Female infertility

Metadata

Name	Female infertility (female_infertility)
Category	Genitourinary
Sex
Adult	Yes
UUID	145d0383-2a91-44cd-8760-740066b520fb
Definition	Diminished or absent ability of a female to achieve conception.

Ontologies

Disease Ontology (DOID)	DOID_13589
GWAS Catalogue	EFO_0008560
MeSH	D007247
SNOMED-CT	6738008
FinnGen	N14_FEMALEINFERT

Key Summary Statistics

Cases from any source

Total	3907
Female (%)	3907 (100%)
Male (%)	0 (0%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	224.32 (214.36,234.29)
Male	0.0 (0.0,0.0)

Incidence stratified by sex

Female	0.31 (0.16,0.45)
Male	0.0 (0.0,0.0)

Incidence stratified by age

Ages 40-44	1.24 (0.54,1.94)
Ages 45-49	0.3 (0.01,0.6)
Ages 50-54	0.0 (0.0,0.0)
Ages 55-59	0.0 (0.0,0.0)
Ages 60-64	0.04 (-0.04,0.11)
Ages 65-69	0.0 (0.0,0.0)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	215 (201,229)	107 (100,115)	58 (54,63)
CALIBER	575 (566,585)	305 (297,312)	134 (128,139)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	244(211,281)	127(110,147)	68(57,80)
Low	215(184,249)	109(93,127)	60(50,72)
Medium	222(192,256)	103(87,120)	57(47,68)
High	229(200,261)	109(93,127)	56(46,68)
Most deprived	174(150,200)	88(73,104)	49(39,60)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	201(187,216)	108(100,117)	61(55,66)
Scotland	282(240,329)	116(96,139)	67(53,83)
Wales	245(194,304)	82(60,108)	20(11,34)

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1403	female infertility
41202	Diagnoses - main ICD10	N97	Female infertility
41204	Diagnoses - secondary ICD10	N97	Female infertility
40001	Underlying (primary) cause of death: ICD10	N97	Female infertility
40002	Contributory (secondary) causes of death: ICD10	N97	Female infertility
42040	GP clinical event records	K26y300	Infertility due to radiation
42040	GP clinical event records	K26y400	Infertility in systemic disease
42040	GP clinical event records	K5B0000	Primary anovulatory infertility
42040	GP clinical event records	K5B0100	Secondary anovulatory infertility
42040	GP clinical event records	K5B0.00	Female infertility of anovulatory origin
42040	GP clinical event records	K5B0.11	Anovular cycle
42040	GP clinical event records	K5B0z00	Female infertility of anovulatory origin NOS
42040	GP clinical event records	K5B1000	Primary pituitary - hypothalamic infertility
42040	GP clinical event records	K5B1100	Secondary pituitary - hypothalamic infertility
42040	GP clinical event records	K5B1.00	Female infertility of pituitary - hypothalamic origin
42040	GP clinical event records	K5B1z00	Female infertility of pituitary - hypothalamic cause NOS
42040	GP clinical event records	K5B2000	Primary tubal infertility
42040	GP clinical event records	K5B2100	Secondary tubal infertility
42040	GP clinical event records	K5B2300	Blocked fallopian tube
42040	GP clinical event records	K5B2.00	Female infertility of tubal origin
42040	GP clinical event records	K5B2z00	Female infertility of tubal origin NOS
42040	GP clinical event records	K5B3000	Primary uterine infertility
42040	GP clinical event records	K5B3100	Secondary uterine infertility
42040	GP clinical event records	K5B3.00	Female infertility of uterine origin
42040	GP clinical event records	K5B3z00	Female infertility of uterine origin NOS
42040	GP clinical event records	K5B4000	Primary cervical infertility
42040	GP clinical event records	K5B4100	Secondary cervical infertility
42040	GP clinical event records	K5B4.00	Female infertility of cervical origin
42040	GP clinical event records	K5B5100	Secondary vaginal infertility
42040	GP clinical event records	K5B5.00	Female infertility of vaginal origin
42040	GP clinical event records	K5B6.00	Female infertility associated with male factors
42040	GP clinical event records	K5B7.00	Female infertility due to diminished ovarian reserve
42040	GP clinical event records	K5B..00	Infertility - female
42040	GP clinical event records	K5By000	Primary infertility unspecified
42040	GP clinical event records	K5By100	Secondary infertility unspecified
42040	GP clinical event records	K5By.00	Other female infertility
42040	GP clinical event records	K5Byz00	Other female infertility NOS
42040	GP clinical event records	K5Byz11	Subfertility
42040	GP clinical event records	K5Bz.00	Female infertility NOS
42040	GP clinical event records	Kyu9G00	[X]Female infertility of other origin
42040	GP clinical event records	XE0ey	Other female infertility NOS
42040	GP clinical event records	XE0ex	Female infertility of anovulatory origin
42040	GP clinical event records	XaZ6K	Female infertility due to diminished ovarian reserve
42040	GP clinical event records	X409B	Female infertility associated with male factors
42040	GP clinical event records	X4099	Blocked fallopian tube