| Name |
Essential tremor (essential_tremor) |
| Category |
Neurological |
| Sex |
|
| Adult |
Yes |
| UUID |
80ffc4d6-b990-48d7-af3c-425b7d1a580a |
| Definition |
Essential tremor is a nervous system (neurological) disorder that causes involuntary and rhythmic shaking. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
1757 |
| Female (%) |
854 (49%) |
| Male (%) |
903 (51%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
15.8 (13.12,18.47) |
| Male |
18.62 (15.46,21.78) |
Incidence stratified by sex
| Female |
3.05 (2.59,3.5) |
| Male |
4.28 (3.69,4.87) |
Incidence stratified by age
| Ages 40-44 |
1.11 (0.45,1.76) |
| Ages 45-49 |
1.41 (0.78,2.04) |
| Ages 50-54 |
1.46 (0.86,2.05) |
| Ages 55-59 |
2.71 (1.97,3.44) |
| Ages 60-64 |
5.74 (4.82,6.66) |
| Ages 65-69 |
6.15 (5.06,7.24) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
16 (13,21) |
24 (20,28) |
52 (47,57) |
| CALIBER |
12 (11,13) |
19 (17,20) |
44 (42,46) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
10(4,20) |
25(17,35) |
44(35,55) |
| Low |
23(13,37) |
19(12,29) |
51(42,62) |
| Medium |
13(6,24) |
22(15,32) |
52(42,64) |
| High |
22(13,34) |
26(18,36) |
47(37,59) |
| Most deprived |
15(9,25) |
27(19,38) |
68(56,82) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
16(12,21) |
26(22,31) |
55(50,61) |
| Scotland |
17(7,33) |
7(2,14) |
30(20,42) |
| Wales |
16(5,39) |
29(16,49) |
53(37,73) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153420, Events=132
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.98 (0.66, 1.47) |
0.928 |
| BMI |
obese |
1.08 (0.69, 1.7) |
0.735 |
| BMI |
underweight |
0 (0, Inf) |
0.992 |
| smoking |
previous |
1.16 (0.78, 1.73) |
0.462 |
| smoking |
current |
2.27 (1.45, 3.57) |
0.000355 |
| hypertension |
yes |
1.19 (0.76, 1.85) |
0.449 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1525 |
benign / essential tremor |
| 41202 |
Diagnoses - main ICD10 |
G25.0 |
Essential tremor |
| 41204 |
Diagnoses - secondary ICD10 |
G25.0 |
Essential tremor |
| 40001 |
Underlying (primary) cause of death: ICD10 |
G25.0 |
Essential tremor |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
G25.0 |
Essential tremor |
| 42040 |
GP clinical event records |
F131000 |
Benign essential tremor |
| 42040 |
GP clinical event records |
F131100 |
Familial tremor |