Female genital prolapse

Metadata

Name	Female genital prolapse (female_genital_prolapse)
Category	Genitourinary
Sex
Adult	Yes
UUID	6ccec093-4704-41d2-b7f5-c0b1a66133e5
Definition	A female reproductive system disease that is characteried by the descent of one or more of the pelvic structures (bladder, uterus, vagina) from the normal anatomic location toward or through the vaginal opening.

Ontologies

Disease Ontology (DOID)	DOID_1284
GWAS Catalogue	EFO_1001864
MeSH	D014596
SNOMED-CT	73998008
FinnGen	N14_FEMGENPROL

Key Summary Statistics

Cases from any source

Total	24004
Female (%)	24004 (100%)
Male (%)	0 (0%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	616.26 (600.08,632.44)
Male	0.0 (0.0,0.0)

Incidence stratified by sex

Female	54.02 (52.03,56.01)
Male	0.0 (0.0,0.0)

Incidence stratified by age

Ages 40-44	16.01 (13.5,18.51)
Ages 45-49	19.95 (17.54,22.36)
Ages 50-54	24.69 (22.2,27.18)
Ages 55-59	26.63 (24.27,28.99)
Ages 60-64	34.38 (32.06,36.7)
Ages 65-69	37.43 (34.66,40.21)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	212 (198,225)	369 (355,383)	631 (616,647)
CALIBER	400 (392,407)	736 (725,748)	1221 (1205,

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	242(209,278)	389(358,422)	626(593,662)
Low	218(187,253)	383(352,416)	650(616,685)
Medium	215(185,249)	362(333,394)	625(591,660)
High	189(163,218)	369(339,400)	626(591,663)
Most deprived	202(176,231)	339(310,370)	626(589,665)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	214(200,230)	376(361,392)	633(616,651)
Scotland	152(122,188)	274(243,308)	562(521,606)
Wales	284(229,348)	457(404,514)	728(667,792)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153321, Events=259

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.47 (1.07, 2.01)	0.0165
BMI	obese	2.46 (1.81, 3.35)	1.19e-08
BMI	underweight	0 (0, Inf)	0.998
smoking	previous	1.06 (0.81, 1.39)	0.676
smoking	current	0.75 (0.46, 1.22)	0.25
hypertension	yes	0.83 (0.58, 1.19)	0.31

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1353	vaginal prolapse/uterine prolapse
41202	Diagnoses - main ICD10	N81	Female genital prolapse
41204	Diagnoses - secondary ICD10	N81	Female genital prolapse
40001	Underlying (primary) cause of death: ICD10	N81	Female genital prolapse
40002	Contributory (secondary) causes of death: ICD10	N81	Female genital prolapse
42040	GP clinical event records	1594.00	H/O: genital prolapse
42040	GP clinical event records	7D17000	Ant and post colporrhaphy and amputation of cervix uteri
42040	GP clinical event records	7D17100	Anterior colporrhaphy and amputation of cervix uteri NEC
42040	GP clinical event records	7D17111	Fothergill anterior colporrhaphy and amputation of cervix
42040	GP clinical event records	7D17200	Posterior colporrhaphy and amputation of cervix uteri NEC
42040	GP clinical event records	7D17.00	Repair of vaginal prolapse and amputation of cervix uteri
42040	GP clinical event records	7D17.11	Colporrhaphy and amputation of cervix uteri
42040	GP clinical event records	7D17y00	Repair of vaginal prolapse & amputation of cervix uteri OS
42040	GP clinical event records	7D17z00	Repair of vaginal prolapse & amputation of cervix uteri NOS
42040	GP clinical event records	7D17z11	Manchester repair
42040	GP clinical event records	7D18000	Anterior and posterior colporrhaphy NEC
42040	GP clinical event records	7D18011	Anterior and posterior repair
42040	GP clinical event records	7D18100	Anterior colporrhaphy NEC
42040	GP clinical event records	7D18111	Anterior repair
42040	GP clinical event records	7D18200	Posterior colporrhaphy NEC
42040	GP clinical event records	7D18211	Posterior repair
42040	GP clinical event records	7D18300	Repair of enterocele NEC
42040	GP clinical event records	7D18311	McCall repair of enterocele
42040	GP clinical event records	7D18312	Moschowitz repair of enterocele
42040	GP clinical event records	7D18400	Colporrhaphy NEC
42040	GP clinical event records	7D18500	Anterior mesh vaginal repair
42040	GP clinical event records	7D18600	Paravaginal repair
42040	GP clinical event records	7D18700	Anterior colporrhaphy with mesh reinforcement
42040	GP clinical event records	7D18.00	Other repair of vaginal prolapse
42040	GP clinical event records	7D18.11	Colporrhaphy
42040	GP clinical event records	7D18800	Posterior colporrhaphy with mesh reinforcement
42040	GP clinical event records	7D18y00	Other specified other repair of vaginal prolapse
42040	GP clinical event records	7D18z00	Other repair of vaginal prolapse NOS
42040	GP clinical event records	7D19000	Repair vaginal vault combined abdominal & vaginal approach
42040	GP clinical event records	7D19100	Repair of vault of vagina using abdominal approach NEC
42040	GP clinical event records	7D19200	Repair of vault of vagina using vaginal approach NEC
42040	GP clinical event records	7D19300	Sacrocolpopexy
42040	GP clinical event records	7D19400	Suspension of vagina NEC
42040	GP clinical event records	7D19500	Sacrospinous fixation of vaginal vault
42040	GP clinical event records	7D19600	Repair of vault of vagina with mesh using abdominal approach
42040	GP clinical event records	7D19700	Repair of vault of vagina with mesh using vaginal approach
42040	GP clinical event records	7D19.00	Repair of vault of vagina
42040	GP clinical event records	7D19y00	Other specified repair of vault of vagina
42040	GP clinical event records	7D19z00	Repair of vault of vagina NOS
42040	GP clinical event records	7D1A411	Colpoperineorrhaphy
42040	GP clinical event records	7D1B000	Insertion of Hodge pessary into vagina
42040	GP clinical event records	7D1B100	Insertion of ring into vagina
42040	GP clinical event records	7D1B200	Removal of supporting pessary from vagina
42040	GP clinical event records	7D1B300	Change of vaginal pessary
42040	GP clinical event records	7D1B400	Removal of ring pessary from vagina
42040	GP clinical event records	7D1B500	Renewal of supporting pessary in vagina
42040	GP clinical event records	7D1B600	Insertion of ring pessary into vagina
42040	GP clinical event records	7D1B.00	Introduction of supporting pessary into vagina
42040	GP clinical event records	7D1By00	Introduction of supporting pessary into vagina OS
42040	GP clinical event records	7D1Bz00	Introduction of supporting pessary into vagina NOS
42040	GP clinical event records	K510000	Cystocele without uterine prolapse
42040	GP clinical event records	K510100	Cystourethrocele without uterine prolapse
42040	GP clinical event records	K510200	Rectocele without uterine prolapse
42040	GP clinical event records	K510211	Proctocele without uterine prolapse
42040	GP clinical event records	K510300	Urethrocele without uterine prolapse
42040	GP clinical event records	K510400	Vaginal prolapse unspecified without uterine prolapse
42040	GP clinical event records	K510.00	Vaginal wall prolapse without uterine prolapse
42040	GP clinical event records	K510z00	Vaginal prolapse without uterine prolapse NOS
42040	GP clinical event records	K511000	First degree uterine prolapse
42040	GP clinical event records	K511100	Second degree uterine prolapse
42040	GP clinical event records	K511200	Third degree uterine prolapse
42040	GP clinical event records	K511.00	Uterine prolapse without vaginal wall prolapse
42040	GP clinical event records	K511.11	Descens uteri
42040	GP clinical event records	K511z00	Uterine prolapse without vaginal wall prolapse NOS
42040	GP clinical event records	K512000	Cystocele with first degree uterine prolapse
42040	GP clinical event records	K512100	Cystocele with second degree uterine prolapse
42040	GP clinical event records	K512.00	Uterovaginal prolapse, incomplete
42040	GP clinical event records	K513000	Cystocele with third degree uterine prolapse
42040	GP clinical event records	K513.00	Uterovaginal prolapse, complete
42040	GP clinical event records	K513.11	Procidentia - uterine
42040	GP clinical event records	K514000	Cystocele with unspecified uterine prolapse
42040	GP clinical event records	K514.00	Uterovaginal prolapse, unspecified
42040	GP clinical event records	K515.00	Post hysterectomy vaginal vault prolapse
42040	GP clinical event records	K516100	Acquired vaginal enterocele
42040	GP clinical event records	K516.00	Vaginal enterocele
42040	GP clinical event records	K516.11	Pelvic enterocele
42040	GP clinical event records	K516z00	Vaginal enterocele NOS
42040	GP clinical event records	K517.00	Old laceration of pelvic floor muscle
42040	GP clinical event records	K518.00	Female rectocele
42040	GP clinical event records	K519.00	Cystocele
42040	GP clinical event records	K51..00	Genital prolapse
42040	GP clinical event records	K51y000	Incompetence of pelvic fundus
42040	GP clinical event records	K51y100	Weakening of pelvic fundus
42040	GP clinical event records	K51y300	Relaxation of pelvis
42040	GP clinical event records	K51y.00	Other genital prolapse
42040	GP clinical event records	K51yz00	Other genital prolapse NOS
42040	GP clinical event records	K51z.00	Genital prolapse NOS
42040	GP clinical event records	Kyu9100	[X]Other female genital prolapse
42040	GP clinical event records	SP07900	Problem with vaginal pessary
42040	GP clinical event records	XaJzP	Cystocele with second degree uterine prolapse
42040	GP clinical event records	XE0HG	Repair of enterocele NEC
42040	GP clinical event records	XaM56	Paravaginal repair
42040	GP clinical event records	XaM53	Repair of vault of vagina with mesh using abdominal approach
42040	GP clinical event records	XE2aD	Vaginal enterocele
42040	GP clinical event records	X402n	Removal of ring pessary from vagina
42040	GP clinical event records	XE0HE	Anterior colporrhaphy NEC
42040	GP clinical event records	XE0HC	Other repair of vaginal prolapse
42040	GP clinical event records	XaF7h	Anterior mesh vaginal repair
42040	GP clinical event records	XaM54	Repair of vault of vagina with mesh using vaginal approach
42040	GP clinical event records	XaMu9	Posterior colporrhaphy with mesh reinforcement
42040	GP clinical event records	XE0HD	Anterior and posterior colporrhaphy NEC
42040	GP clinical event records	XaJzQ	Cystocele with third degree uterine prolapse
42040	GP clinical event records	XE0HH	Suture of vagina
42040	GP clinical event records	XE0HB	Repair of vaginal prolapse and amputation of cervix uteri NOS
42040	GP clinical event records	7D1B1	Insertion of ring pessary into vagina
42040	GP clinical event records	XE0HF	Posterior colporrhaphy NEC
42040	GP clinical event records	X402i	Renewal of supporting pessary in vagina
42040	GP clinical event records	XaJzO	Cystocele with first degree uterine prolapse
42040	GP clinical event records	Xa9CL	Female rectocele
42040	GP clinical event records	XE0HA	Anterior colporrhaphy and amputation of cervix uteri NEC
42040	GP clinical event records	X402f	Sacrospinous fixation of vaginal vault
42040	GP clinical event records	XaMu8	Anterior colporrhaphy with mesh reinforcement
42040	GP clinical event records	X77Sc	Cystocele
42040	GP clinical event records	XE0eY	Uterine prolapse without vaginal wall prolapse
42040	GP clinical event records	XaJzR	Cystocele with unspecified uterine prolapse