Metadata
| Name | Gastritis and duodenitis (gastritis_duodenitis) |
| Category | Digestive |
| Sex | |
| Adult | Yes |
| UUID | c97872c5-a1f5-4f75-84bf-6cd0aef61393 |
| Definition | Inflammation of regions of the digestive tract (stomach lining and duodenum). |
Ontologies
| Disease Ontology (DOID) | DOID_8644 |
| SNOMED-CT | 196731005 |
Key Summary Statistics
Cases from any source
| Total | 63275 |
| Female (%) | 34141 (54%) |
| Male (%) | 29134 (46%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female | 596.34 (580.41,612.28) |
| Male | 688.21 (669.64,706.77) |
Incidence stratified by sex
| Female | 74.78 (72.44,77.12) |
| Male | 73.78 (71.22,76.34) |
Incidence stratified by age
| Ages 40-44 | 39.14 (35.15,43.12) |
| Ages 45-49 | 56.29 (52.15,60.43) |
| Ages 50-54 | 62.72 (58.67,66.77) |
| Ages 55-59 | 74.01 (70.0,78.02) |
| Ages 60-64 | 88.31 (84.51,92.11) |
| Ages 65-69 | 97.48 (92.87,102.09) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| UK Biobank | 733 (707,760) | 982 (958,1006) | 1307 (1284,1331) |
| CALIBER | 615 (608,621) | 840 (831,848) | 1101 (1090, |
Stratified by age and Townsend deprivation status
| Deprivation status | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| Least deprived | 607(551,667) | 798(750,848) | 1136(1089,1184) |
| Low | 609(552,669) | 807(758,858) | 1197(1149,1246) |
| Medium | 703(644,766) | 967(914,1023) | 1289(1238,1341) |
| High | 733(678,792) | 982(929,1037) | 1352(1298,1409) |
| Most deprived | 928(870,988) | 1337(1276,1401) | 1629(1567,1693) |
Stratified by age and country
| Country | Ages 40-49 | Ages 50-59 | Ages 60-69 |
| England | 746(717,776) | 1002(975,1030) | 1338(1311,1365) |
| Scotland | 584(518,655) | 819(760,881) | 1130(1067,1196) |
| Wales | 843(742,954) | 1056(969,1147) | 1260(1177,1346) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153646, Events=402
| Factor | Level | Hazard Ratio | P value |
| BMI | overweight | 1.07 (0.82, 1.39) | 0.637 |
| BMI | obese | 2.13 (1.65, 2.77) | 1.06e-08 |
| BMI | underweight | 0 (0, Inf) | 0.986 |
| smoking | previous | 1.48 (1.19, 1.85) | 0.000498 |
| smoking | current | 2.47 (1.87, 3.26) | 1.43e-10 |
| hypertension | yes | 2.21 (1.8, 2.72) | 5.76e-14 |
Definition
| UK Biobank field id | Description | Code | Value |
|---|---|---|---|
| 20002 | Non-cancer illness code, self-reported | 1143 | gastritis/gastric erosions |
| 41202 | Diagnoses - main ICD10 | K29 | Gastritis and duodenitis |
| 41204 | Diagnoses - secondary ICD10 | K29 | Gastritis and duodenitis |
| 40001 | Underlying (primary) cause of death: ICD10 | K29 | Gastritis and duodenitis |
| 40002 | Contributory (secondary) causes of death: ICD10 | K29 | Gastritis and duodenitis |
| 42040 | GP clinical event records | A074313 | Helicobacter gastritis |
| 42040 | GP clinical event records | J11z.11 | Gastric erosions |
| 42040 | GP clinical event records | J123.00 | Duodenal erosion |
| 42040 | GP clinical event records | J150000 | Acute haemorrhagic gastritis |
| 42040 | GP clinical event records | J150.00 | Acute gastritis |
| 42040 | GP clinical event records | J151000 | Chronic atrophic gastritis |
| 42040 | GP clinical event records | J151100 | Chronic inflammatory gastritis |
| 42040 | GP clinical event records | J151200 | Chronic superficial gastritis |
| 42040 | GP clinical event records | J151.00 | Chronic gastritis |
| 42040 | GP clinical event records | J151z00 | Chronic gastritis NOS |
| 42040 | GP clinical event records | J152.00 | Gastric mucosal hypertrophy |
| 42040 | GP clinical event records | J153.00 | Alcoholic gastritis |
| 42040 | GP clinical event records | J154000 | Allergic gastritis |
| 42040 | GP clinical event records | J154100 | Bile induced gastritis |
| 42040 | GP clinical event records | J154200 | Irritant gastritis |
| 42040 | GP clinical event records | J154300 | Corrosive gastritis |
| 42040 | GP clinical event records | J154400 | Helicobacter gastritis |
| 42040 | GP clinical event records | J154.00 | Other specified gastritis |
| 42040 | GP clinical event records | J154z00 | Other specified gastritis NOS |
| 42040 | GP clinical event records | J155.00 | Gastritis unspecified |
| 42040 | GP clinical event records | J156.00 | Gastroduodenitis unspecified |
| 42040 | GP clinical event records | J157.00 | Duodenitis |
| 42040 | GP clinical event records | J15..00 | Gastritis and duodenitis |
| 42040 | GP clinical event records | J15z.00 | Gastritis and duodenitis NOS |
| 42040 | GP clinical event records | J4z0.00 | Non-infective gastritis NOS |
| 42040 | GP clinical event records | Jyu1200 | [X]Other acute gastritis |
| 42040 | GP clinical event records | Jyu1300 | [X]Other gastritis |
| 42040 | GP clinical event records | ZV65316 | [V]Dietary counselling in gastritis |
| 42040 | GP clinical event records | X302G | Duodenal erosion |
| 42040 | GP clinical event records | X301O | Acute haemorrhagic gastritis |
| 42040 | GP clinical event records | XE0aQ | Gastric ulcer NOS |
| 42040 | GP clinical event records | X301R | Helicobacter gastritis |
| 42040 | GP clinical event records | XE0Ql | Campylobacter gastrointestinal tract infection |
| 42040 | GP clinical event records | XE0Ql | Campylobacter gastrointestinal tract infection |