Gastro-oesophageal reflux disease

Metadata

Name	Gastro-oesophageal reflux disease (GORD)
Category	Digestive
Sex
Adult	Yes
UUID	f1f6f4d9-21ad-4234-ae3a-db2f9e42fa17
Definition	A chronic disorder characterized by reflux of the gastric and/or duodenal contents into the distal esophagus.

Ontologies

Disease Ontology (DOID)	DOID_8534
GWAS Catalogue	EFO_0003948
MeSH	D005764
SNOMED-CT	235595009
FinnGen	K11_REFLUX

Key Summary Statistics

Cases from any source

Total	74365
Female (%)	41037 (55%)
Male (%)	33328 (45%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	787.18 (769.06,805.31)
Male	818.96 (798.85,839.07)

Incidence stratified by sex

Female	77.16 (74.76,79.57)
Male	68.9 (66.41,71.39)

Incidence stratified by age

Ages 40-44	42.43 (38.26,46.6)
Ages 45-49	54.5 (50.41,58.59)
Ages 50-54	66.24 (62.04,70.44)
Ages 55-59	76.21 (72.09,80.32)
Ages 60-64	82.12 (78.42,85.81)
Ages 65-69	95.44 (90.83,100.05)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	585 (562,609)	835 (813,857)	1071 (1049,1092)
CALIBER	935 (926,943)	1255 (1245,	1614 (1601,

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	483(433,537)	774(727,824)	985(942,1031)
Low	492(442,547)	742(696,791)	1016(972,1061)
Medium	560(508,616)	842(793,893)	1072(1026,1120)
High	608(558,662)	830(782,881)	1111(1062,1162)
Most deprived	720(669,774)	982(930,1037)	1199(1146,1254)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	517(493,542)	754(730,778)	988(965,1011)
Scotland	642(573,717)	918(855,983)	1133(1070,1198)
Wales	1249(1125,1382)	1495(1392,1603)	1857(1757,1961)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153979, Events=141

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.41 (0.92, 2.17)	0.113
BMI	obese	1.52 (0.95, 2.43)	0.0832
BMI	underweight	0 (0, Inf)	0.992
smoking	previous	0.89 (0.63, 1.27)	0.531
smoking	current	0.83 (0.44, 1.56)	0.561
hypertension	yes	1.5 (1.06, 2.12)	0.0207

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1138	gastro-oesophageal reflux (gord) / gastric reflux
41202	Diagnoses - main ICD10	K21	Gastro-oesophageal reflux disease
41204	Diagnoses - secondary ICD10	K21	Gastro-oesophageal reflux disease
41200	Operative procedures - main OPCS4	G24	Antireflux operations
41200	Operative procedures - main OPCS4	G24.1	Antireflux fundoplication using thoracic approach
41200	Operative procedures - main OPCS4	G24.2	Antireflux operation using thoracic approach NEC
41200	Operative procedures - main OPCS4	G24.3	Antireflux fundoplication using abdominal approach
41200	Operative procedures - main OPCS4	G24.4	Antireflux gastropexy
41200	Operative procedures - main OPCS4	G24.5	Gastroplasty and antireflux procedure HFQ
41200	Operative procedures - main OPCS4	G24.6	Insertion of Angelchick prosthesis
41200	Operative procedures - main OPCS4	G24.8	Other specified antireflux operations
41200	Operative procedures - main OPCS4	G24.9	Unspecified antireflux operations
41200	Operative procedures - main OPCS4	G25	Revision of antireflux operations
41200	Operative procedures - main OPCS4	G25.1	Revision of fundoplication of stomach
41200	Operative procedures - main OPCS4	G25.2	Adjustment to Angelchick prosthesis
41200	Operative procedures - main OPCS4	G25.3	Removal of Angelchick prosthesis
41200	Operative procedures - main OPCS4	G25.8	Other specified revision of antireflux operations
41200	Operative procedures - main OPCS4	G25.9	Unspecified revision of antireflux operations
41210	Operative procedures - secondary OPCS4	G24	G24
41210	Operative procedures - secondary OPCS4	G24.1	G24.1
41210	Operative procedures - secondary OPCS4	G24.2	G24.2
41210	Operative procedures - secondary OPCS4	G24.3	G24.3
41210	Operative procedures - secondary OPCS4	G24.4	G24.4
41210	Operative procedures - secondary OPCS4	G24.5	G24.5
41210	Operative procedures - secondary OPCS4	G24.6	G24.6
41210	Operative procedures - secondary OPCS4	G24.8	G24.8
41210	Operative procedures - secondary OPCS4	G24.9	G24.9
41210	Operative procedures - secondary OPCS4	G25	G25
41210	Operative procedures - secondary OPCS4	G25.1	G25.1
41210	Operative procedures - secondary OPCS4	G25.2	G25.2
41210	Operative procedures - secondary OPCS4	G25.3	G25.3
41210	Operative procedures - secondary OPCS4	G25.8	G25.8
41210	Operative procedures - secondary OPCS4	G25.9	G25.9
40001	Underlying (primary) cause of death: ICD10	K21	Gastro-oesophageal reflux disease
40002	Contributory (secondary) causes of death: ICD10	K21	Gastro-oesophageal reflux disease
42040	GP clinical event records	171J.00	Reflux cough
42040	GP clinical event records	1957.00	Gastric reflux
42040	GP clinical event records	760L000	Antireflux fundoplication using thoracic approach
42040	GP clinical event records	760L100	Antireflux operation using thoracic approach NEC
42040	GP clinical event records	760L111	Antireflux procedure using thoracic approach NEC
42040	GP clinical event records	760L200	Antireflux fundoplication using abdominal approach
42040	GP clinical event records	760L300	Antireflux gastropexy
42040	GP clinical event records	760L311	Antireflux gastroplasty
42040	GP clinical event records	760L400	Antireflux procedure and gastroplasty HFQ
42040	GP clinical event records	760L.00	Antireflux operations
42040	GP clinical event records	760L.11	Oesophageal reflux operations
42040	GP clinical event records	760Ly00	Other specified antireflux operation
42040	GP clinical event records	760Lz00	Antireflux operation NOS
42040	GP clinical event records	760M.00	Revision of antireflux operations
42040	GP clinical event records	760Mz00	Revision of antireflux operation NOS
42040	GP clinical event records	J101100	Reflux oesophagitis
42040	GP clinical event records	J101111	Acid reflux
42040	GP clinical event records	J101112	Gastro-oesophageal reflux with oesophagitis
42040	GP clinical event records	J101113	Oesophageal reflux with oesophagitis
42040	GP clinical event records	J10y400	Oesopheal reflux without mention of oesophagitis
42040	GP clinical event records	J10y411	Oesophageal reflux
42040	GP clinical event records	J10y412	Gastro-oesophageal reflux
42040	GP clinical event records	J10y413	Acid reflux
42040	GP clinical event records	J10y500	Laryngopharyngeal reflux
42040	GP clinical event records	XaLCS	Reflux cough
42040	GP clinical event records	XE0CZ	Antireflux fundoplication using thoracic approach
42040	GP clinical event records	XaK99	Laryngopharyngeal reflux
42040	GP clinical event records	XE0Cb	Antireflux gastropexy
42040	GP clinical event records	XE0Ca	Antireflux fundoplication using abdominal approach
42040	GP clinical event records	XE0Ca	Antireflux fundoplication using abdominal approach