Metadata

Name Fracture of hip (fracture_hip)
Category Musculoskeletal
Sex
Adult Yes
UUID 5dbb668a-26a0-4c71-82ab-42454e9dec2e
Definition Fractures of the FEMUR HEAD; the FEMUR NECK; (FEMORAL NECK FRACTURES); the trochanters; or the inter- or subtrochanteric region.

Ontologies

GWAS Catalogue EFO_0003964
MeSH D006620
SNOMED-CT 700097003
FinnGen ST19_FRACT_FEMUR

Key Summary Statistics

Cases from any source

Total 5863
Female (%) 3665 (63%)
Male (%) 2198 (37%)

Year first recorded

fracture_hip year of first event

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Cross-sourced fracture_hip cases

Incidence & prevalence

Sex and age-stratified incidence and prevalence of fracture_hip

Baseline prevalence stratified by sex

Female 24.4 (21.08,27.72)
Male 35.98 (31.59,40.37)

Incidence stratified by sex

Female 6.21 (5.56,6.86)
Male 3.93 (3.36,4.49)

Incidence stratified by age

Ages 40-44 1.81 (0.97,2.65)
Ages 45-49 2.01 (1.25,2.76)
Ages 50-54 2.22 (1.49,2.96)
Ages 55-59 3.7 (2.84,4.56)
Ages 60-64 6.21 (5.25,7.17)
Ages 65-69 11.42 (9.93,12.91)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

CALIBER and UKB fracture_hip prevalence comparison for multiple age groups

Population Ages 40-49 Ages 50-59 Ages 60-69
UK Biobank 22 (18,28) 41 (36,46) 80 (75,86)
CALIBER 24 (22,25) 48 (46,51) 110 (107,113)

Stratified by age and Townsend deprivation status

Deprivation status Ages 40-49 Ages 50-59 Ages 60-69
Least deprived 19(10,33) 32(23,43) 67(56,79)
Low 23(13,38) 37(27,48) 71(60,84)
Medium 15(8,27) 35(26,47) 82(70,96)
High 29(19,43) 46(35,59) 77(65,92)
Most deprived 24(15,35) 54(42,69) 111(95,129)

Stratified by age and country

Country Ages 40-49 Ages 50-59 Ages 60-69
England 19(14,24) 40(34,46) 75(69,82)
Scotland 45(28,70) 51(37,68) 121(101,144)
Wales 28(12,54) 39(24,60) 71(52,94)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153520, Events=195

Factor Level Hazard Ratio P value
BMI overweight 1.39 (0.98, 1.99) 0.068
BMI obese 1.63 (1.11, 2.4) 0.0126
BMI underweight 0 (0, Inf) 0.99
smoking previous 1.5 (1.1, 2.03) 0.00988
smoking current 1.45 (0.93, 2.27) 0.0986
hypertension yes 1.38 (0.98, 1.93) 0.0624

Risk factors analysis forest plot

Definition

UK Biobank field id Description Code Value
20002 Non-cancer illness code, self-reported 1648 fracture neck of femur / hip
41202 Diagnoses - main ICD10 S72.0 Fracture of neck of femur
41202 Diagnoses - main ICD10 S72.1 Pertrochanteric fracture
41202 Diagnoses - main ICD10 S72.2 Subtrochanteric fracture
41204 Diagnoses - secondary ICD10 S72.0 Fracture of neck of femur
41204 Diagnoses - secondary ICD10 S72.1 Pertrochanteric fracture
41204 Diagnoses - secondary ICD10 S72.2 Subtrochanteric fracture
41200 Operative procedures - main OPCS4 W19.1 Primary open reduction of fracture of neck of femur and open fixation using pin and plate
41200 Operative procedures - main OPCS4 W24.1 Closed reduction of intracapsular fracture of neck of femur and fixation using nail or screw
41200 Operative procedures - main OPCS4 O17.1 Remanipulation of intracapsular fracture of neck of femur and fixation using nail or screw
41210 Operative procedures - secondary OPCS4 W19.1 W19.1
41210 Operative procedures - secondary OPCS4 W24.1 W24.1
41210 Operative procedures - secondary OPCS4 O17.1 O17.1
40001 Underlying (primary) cause of death: ICD10 S72.0 Fracture of neck of femur
40001 Underlying (primary) cause of death: ICD10 S72.1 Pertrochanteric fracture
40001 Underlying (primary) cause of death: ICD10 S72.2 Subtrochanteric fracture
40002 Contributory (secondary) causes of death: ICD10 S72.0 Fracture of neck of femur
40002 Contributory (secondary) causes of death: ICD10 S72.1 Pertrochanteric fracture
40002 Contributory (secondary) causes of death: ICD10 S72.2 Subtrochanteric fracture
42040 GP clinical event records 14G7.00 H/O: hip fracture
42040 GP clinical event records 7K1D000 Prmy open red+int fxn prox femoral #+screw/nail+plate device
42040 GP clinical event records 7K1D011 Prim open reduct # neck femur & op fix - Blount nail plate
42040 GP clinical event records 7K1D012 Prim op red # nck femur & op fix- Charnley compression screw
42040 GP clinical event records 7K1D013 Prim op red # nck femur & op fix - Deyerle multiple hip pin
42040 GP clinical event records 7K1D014 Prim open reduct # neck femur & op fix - Holt nail
42040 GP clinical event records 7K1D015 Prim open reduct # neck femur & op fix - Jewett nail plate
42040 GP clinical event records 7K1D016 Prim open reduct # neck femur & op fix - Massie nail plate
42040 GP clinical event records 7K1D017 Prim open red # neck femur & op fix - McLaughlin nail plate
42040 GP clinical event records 7K1D018 Prim open reduct # neck femur & op fix - Neufield nail plate
42040 GP clinical event records 7K1D019 Prim open reduct # neck femur & op fix - Pugh nail plate
42040 GP clinical event records 7K1D01A Prim open reduct # neck femur & op fix - Richards screw
42040 GP clinical event records 7K1D01B Prim open reduct # neck femur & op fix - Ross Brown nail
42040 GP clinical event records 7K1D01D Prim op red # nck femur & op fix- Zickel intramed nail plate
42040 GP clinical event records 7K1D01E DHS - Dynamic hip screw primary fixation of neck of femur
42040 GP clinical event records 7K1D01F Dynamic hip screw primary fixation of neck of femur
42040 GP clinical event records 7K1D600 Prmy open red+int fxn prox femoral #+screw/nail device alone
42040 GP clinical event records 7K1D700 Prmy open red+int fxn prox fem #+screw/nail+intramed device
42040 GP clinical event records 7K1DE00 Prim op red frac neck fem op fix us prox fem nail antirotatn
42040 GP clinical event records 7K1H500 Revision to open red+ext fxtn of proximal femoral #
42040 GP clinical event records 7K1H600 Revsn to opn red+int fxtn prox fem #+screw/nail device alone
42040 GP clinical event records 7K1H700 Rvsn to opn red+int fxtn prox fem #+ scrw/nl+intramed device
42040 GP clinical event records 7K1H800 Rvsn to opn red+int fxtn prox fem #+ scrw/nail+plate device
42040 GP clinical event records 7K1J000 Cls red+int fxn proximal femoral #+screw/nail device alone
42040 GP clinical event records 7K1J011 Cl red intracaps frac neck femur fix-Garden cannulated screw
42040 GP clinical event records 7K1J012 Cl red intracaps fract neck femur fix - Smith-Petersen nail
42040 GP clinical event records 7K1J013 Cls red+int fxn prox femoral #+Richard’s cannulat hip screw
42040 GP clinical event records 7K1J500 Primary int fxn(no red) prox fem #+screw/nail device alone
42040 GP clinical event records 7K1J600 Primary int fxn(no red) prox fem #+scrw/nail+intramed device
42040 GP clinical event records 7K1J700 Primary int fxn(no red) prox fem #+screw/nail+plate device
42040 GP clinical event records 7K1J800 Revisn to int fxn(no red) prox fem #+screw/nail device alone
42040 GP clinical event records 7K1J900 Rvsn to int fxn(no red) prox fem #+screw/nail+intramed dev
42040 GP clinical event records 7K1JA00 Revisn to int fxn(no red) prox fem #+screw/nail+plate device
42040 GP clinical event records 7K1JB00 Primary cls red+int fxn prox fem #+screw/nail device alone
42040 GP clinical event records 7K1JC00 Prim cls rd+int fxn prox fem #+screw/nail+intramdulry device
42040 GP clinical event records 7K1Jd00 Closed reduction of intracapsular # NOF internal fixat DHS
42040 GP clinical event records 7K1JD00 Primary cls red+int fxn prox fem #+screw/nail+plate device
42040 GP clinical event records 7K1JE00 Rvsn to cls red+int fxn prox fem #+screw/nail device alone
42040 GP clinical event records 7K1JF00 Rvsn cls red+int fxn prox fem #+screw/nail+intramed device
42040 GP clinical event records 7K1JG00 Rvsn to cls red+int fxn prox fem #+screw/nail+plate device
42040 GP clinical event records 7K1K300 Primary external fixation(without reduction) prox femoral #
42040 GP clinical event records 7K1K400 Revision to ext fxn(without reduction) proximal femoral #
42040 GP clinical event records 7K1K500 Primary cls reduction+external fixation proximal femoral #
42040 GP clinical event records 7K1L400 Closed reduction of fracture of hip
42040 GP clinical event records 7K1Y000 Remanip intracap fract neck fem and fix using nail or screw
42040 GP clinical event records 7P20100 Delivery of rehabilitation for hip fracture
42040 GP clinical event records S300000 Cls # prox femur, intracapsular section, unspecified
42040 GP clinical event records S300100 Closed fracture proximal femur, transepiphyseal
42040 GP clinical event records S300200 Closed fracture proximal femur, midcervical section
42040 GP clinical event records S300300 Closed fracture proximal femur, basicervical
42040 GP clinical event records S300311 Closed fracture, base of neck of femur
42040 GP clinical event records S300400 Closed fracture head of femur
42040 GP clinical event records S300500 Cls # prox femur, subcapital, Garden grade unspec.
42040 GP clinical event records S300600 Closed fracture proximal femur, subcapital, Garden grade I
42040 GP clinical event records S300700 Closed fracture proximal femur, subcapital, Garden grade II
42040 GP clinical event records S300800 Closed fracture proximal femur, subcapital, Garden grade III
42040 GP clinical event records S300900 Closed fracture proximal femur, subcapital, Garden grade IV
42040 GP clinical event records S300A00 Closed fracture of femur, upper epiphysis
42040 GP clinical event records S300.00 Closed fracture proximal femur, transcervical
42040 GP clinical event records S300y00 Closed fracture proximal femur, other transcervical
42040 GP clinical event records S300y11 Closed fracture of femur, subcapital
42040 GP clinical event records S300z00 Closed fracture proximal femur, transcervical, NOS
42040 GP clinical event records S301000 Opn # proximal femur, intracapsular section, unspecified
42040 GP clinical event records S301100 Open fracture proximal femur, transepiphyseal
42040 GP clinical event records S301311 Open fracture base of neck of femur
42040 GP clinical event records S301400 Open fracture head, femur
42040 GP clinical event records S301500 Open fracture proximal femur,subcapital, Garden grade unspec
42040 GP clinical event records S301600 Open fracture proximal femur,subcapital, Garden grade I
42040 GP clinical event records S301700 Open fracture proximal femur,subcapital, Garden grade II
42040 GP clinical event records S301800 Open fracture proximal femur,subcapital, Garden grade III
42040 GP clinical event records S301900 Open fracture proximal femur,subcapital, Garden grade IV
42040 GP clinical event records S301A00 Open fracture of femur, upper epiphysis
42040 GP clinical event records S301.00 Open fracture proximal femur, transcervical
42040 GP clinical event records S301y00 Open fracture proximal femur, other transcervical
42040 GP clinical event records S301y11 Open fracture of femur, subcapital
42040 GP clinical event records S302000 Cls # proximal femur, trochanteric section, unspecified
42040 GP clinical event records S302011 Closed fracture of femur, greater trochanter
42040 GP clinical event records S302012 Closed fracture of femur, lesser trochanter
42040 GP clinical event records S302100 Closed fracture proximal femur, intertrochanteric, two part
42040 GP clinical event records S302200 Closed fracture proximal femur, subtrochanteric
42040 GP clinical event records S302300 Cls # proximal femur, intertrochanteric, comminuted
42040 GP clinical event records S302400 Closed fracture of femur, intertrochanteric
42040 GP clinical event records S302.00 Closed fracture of proximal femur, pertrochanteric
42040 GP clinical event records S302z00 Cls # of proximal femur, pertrochanteric section, NOS
42040 GP clinical event records S303000 Open # of proximal femur, trochanteric section, unspecified
42040 GP clinical event records S303011 Open fracture of femur, greater trochanter
42040 GP clinical event records S303100 Open fracture proximal femur, intertrochanteric, two part
42040 GP clinical event records S303200 Open fracture proximal femur, subtrochanteric
42040 GP clinical event records S303300 Open fracture proximal femur, intertrochanteric, comminuted
42040 GP clinical event records S303400 Open fracture of femur, intertrochanteric
42040 GP clinical event records S303.00 Open fracture of proximal femur, pertrochanteric
42040 GP clinical event records S303z00 Open fracture of proximal femur, pertrochanteric, NOS
42040 GP clinical event records S304.00 Pertrochanteric fracture
42040 GP clinical event records S305.00 Subtrochanteric fracture
42040 GP clinical event records S30..00 Fracture of neck of femur
42040 GP clinical event records S30..11 Hip fracture
42040 GP clinical event records S30w.00 Closed fracture of unspecified proximal femur
42040 GP clinical event records S30x.00 Open fracture of unspecified proximal femur
42040 GP clinical event records S30y.00 Closed fracture of neck of femur NOS
42040 GP clinical event records S30y.11 Hip fracture NOS
42040 GP clinical event records S30z.00 Open fracture of neck of femur NOS
42040 GP clinical event records S4E0.00 Closed fracture-dislocation, hip joint
42040 GP clinical event records S4E1.00 Open fracture-dislocation, hip joint
42040 GP clinical event records S4E2.00 Closed fracture-subluxation, hip joint
42040 GP clinical event records S4E..00 Fracture-dislocation or subluxation hip
42040 GP clinical event records SC03.00 Late effect of fracture neck of femur
42040 GP clinical event records XaIUB H/O: hip fracture
42040 GP clinical event records XaKye Closed fracture of femur, upper epiphysis
42040 GP clinical event records XE1l3 Fracture of neck of femur
42040 GP clinical event records XE1l7 Closed fracture of proximal femur, trochanteric section, unspecified
42040 GP clinical event records XaBDU Closed fracture of femur, intertrochanteric
42040 GP clinical event records XaPtb Remanipulation of intracapsular fracture of neck of femur and fixation using nail or screw
42040 GP clinical event records XaZjg Primary open reduction of fracture of neck of femur and open fixation using proximal femoral nail antirotation
42040 GP clinical event records XE08S Closed reduction and internal fixation of proximal femoral fracture with screw/nail device alone
42040 GP clinical event records XE08S Closed reduction and internal fixation of proximal femoral fracture with screw/nail device alone
42040 GP clinical event records XE1l5 Open fracture proximal femur, basicervical
42040 GP clinical event records XE1l8 Open fracture of proximal femur, trochanteric section, unspecified
42040 GP clinical event records XE1l6 Open fracture proximal femur, other transcervical
42040 GP clinical event records XE1l9 Closed fracture of neck of femur NOS
42040 GP clinical event records XE08J Primary open reduction and internal fixation of proximal femoral fracture with screw/nail and plate device
42040 GP clinical event records XaEJD Closed reduction of intracapsular fracture of neck of femur and internal fixation using a dynamic hip screw
42040 GP clinical event records XaBDT Open fracture of femur, intertrochanteric
42040 GP clinical event records XaLsh Delivery of rehabilitation for hip fracture
42040 GP clinical event records XE1l4 Closed fracture proximal femur, other transcervical
42040 GP clinical event records XaKyf Open fracture of femur, upper epiphysis