Fracture of wrist

Metadata

Name	Fracture of wrist (fracture_wrist)
Category	Musculoskeletal
Sex
Adult	Yes
UUID	3f8e0339-b66f-449f-b1a4-6c2862500224
Definition	A break of the part of the radius bone which is close to the wrist.

Ontologies

GWAS Catalogue	EFO_0009515
MeSH	D003100
SNOMED-CT	208388003
FinnGen	ST19_FRACT_WRIST_HAND_LEVEL

Key Summary Statistics

Cases from any source

Total	15317
Female (%)	10732 (70%)
Male (%)	4585 (30%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	251.9 (241.36,262.45)
Male	208.31 (197.84,218.78)

Incidence stratified by sex

Female	25.03 (23.71,26.35)
Male	6.0 (5.3,6.71)

Incidence stratified by age

Ages 40-44	7.18 (5.5,8.86)
Ages 45-49	7.72 (6.22,9.22)
Ages 50-54	16.29 (14.28,18.31)
Ages 55-59	18.11 (16.18,20.03)
Ages 60-64	19.28 (17.56,20.99)
Ages 65-69	21.27 (19.21,23.34)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	183 (170,196)	244 (233,256)	336 (325,348)
CALIBER	221 (217,225)	266 (261,271)	352 (346,358)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	201(169,237)	227(202,254)	348(323,375)
Low	178(148,212)	244(218,272)	320(296,346)
Medium	203(172,238)	254(228,283)	331(306,358)
High	191(163,222)	252(226,280)	320(294,347)
Most deprived	152(129,178)	244(219,272)	367(338,398)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	160(146,174)	228(215,241)	317(304,330)
Scotland	322(273,377)	340(303,380)	455(417,496)
Wales	213(164,272)	246(206,291)	353(310,399)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153520, Events=195

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.39 (0.98, 1.99)	0.068
BMI	obese	1.63 (1.11, 2.4)	0.0126
BMI	underweight	0 (0, Inf)	0.99
smoking	previous	1.5 (1.1, 2.03)	0.00988
smoking	current	1.45 (0.93, 2.27)	0.0986
hypertension	yes	1.38 (0.98, 1.93)	0.0624

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1637	fracture wrist / colles fracture
20002	Non-cancer illness code, self-reported	1634	fracture forearm / wrist
41202	Diagnoses - main ICD10	S52.5	Fracture of lower end of radius
41202	Diagnoses - main ICD10	S52.6	Fracture of lower end of both ulna and radius
41204	Diagnoses - secondary ICD10	S52.5	Fracture of lower end of radius
41204	Diagnoses - secondary ICD10	S52.6	Fracture of lower end of both ulna and radius
40001	Underlying (primary) cause of death: ICD10	S52.5	Fracture of lower end of radius
40001	Underlying (primary) cause of death: ICD10	S52.6	Fracture of lower end of both ulna and radius
40002	Contributory (secondary) causes of death: ICD10	S52.5	Fracture of lower end of radius
40002	Contributory (secondary) causes of death: ICD10	S52.6	Fracture of lower end of both ulna and radius
42040	GP clinical event records	7K1LM00	Closed reduction of fracture of wrist
42040	GP clinical event records	S234000	Closed fracture of forearm, lower end, unspecified
42040	GP clinical event records	S234100	Closed Colles’ fracture
42040	GP clinical event records	S234111	Smith’s fracture - closed
42040	GP clinical event records	S234200	Closed fracture of the distal radius, unspecified
42040	GP clinical event records	S234300	Closed fracture of ulna, styloid process
42040	GP clinical event records	S234400	Closed fracture of ulna, lower epiphysis
42040	GP clinical event records	S234500	Closed fracture distal ulna, unspecified
42040	GP clinical event records	S234600	Closed fracture radius and ulna, distal
42040	GP clinical event records	S234700	Closed Smith’s fracture
42040	GP clinical event records	S234800	Closed Galeazzi fracture
42040	GP clinical event records	S234900	Closed volar Barton’s fracture
42040	GP clinical event records	S234911	Closed volar Barton’s fracture-dislocation
42040	GP clinical event records	S234912	Closed volar Barton fracture-subluxation
42040	GP clinical event records	S234A00	Closd dorsal Barton’s fracture
42040	GP clinical event records	S234A11	Closed dorsal Barton’s fracture-dislocation
42040	GP clinical event records	S234A12	Closed dorsal Barton fracture-subluxation
42040	GP clinical event records	S234B00	Closed fracture radial styloid
42040	GP clinical event records	S234C00	Closed fracture distal radius, intra-articular, die-punch
42040	GP clinical event records	S234D00	Closed fracture distal radius, extra-articular, other type
42040	GP clinical event records	S234E00	Closed fracture distal radius, intra-articular, other type
42040	GP clinical event records	S234F00	Closed Barton’s fracture
42040	GP clinical event records	S234.00	Closed fracture of radius and ulna, lower end
42040	GP clinical event records	S234.11	Wrist fracture - closed
42040	GP clinical event records	S234z00	Closed fracture of forearm, lower end, NOS
42040	GP clinical event records	S235000	Open fracture of forearm, lower end, unspecified
42040	GP clinical event records	S235100	Open Colles’ fracture
42040	GP clinical event records	S235111	Smith’s fracture - open
42040	GP clinical event records	S235200	Open fracture of the distal radius, unspecified
42040	GP clinical event records	S235300	Open fracture of ulna, styloid process
42040	GP clinical event records	S235400	Open fracture of ulna, lower epiphysis
42040	GP clinical event records	S235500	Open fracture distal ulna - other
42040	GP clinical event records	S235600	Open fracture radius and ulna, distal
42040	GP clinical event records	S235700	Open Smith’s fracture
42040	GP clinical event records	S235800	Open Galeazzi fracture
42040	GP clinical event records	S235900	Open volar Barton’s fracture
42040	GP clinical event records	S235B00	Open fracture radial styloid
42040	GP clinical event records	S235C00	Open fracture distal radius, intra-articular, die-punch
42040	GP clinical event records	S235D00	Open fracture distal radius, extra-articular other type
42040	GP clinical event records	S235E00	Open fracture distal radius, intra-articular other type
42040	GP clinical event records	S235F00	Open Barton’s fracture
42040	GP clinical event records	S235.00	Open fracture of radius and ulna, lower end
42040	GP clinical event records	S235.11	Wrist fracture - open
42040	GP clinical event records	S235z00	Open fracture of forearm, lower end, NOS
42040	GP clinical event records	S23B.00	Fracture of lower end of radius
42040	GP clinical event records	S23C.00	Fracture of lower end of both ulna and radius
42040	GP clinical event records	S4C0000	Closed fracture-dislocation distal radio-ulnar joint
42040	GP clinical event records	S4C0100	Closed fracture-dislocation radiocarpal joint
42040	GP clinical event records	S4C0.00	Closed fracture dislocation of wrist
42040	GP clinical event records	S4C1000	Open fracture-dislocation, distal radio-ulnar joint
42040	GP clinical event records	S4C1100	Open fracture-dislocation radiocarpal joint
42040	GP clinical event records	S4C1.00	Open fracture dislocation wrist
42040	GP clinical event records	S4C2000	Closed fracture-subluxation, distal radio-ulnar jt
42040	GP clinical event records	S4C2100	Closed fracture-subluxation radiocarpal joint
42040	GP clinical event records	S4C2.00	Closed fracture-subluxation of the wrist
42040	GP clinical event records	S4C3000	Open fracture-subluxation, distal radio-ulnar joint
42040	GP clinical event records	S4C3100	Open fracture-subluxation radiocarpal joint
42040	GP clinical event records	S4C3.00	Open fracture-subluxation of the wrist
42040	GP clinical event records	S4C..00	Fracture-dislocation or subluxation of wrist
42040	GP clinical event records	SC3C000	Sequelae of fracture at wrist and hand level
42040	GP clinical event records	XE1kx	Open Colles’ fracture
42040	GP clinical event records	XE1ky	Open fracture of the distal radius, unspecified
42040	GP clinical event records	XE1kw	Open fracture of radius and ulna, lower end
42040	GP clinical event records	XaBDD	Open Barton’s fracture
42040	GP clinical event records	XE1kt	Closed fracture of radius and ulna, lower end
42040	GP clinical event records	XE1kv	Closed fracture of the distal radius, unspecified
42040	GP clinical event records	XaBDE	Closed Barton’s fracture
42040	GP clinical event records	XE1ku	Closed Colles’ fracture