Metadata

Name Eye infections (eye)
Category Infections
Sex
Adult Yes
UUID 67c753d2-7a78-4e90-b3c2-81907b80c98e
Definition Infection, moderate to severe, caused by bacteria, fungi, or viruses, which occurs either on the external surface of the eye or intraocularly with probable inflammation, visual impairment, or blindness.

Ontologies

GWAS Catalogue MONDO_0043885
MeSH D015817
SNOMED-CT 128351009

Key Summary Statistics

Cases from any source

Total 1864
Female (%) 973 (52%)
Male (%) 891 (48%)

Year first recorded

eye year of first event

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Cross-sourced eye cases

Incidence & prevalence

Sex and age-stratified incidence and prevalence of eye

Baseline prevalence stratified by sex

Female 16.62 (13.88,19.36)
Male 14.98 (12.14,17.82)

Incidence stratified by sex

Female 1.06 (0.79,1.32)
Male 1.35 (1.02,1.68)

Incidence stratified by age

Ages 40-44 0.6 (0.12,1.09)
Ages 45-49 0.67 (0.23,1.1)
Ages 50-54 1.14 (0.61,1.67)
Ages 55-59 0.99 (0.54,1.43)
Ages 60-64 1.5 (1.03,1.97)
Ages 65-69 1.66 (1.09,2.23)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

CALIBER and UKB eye prevalence comparison for multiple age groups

Population Ages 40-49 Ages 50-59 Ages 60-69
UK Biobank 9 (7,13) 14 (11,17) 17 (15,20)
CALIBER 8 (7,8) 10 (9,11) 15 (14,16)

Stratified by age and Townsend deprivation status

Deprivation status Ages 40-49 Ages 50-59 Ages 60-69
Least deprived 6(2,15) 10(5,18) 16(11,23)
Low 4(1,12) 11(6,19) 16(11,23)
Medium 11(5,22) 11(6,18) 16(10,22)
High 12(6,21) 16(10,24) 18(13,26)
Most deprived 12(6,20) 21(14,30) 20(14,28)

Stratified by age and country

Country Ages 40-49 Ages 50-59 Ages 60-69
England 9(6,13) 15(11,18) 17(14,20)
Scotland 9(2,22) 14(7,24) 15(9,24)
Wales 16(5,39) 7(2,18) 21(12,35)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153969, Events=129

Factor Level Hazard Ratio P value
BMI overweight 1.18 (0.74, 1.86) 0.489
BMI obese 1.91 (1.2, 3.06) 0.00685
BMI underweight 0 (0, Inf) 0.995
smoking previous 1.29 (0.88, 1.87) 0.189
smoking current 1.41 (0.81, 2.45) 0.23
hypertension yes 1.93 (1.34, 2.77) 0.000403

Risk factors analysis forest plot

Definition

UK Biobank field id Description Code Value
20002 Non-cancer illness code, self-reported 1274 eye infection
41202 Diagnoses - main ICD10 A18.5 Tuberculosis of eye
41202 Diagnoses - main ICD10 A21.1 Oculoglandular tularaemia
41202 Diagnoses - main ICD10 A54.3 Gonococcal infection of eye
41202 Diagnoses - main ICD10 A71 Trachoma
41202 Diagnoses - main ICD10 A74.0 Chlamydial conjunctivitis
41202 Diagnoses - main ICD10 B00.5 Herpesviral ocular disease
41202 Diagnoses - main ICD10 B02.3 Zoster ocular disease
41202 Diagnoses - main ICD10 B30 Viral conjunctivitis
41202 Diagnoses - main ICD10 B58.0 Toxoplasma oculopathy
41202 Diagnoses - main ICD10 B69.1 Cysticercosis of eye
41202 Diagnoses - main ICD10 B87.2 Ocular myiasis
41202 Diagnoses - main ICD10 B94.0 Sequelae of trachoma
41202 Diagnoses - main ICD10 H00.0 Hordeolum and other deep inflammation of eyelid
41202 Diagnoses - main ICD10 H10 Conjunctivitis
41202 Diagnoses - main ICD10 H13.1 Conjunctivitis in infectious and parasitic diseases classified elsewhere
41202 Diagnoses - main ICD10 H19.1 Herpesviral keratitis and keratoconjunctivitis
41202 Diagnoses - main ICD10 H19.2 Keratitis and keratoconjunctivitis in other infectious and parasitic diseases classified elsewhere
41202 Diagnoses - main ICD10 P39.1 Neonatal conjunctivitis and dacryocystitis
41204 Diagnoses - secondary ICD10 A18.5 Tuberculosis of eye
41204 Diagnoses - secondary ICD10 A21.1 Oculoglandular tularaemia
41204 Diagnoses - secondary ICD10 A54.3 Gonococcal infection of eye
41204 Diagnoses - secondary ICD10 A71 Trachoma
41204 Diagnoses - secondary ICD10 A74.0 Chlamydial conjunctivitis
41204 Diagnoses - secondary ICD10 B00.5 Herpesviral ocular disease
41204 Diagnoses - secondary ICD10 B02.3 Zoster ocular disease
41204 Diagnoses - secondary ICD10 B30 Viral conjunctivitis
41204 Diagnoses - secondary ICD10 B58.0 Toxoplasma oculopathy
41204 Diagnoses - secondary ICD10 B69.1 Cysticercosis of eye
41204 Diagnoses - secondary ICD10 B87.2 Ocular myiasis
41204 Diagnoses - secondary ICD10 B94.0 Sequelae of trachoma
41204 Diagnoses - secondary ICD10 H00.0 Hordeolum and other deep inflammation of eyelid
41204 Diagnoses - secondary ICD10 H10 Conjunctivitis
41204 Diagnoses - secondary ICD10 H13.1 Conjunctivitis in infectious and parasitic diseases classified elsewhere
41204 Diagnoses - secondary ICD10 H19.1 Herpesviral keratitis and keratoconjunctivitis
41204 Diagnoses - secondary ICD10 H19.2 Keratitis and keratoconjunctivitis in other infectious and parasitic diseases classified elsewhere
41204 Diagnoses - secondary ICD10 P39.1 Neonatal conjunctivitis and dacryocystitis
40001 Underlying (primary) cause of death: ICD10 A18.5 Tuberculosis of eye
40001 Underlying (primary) cause of death: ICD10 A21.1 Oculoglandular tularaemia
40001 Underlying (primary) cause of death: ICD10 A54.3 Gonococcal infection of eye
40001 Underlying (primary) cause of death: ICD10 A71 Trachoma
40001 Underlying (primary) cause of death: ICD10 A74.0 Chlamydial conjunctivitis
40001 Underlying (primary) cause of death: ICD10 B00.5 Herpesviral ocular disease
40001 Underlying (primary) cause of death: ICD10 B02.3 Zoster ocular disease
40001 Underlying (primary) cause of death: ICD10 B30 Viral conjunctivitis
40001 Underlying (primary) cause of death: ICD10 B58.0 Toxoplasma oculopathy
40001 Underlying (primary) cause of death: ICD10 B69.1 Cysticercosis of eye
40001 Underlying (primary) cause of death: ICD10 B87.2 Ocular myiasis
40001 Underlying (primary) cause of death: ICD10 B94.0 Sequelae of trachoma
40001 Underlying (primary) cause of death: ICD10 H00.0 Hordeolum and other deep inflammation of eyelid
40001 Underlying (primary) cause of death: ICD10 H10 Conjunctivitis
40001 Underlying (primary) cause of death: ICD10 H13.1 Conjunctivitis in infectious and parasitic diseases classified elsewhere
40001 Underlying (primary) cause of death: ICD10 H19.1 Herpesviral keratitis and keratoconjunctivitis
40001 Underlying (primary) cause of death: ICD10 H19.2 Keratitis and keratoconjunctivitis in other infectious and parasitic diseases classified elsewhere
40001 Underlying (primary) cause of death: ICD10 P39.1 Neonatal conjunctivitis and dacryocystitis
40002 Contributory (secondary) causes of death: ICD10 A18.5 Tuberculosis of eye
40002 Contributory (secondary) causes of death: ICD10 A21.1 Oculoglandular tularaemia
40002 Contributory (secondary) causes of death: ICD10 A54.3 Gonococcal infection of eye
40002 Contributory (secondary) causes of death: ICD10 A71 Trachoma
40002 Contributory (secondary) causes of death: ICD10 A74.0 Chlamydial conjunctivitis
40002 Contributory (secondary) causes of death: ICD10 B00.5 Herpesviral ocular disease
40002 Contributory (secondary) causes of death: ICD10 B02.3 Zoster ocular disease
40002 Contributory (secondary) causes of death: ICD10 B30 Viral conjunctivitis
40002 Contributory (secondary) causes of death: ICD10 B58.0 Toxoplasma oculopathy
40002 Contributory (secondary) causes of death: ICD10 B69.1 Cysticercosis of eye
40002 Contributory (secondary) causes of death: ICD10 B87.2 Ocular myiasis
40002 Contributory (secondary) causes of death: ICD10 B94.0 Sequelae of trachoma
40002 Contributory (secondary) causes of death: ICD10 H00.0 Hordeolum and other deep inflammation of eyelid
40002 Contributory (secondary) causes of death: ICD10 H10 Conjunctivitis
40002 Contributory (secondary) causes of death: ICD10 H13.1 Conjunctivitis in infectious and parasitic diseases classified elsewhere
40002 Contributory (secondary) causes of death: ICD10 H19.1 Herpesviral keratitis and keratoconjunctivitis
40002 Contributory (secondary) causes of death: ICD10 H19.2 Keratitis and keratoconjunctivitis in other infectious and parasitic diseases classified elsewhere
40002 Contributory (secondary) causes of death: ICD10 P39.1 Neonatal conjunctivitis and dacryocystitis