Fibromatoses

Metadata

Name	Fibromatoses (fibromatosis)
Category	Musculoskeletal
Sex
Adult	Yes
UUID	08a93441-a07c-4e67-9f33-86371c3846bd
Definition	A group of soft tissue tumors which have certain characteristics in common, including absence of cytologic and clinical malignant features, a histology consistent with proliferation of well-differentiated fibroblasts, an infiltrative growth pattern, and aggressive clinical behavior with frequent local recurrence.

Ontologies

MeSH	D005350
SNOMED-CT	19928005

Key Summary Statistics

Cases from any source

Total	9774
Female (%)	3092 (32%)
Male (%)	6682 (68%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	69.9 (64.29,75.51)
Male	188.15 (178.19,198.12)

Incidence stratified by sex

Female	10.97 (10.1,11.83)
Male	23.95 (22.54,25.36)

Incidence stratified by age

Ages 40-44	4.54 (3.21,5.86)
Ages 45-49	6.64 (5.26,8.01)
Ages 50-54	12.91 (11.13,14.69)
Ages 55-59	18.23 (16.31,20.16)
Ages 60-64	23.09 (21.22,24.96)
Ages 65-69	23.75 (21.57,25.92)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	59 (51,67)	165 (155,176)	327 (315,339)
CALIBER	46 (44,48)	141 (138,145)	288 (283,294)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	69(51,91)	167(145,191)	331(306,358)
Low	55(38,76)	176(153,202)	336(311,363)
Medium	56(40,76)	181(158,207)	336(310,364)
High	56(41,74)	160(138,184)	331(303,360)
Most deprived	59(45,76)	143(123,165)	299(272,327)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	58(50,67)	169(158,181)	324(311,338)
Scotland	64(43,91)	112(90,137)	272(240,306)
Wales	53(29,87)	216(177,261)	444(395,497)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153520, Events=195

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.39 (0.98, 1.99)	0.068
BMI	obese	1.63 (1.11, 2.4)	0.0126
BMI	underweight	0 (0, Inf)	0.99
smoking	previous	1.5 (1.1, 2.03)	0.00988
smoking	current	1.45 (0.93, 2.27)	0.0986
hypertension	yes	1.38 (0.98, 1.93)	0.0624

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1540	plantar fascitis
20002	Non-cancer illness code, self-reported	1544	dupuytren’s contracture
41202	Diagnoses - main ICD10	M72.0	Palmar fascial fibromatosis [Dupuytren]
41202	Diagnoses - main ICD10	M72.1	Knuckle pads
41204	Diagnoses - secondary ICD10	M72.0	Palmar fascial fibromatosis [Dupuytren]
41204	Diagnoses - secondary ICD10	M72.1	Knuckle pads
41200	Operative procedures - main OPCS4	T52.1	Palmar fasciectomy
41200	Operative procedures - main OPCS4	T52.2	Revision of palmar fasciectomy
41200	Operative procedures - main OPCS4	T54.1	Division of palmar fascia
41210	Operative procedures - secondary OPCS4	T52.1	T52.1
41210	Operative procedures - secondary OPCS4	T52.2	T52.2
41210	Operative procedures - secondary OPCS4	T54.1	T54.1
40001	Underlying (primary) cause of death: ICD10	M72.0	Palmar fascial fibromatosis [Dupuytren]
40001	Underlying (primary) cause of death: ICD10	M72.1	Knuckle pads
40002	Contributory (secondary) causes of death: ICD10	M72.0	Palmar fascial fibromatosis [Dupuytren]
40002	Contributory (secondary) causes of death: ICD10	M72.1	Knuckle pads
42040	GP clinical event records	7H32000	Palmar fasciectomy unspecified
42040	GP clinical event records	7H32011	Dupuytren hand fasciectomy
42040	GP clinical event records	7H32013	McIndoe radical palmar fasciectomy
42040	GP clinical event records	7H32100	Revision of palmar fasciectomy
42040	GP clinical event records	7H32400	Limited palmar fasciectomy
42040	GP clinical event records	7H32500	Radical palmar fasciectomy
42040	GP clinical event records	7H32700	Palmar fasciectomy using open palm technique
42040	GP clinical event records	7H34000	Division of palmar fascia
42040	GP clinical event records	7H34011	Division of hand fascia
42040	GP clinical event records	7H34012	Dupuytren hand fasciotomy
42040	GP clinical event records	7H34300	Needle fasciotomy of hand
42040	GP clinical event records	7H35700	Fasciotomy hand
42040	GP clinical event records	N236000	Dupuytren’s disease of palm
42040	GP clinical event records	N236100	Dupuytren’s disease of palm, nodules with no contracture
42040	GP clinical event records	N236200	Dupuytren’s disease of palm, with contracture
42040	GP clinical event records	N236300	Dupuytren’s disease of finger(s)
42040	GP clinical event records	N236400	Dupuytren’s disease - finger(s), nodules with no contracture
42040	GP clinical event records	N236500	Dupuytren’s disease of finger(s), with contracture
42040	GP clinical event records	N236600	Dupuytren’s disease of palm and finger(s)
42040	GP clinical event records	N236700	Dupuytren’s dis, palm and finger(s), nodules, no contracture
42040	GP clinical event records	N236800	Dupuytren’s disease of palm and finger(s), with contracture
42040	GP clinical event records	N236.00	Dupuytren’s contracture
42040	GP clinical event records	N236.11	Palmar fascia contracture
42040	GP clinical event records	N237100	Knuckle pads
42040	GP clinical event records	XaXYd	Needle fasciotomy of hand
42040	GP clinical event records	XM0ug	Dupuytren’s contracture
42040	GP clinical event records	XE04t	Division of palmar fascia
42040	GP clinical event records	XE04s	Palmar fasciectomy unspecified