplant
42040 GP clinical event records XaJkg Dialysis fluid glucose level
42040 GP clinical event records XaM4g Interventions associated with transplantation of kidney NOS
42040 GP clinical event records X30MS Very mild acute rejection of renal transplant
42040 GP clinical event records XaO41 Chronic kidney disease stage 5 with proteinuria
42040 GP clinical event records X30MP Renal transplant rejection
42040 GP clinical event records XaZcd Aneurysm of anastomotic site of dialysis arteriovenous fistula
42040 GP clinical event records XaKyg Stenosis of arteriovenous dialysis fistula
42040 GP clinical event records Xa0HK Unexplained episode of renal transplant dysfunction
42040 GP clinical event records XaO42 Chronic kidney disease stage 5 without proteinuria
42040 GP clinical event records XaM4e Interventions associated with transplantation of kidney
42040 GP clinical event records Xaa7I Haemorrhage of dialysis arteriovenous fistula
42040 GP clinical event records XaJke Dialysis fluid urea level
42040 GP clinical event records X30J0 End stage renal failure
42040 GP clinical event records XaZWa Urological complication of renal transplant
42040 GP clinical event records XaM4f Other specified interventions associated with transplantation of kidney
42040 GP clinical event records Xaa5T Infection of dialysis vascular access
42040 GP clinical event records XaZmp Anaphylactoid reaction due to haemodialysis
42040 GP clinical event records SyuKH [X]Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts
42040 GP clinical event records X30Mb Acute-on-chronic rejection of renal transplant
42040 GP clinical event records XaZc8 Ruptured aneurysm of dialysis vascular access
42040 GP clinical event records X30MW Acute rejection of renal transplant - grade III