| Name |
Folate deficiency anaemia (folatedef) |
| Category |
Haematological or immunological |
| Sex |
|
| Adult |
Yes |
| UUID |
842036eb-0ef4-4c22-90fc-a808b3aaafd7 |
| Definition |
A nutritional deficiency disease that is characterized by a decrease in red blood cells due to lack of folate, has_material_basis in insufficient folic acid in diet, hemolytic anemia, alcoholism, and/or certain medicines. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
1435 |
| Female (%) |
715 (50%) |
| Male (%) |
720 (50%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
13.32 (10.87,15.77) |
| Male |
9.1 (6.89,11.31) |
Incidence stratified by sex
| Female |
3.06 (2.61,3.52) |
| Male |
3.75 (3.2,4.3) |
Incidence stratified by age
| Ages 40-44 |
3.63 (2.44,4.81) |
| Ages 45-49 |
2.82 (1.92,3.72) |
| Ages 50-54 |
2.47 (1.7,3.25) |
| Ages 55-59 |
2.55 (1.84,3.26) |
| Ages 60-64 |
3.69 (2.95,4.43) |
| Ages 65-69 |
4.73 (3.77,5.68) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
29 (24,35) |
25 (22,29) |
35 (32,39) |
| CALIBER |
9 (8,10) |
14 (13,15) |
21 (20,23) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
9(4,18) |
14(8,21) |
21(15,29) |
| Low |
24(14,38) |
14(9,23) |
35(27,45) |
| Medium |
29(18,44) |
19(12,28) |
26(19,34) |
| High |
29(19,42) |
31(22,42) |
37(28,47) |
| Most deprived |
46(34,61) |
47(36,60) |
63(51,76) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
30(24,36) |
25(21,30) |
36(32,41) |
| Scotland |
21(11,37) |
29(19,43) |
40(29,54) |
| Wales |
31(14,58) |
18(9,33) |
19(10,33) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153321, Events=259
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
1.47 (1.07, 2.01) |
0.0165 |
| BMI |
obese |
2.46 (1.81, 3.35) |
1.19e-08 |
| BMI |
underweight |
0 (0, Inf) |
0.998 |
| smoking |
previous |
1.06 (0.81, 1.39) |
0.676 |
| smoking |
current |
0.75 (0.46, 1.22) |
0.25 |
| hypertension |
yes |
0.83 (0.58, 1.19) |
0.31 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 41202 |
Diagnoses - main ICD10 |
D52 |
Folate deficiency anaemia |
| 41204 |
Diagnoses - secondary ICD10 |
D52 |
Folate deficiency anaemia |
| 40001 |
Underlying (primary) cause of death: ICD10 |
D52 |
Folate deficiency anaemia |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
D52 |
Folate deficiency anaemia |
| 42040 |
GP clinical event records |
C262000 |
Folic acid deficiency |
| 42040 |
GP clinical event records |
D012100 |
Folate-deficiency anaemia due to dietary causes |
| 42040 |
GP clinical event records |
D012111 |
Goat’s milk anaemia |
| 42040 |
GP clinical event records |
D012200 |
Folate-deficiency anaemia, drug induced |
| 42040 |
GP clinical event records |
D012300 |
Folate-deficiency anaemia due to malabsorption |
| 42040 |
GP clinical event records |
D012400 |
Folate-deficiency anaemia due to liver disorders |
| 42040 |
GP clinical event records |
D012.00 |
Folate-deficiency anaemia |
| 42040 |
GP clinical event records |
D012.11 |
Folic acid deficiency anaemia |
| 42040 |
GP clinical event records |
D012z00 |
Folate-deficiency anaemia NOS |
| 42040 |
GP clinical event records |
D013000 |
Combined B12 and folate deficiency anaemia |
| 42040 |
GP clinical event records |
Dyu0300 |
[X]Other folate deficiency anaemias |