| Name |
Fatty Liver (fatty_liver) |
| Category |
Digestive |
| Sex |
|
| Adult |
Yes |
| UUID |
8053b4c5-e315-40b2-a54c-9c6d1f14defe |
| Definition |
Lipid infiltration of the hepatic parenchymal cells that is due to alcohol abuse. The fatty changes in the alcoholic fatty liver may be reversible, depending on the amounts of triglycerides accumulated. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
8070 |
| Female (%) |
3974 (49%) |
| Male (%) |
4096 (51%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
18.04 (15.18,20.89) |
| Male |
38.78 (34.22,43.34) |
Incidence stratified by sex
| Female |
11.06 (10.2,11.93) |
| Male |
15.69 (14.56,16.82) |
Incidence stratified by age
| Ages 40-44 |
10.6 (8.57,12.63) |
| Ages 45-49 |
11.02 (9.25,12.8) |
| Ages 50-54 |
13.82 (11.98,15.66) |
| Ages 55-59 |
15.27 (13.52,17.02) |
| Ages 60-64 |
13.29 (11.88,14.69) |
| Ages 65-69 |
13.17 (11.57,14.77) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
87 (78,96) |
110 (103,119) |
107 (100,114) |
| CALIBER |
52 (50,54) |
79 (76,81) |
77 (74,80) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
72(53,95) |
64(51,80) |
77(65,90) |
| Low |
69(51,92) |
86(70,104) |
100(87,115) |
| Medium |
71(53,94) |
95(79,114) |
95(82,110) |
| High |
91(72,114) |
131(112,153) |
121(105,139) |
| Most deprived |
116(96,139) |
169(148,193) |
151(132,171) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
97(87,108) |
128(118,138) |
121(113,129) |
| Scotland |
54(35,79) |
57(42,76) |
56(43,72) |
| Wales |
24(10,49) |
31(17,50) |
39(26,57) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153646, Events=402
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
1.07 (0.82, 1.39) |
0.637 |
| BMI |
obese |
2.13 (1.65, 2.77) |
1.06e-08 |
| BMI |
underweight |
0 (0, Inf) |
0.986 |
| smoking |
previous |
1.48 (1.19, 1.85) |
0.000498 |
| smoking |
current |
2.47 (1.87, 3.26) |
1.43e-10 |
| hypertension |
yes |
2.21 (1.8, 2.72) |
5.76e-14 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 41202 |
Diagnoses - main ICD10 |
K70.0 |
Alcoholic fatty liver |
| 41202 |
Diagnoses - main ICD10 |
K75.8 |
Other specified inflammatory liver diseases |
| 41202 |
Diagnoses - main ICD10 |
K76.0 |
Fatty (change of) liver, not elsewhere classified |
| 41204 |
Diagnoses - secondary ICD10 |
K70.0 |
Alcoholic fatty liver |
| 41204 |
Diagnoses - secondary ICD10 |
K75.8 |
Other specified inflammatory liver diseases |
| 41204 |
Diagnoses - secondary ICD10 |
K76.0 |
Fatty (change of) liver, not elsewhere classified |
| 40001 |
Underlying (primary) cause of death: ICD10 |
K70.0 |
Alcoholic fatty liver |
| 40001 |
Underlying (primary) cause of death: ICD10 |
K75.8 |
Other specified inflammatory liver diseases |
| 40001 |
Underlying (primary) cause of death: ICD10 |
K76.0 |
Fatty (change of) liver, not elsewhere classified |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
K70.0 |
Alcoholic fatty liver |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
K75.8 |
Other specified inflammatory liver diseases |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
K76.0 |
Fatty (change of) liver, not elsewhere classified |
| 42040 |
GP clinical event records |
J610.00 |
Alcoholic fatty liver |
| 42040 |
GP clinical event records |
J61y700 |
Steatosis of liver |
| 42040 |
GP clinical event records |
J61y800 |
Nonalcoholic steatohepatitis |
| 42040 |
GP clinical event records |
J61y900 |
Fatty change of liver |
| 42040 |
GP clinical event records |
J61y911 |
Fatty liver |
| 42040 |
GP clinical event records |
XaQIT |
Nonalcoholic steatohepatitis |
| 42040 |
GP clinical event records |
X307v |
Fatty change of liver |