Gout

Metadata

Name	Gout (gout)
Category	Musculoskeletal
Sex
Adult	Yes
UUID	64939524-76c4-454c-86c6-d1a47d4957a3
Definition	A condition characterized by painful swelling of the joints, which is caused by deposition of urate crystals.

Ontologies

Disease Ontology (DOID)	DOID_13189
GWAS Catalogue	EFO_0004274
MeSH	D006073
SNOMED-CT	90560007
FinnGen	M13_GOUT

Key Summary Statistics

Cases from any source

Total	19778
Female (%)	3251 (16%)
Male (%)	16527 (84%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	65.07 (59.66,70.48)
Male	573.13 (556.09,590.18)

Incidence stratified by sex

Female	10.92 (10.06,11.79)
Male	46.17 (44.17,48.18)

Incidence stratified by age

Ages 40-44	14.48 (12.1,16.86)
Ages 45-49	16.62 (14.42,18.82)
Ages 50-54	19.65 (17.43,21.86)
Ages 55-59	24.87 (22.6,27.14)
Ages 60-64	32.9 (30.64,35.15)
Ages 65-69	38.04 (35.25,40.83)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	228 (213,244)	395 (379,411)	610 (594,627)
CALIBER	213 (209,217)	408 (402,414)	643 (635,651)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	226(191,265)	361(327,397)	576(542,611)
Low	237(200,277)	378(343,415)	566(532,601)
Medium	211(178,249)	403(367,441)	599(564,636)
High	231(199,266)	423(386,461)	615(577,654)
Most deprived	236(207,268)	408(373,444)	717(675,761)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	233(216,250)	405(387,423)	621(602,639)
Scotland	141(108,180)	255(221,292)	404(365,446)
Wales	320(257,395)	531(468,601)	809(742,880)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153520, Events=195

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.39 (0.98, 1.99)	0.068
BMI	obese	1.63 (1.11, 2.4)	0.0126
BMI	underweight	0 (0, Inf)	0.99
smoking	previous	1.5 (1.1, 2.03)	0.00988
smoking	current	1.45 (0.93, 2.27)	0.0986
hypertension	yes	1.38 (0.98, 1.93)	0.0624

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1466	gout
41202	Diagnoses - main ICD10	M10	Gout
41202	Diagnoses - main ICD10	M14.0	Gouty arthropathy due to enzyme defects and other inherited disorders
41204	Diagnoses - secondary ICD10	M10	Gout
41204	Diagnoses - secondary ICD10	M14.0	Gouty arthropathy due to enzyme defects and other inherited disorders
40001	Underlying (primary) cause of death: ICD10	M10	Gout
40001	Underlying (primary) cause of death: ICD10	M14.0	Gouty arthropathy due to enzyme defects and other inherited disorders
40002	Contributory (secondary) causes of death: ICD10	M10	Gout
40002	Contributory (secondary) causes of death: ICD10	M14.0	Gouty arthropathy due to enzyme defects and other inherited disorders
42040	GP clinical event records	1443.00	H/O: gout
42040	GP clinical event records	2D52.00	O/E - auricle of ear - tophi
42040	GP clinical event records	6691.00	Initial gout assessment
42040	GP clinical event records	6692.00	Follow-up gout assessment
42040	GP clinical event records	6693.00	Joints gout affected
42040	GP clinical event records	6695.00	Date gout treatment started
42040	GP clinical event records	6696.00	Date of last gout attack
42040	GP clinical event records	669..00	Gout monitoring
42040	GP clinical event records	6697.00	Gout associated problems
42040	GP clinical event records	669Z.00	Gout monitoring NOS
42040	GP clinical event records	C340.00	Gouty arthropathy
42040	GP clinical event records	C341.00	Gouty nephropathy
42040	GP clinical event records	C341z00	Gouty nephropathy NOS
42040	GP clinical event records	C342.00	Idiopathic gout
42040	GP clinical event records	C344.00	Drug-induced gout
42040	GP clinical event records	C345.00	Gout due to impairment of renal function
42040	GP clinical event records	C34..00	Gout
42040	GP clinical event records	C34y000	Gouty tophi of ear
42040	GP clinical event records	C34y100	Gouty tophi of heart
42040	GP clinical event records	C34y200	Gouty tophi of other sites
42040	GP clinical event records	C34y300	Gouty iritis
42040	GP clinical event records	C34y400	Gouty neuritis
42040	GP clinical event records	C34y500	Gouty tophi of hand
42040	GP clinical event records	C34y.00	Other specified gouty manifestation
42040	GP clinical event records	C34yz00	Other specified gouty manifestation NOS
42040	GP clinical event records	C34z.00	Gout NOS
42040	GP clinical event records	G557300	Gouty tophi of heart
42040	GP clinical event records	N023100	Gouty arthritis of the shoulder region
42040	GP clinical event records	N023200	Gouty arthritis of the upper arm
42040	GP clinical event records	N023300	Gouty arthritis of the forearm
42040	GP clinical event records	N023400	Gouty arthritis of the hand
42040	GP clinical event records	N023600	Gouty arthritis of the lower leg
42040	GP clinical event records	N023700	Gouty arthritis of the ankle and foot
42040	GP clinical event records	N023800	Gouty arthritis of toe
42040	GP clinical event records	N023.00	Gouty arthritis
42040	GP clinical event records	N023x00	Gouty arthritis of multiple sites
42040	GP clinical event records	N023y00	Gouty arthritis of other specified site
42040	GP clinical event records	N023z00	Gouty arthritis NOS
42040	GP clinical event records	Nyu1700	[X]Other secondary gout
42040	GP clinical event records	C34y1	Gouty tophi of heart
42040	GP clinical event records	XaNXG	Gouty arthritis of toe