| Name |
Giant Cell arteritis (GCA) |
| Category |
Musculoskeletal |
| Sex |
|
| Adult |
Yes |
| UUID |
7c01eec4-f868-4174-97d3-95c0b0aa1b3a |
| Definition |
Giant cell arteritis (GCA) is a large vessel vasculitis predominantly involving the arteries originating from the aortic arch and especially the extracranial branches of the carotid arteries. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
1311 |
| Female (%) |
932 (71%) |
| Male (%) |
379 (29%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
9.78 (7.68,11.89) |
| Male |
5.18 (3.51,6.85) |
Incidence stratified by sex
| Female |
2.39 (1.99,2.79) |
| Male |
1.22 (0.91,1.54) |
Incidence stratified by age
| Ages 40-44 |
0.2 (-0.08,0.48) |
| Ages 45-49 |
0.59 (0.18,1.0) |
| Ages 50-54 |
0.76 (0.33,1.19) |
| Ages 55-59 |
1.09 (0.62,1.56) |
| Ages 60-64 |
2.46 (1.86,3.06) |
| Ages 65-69 |
4.38 (3.46,5.3) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
3 (2,5) |
9 (7,12) |
29 (25,32) |
| CALIBER |
3 (2,3) |
10 (9,11) |
30 (28,32) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
5(1,13) |
10(5,16) |
28(21,37) |
| Low |
0(NaN,NaN) |
7(4,14) |
23(17,30) |
| Medium |
2(0,8) |
8(4,15) |
25(18,33) |
| High |
1(0,6) |
5(2,11) |
35(27,45) |
| Most deprived |
6(2,12) |
15(9,23) |
33(25,43) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
4(2,7) |
9(7,12) |
29(25,33) |
| Scotland |
0(NaN,NaN) |
11(5,20) |
29(20,40) |
| Wales |
0(NaN,NaN) |
5(1,16) |
28(17,43) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153969, Events=129
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
1.18 (0.74, 1.86) |
0.489 |
| BMI |
obese |
1.91 (1.2, 3.06) |
0.00685 |
| BMI |
underweight |
0 (0, Inf) |
0.995 |
| smoking |
previous |
1.29 (0.88, 1.87) |
0.189 |
| smoking |
current |
1.41 (0.81, 2.45) |
0.23 |
| hypertension |
yes |
1.93 (1.34, 2.77) |
0.000403 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1376 |
giant cell/temporal arteritis |
| 41202 |
Diagnoses - main ICD10 |
M31.5 |
Giant cell arteritis with polymyalgia rheumatica |
| 41202 |
Diagnoses - main ICD10 |
M31.6 |
Other giant cell arteritis |
| 41204 |
Diagnoses - secondary ICD10 |
M31.5 |
Giant cell arteritis with polymyalgia rheumatica |
| 41204 |
Diagnoses - secondary ICD10 |
M31.6 |
Other giant cell arteritis |
| 40001 |
Underlying (primary) cause of death: ICD10 |
M31.5 |
Giant cell arteritis with polymyalgia rheumatica |
| 40001 |
Underlying (primary) cause of death: ICD10 |
M31.6 |
Other giant cell arteritis |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
M31.5 |
Giant cell arteritis with polymyalgia rheumatica |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
M31.6 |
Other giant cell arteritis |
| 42040 |
GP clinical event records |
G755000 |
Cranial arteritis |
| 42040 |
GP clinical event records |
G755100 |
Temporal arteritis |
| 42040 |
GP clinical event records |
G755200 |
Horton’s disease |
| 42040 |
GP clinical event records |
G755.00 |
Giant cell arteritis |
| 42040 |
GP clinical event records |
G755z00 |
Giant cell arteritis NOS |
| 42040 |
GP clinical event records |
N200.00 |
Giant cell arteritis with polymyalgia rheumatica |
| 42040 |
GP clinical event records |
Nyu4100 |
[X]Other giant cell arteritis |
| 42040 |
GP clinical event records |
X705l |
Giant cell arteritis with polymyalgia rheumatica |