Haemangioma, any site

Metadata

Name	Haemangioma, any site (haemangioma)
Category	Benign neoplasm or Carcinoma in situ
Sex
Adult	Yes
UUID	5d13053f-d2ff-41cb-91c0-1920b22456db
Definition	A benign vascular lesion characterized by the formation of capillary-sized or cavernous vascular channels.

Ontologies

Disease Ontology (DOID)	DOID_255
GWAS Catalogue	EFO_1000635
MeSH	D006391
SNOMED-CT	400210000
FinnGen	CD2_BENIGN_HEMANGIOMA

Key Summary Statistics

Cases from any source

Total	6000
Female (%)	3548 (59%)
Male (%)	2452 (41%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	123.65 (116.22,131.09)
Male	95.9 (88.75,103.04)

Incidence stratified by sex

Female	9.19 (8.4,9.98)
Male	7.71 (6.91,8.5)

Incidence stratified by age

Ages 40-44	6.92 (5.28,8.57)
Ages 45-49	8.64 (7.06,10.22)
Ages 50-54	7.38 (6.03,8.72)
Ages 55-59	8.44 (7.13,9.74)
Ages 60-64	9.28 (8.1,10.46)
Ages 65-69	9.2 (7.86,10.54)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	140 (129,152)	172 (162,182)	181 (173,190)
CALIBER	130 (127,133)	153 (150,157)	161 (157,165)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	172(143,205)	196(173,221)	196(176,216)
Low	152(125,183)	170(148,194)	180(161,199)
Medium	142(116,171)	197(174,223)	201(181,222)
High	131(109,157)	166(145,189)	164(145,184)
Most deprived	114(95,137)	131(112,151)	162(142,183)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	134(122,147)	162(152,174)	183(173,193)
Scotland	128(99,163)	165(139,193)	142(121,167)
Wales	217(168,276)	273(230,321)	228(194,266)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153561, Events=310

Factor	Level	Hazard Ratio	P value
BMI	overweight	0.89 (0.68, 1.17)	0.406
BMI	obese	1.13 (0.84, 1.51)	0.416
BMI	underweight	0 (0, Inf)	0.987
smoking	previous	0.95 (0.75, 1.22)	0.699
smoking	current	1.05 (0.72, 1.55)	0.789
hypertension	yes	1.12 (0.87, 1.45)	0.386

Definition

UK Biobank field id	Description	Code	Value
41202	Diagnoses - main ICD10	D18.0	Haemangioma, any site
41204	Diagnoses - secondary ICD10	D18.0	Haemangioma, any site
40001	Underlying (primary) cause of death: ICD10	D18.0	Haemangioma, any site
40002	Contributory (secondary) causes of death: ICD10	D18.0	Haemangioma, any site
42040	GP clinical event records	2F25.00	O/E - capilliary naevi present
42040	GP clinical event records	7A6G600	Excision of haemangioma
42040	GP clinical event records	B7J0000	Haemangioma of unspecified site
42040	GP clinical event records	B7J0100	Haemangioma of skin and subcutaneous tissue
42040	GP clinical event records	B7J0111	Skin haemangioma
42040	GP clinical event records	B7J0112	Subcutaneous haemangioma
42040	GP clinical event records	B7J0200	Haemangioma of intracranial structures
42040	GP clinical event records	B7J0300	Haemangioma of retina
42040	GP clinical event records	B7J0400	Haemangioma of intra-abdominal structures
42040	GP clinical event records	B7J0.00	Haemangioma
42040	GP clinical event records	B7J0.11	Glomus tumour
42040	GP clinical event records	B7J0z00	Haemangioma NOS
42040	GP clinical event records	B7J..00	Haemangiomas and lymphangiomas of any site
42040	GP clinical event records	B7Jz.00	Haemangioma or lymphangioma NOS
42040	GP clinical event records	BBd7.00	[M]Haemangioblastic meningioma
42040	GP clinical event records	BBd8.00	[M]Haemangiopericytic meningioma
42040	GP clinical event records	BBDC.00	[M]Glomus tumour
42040	GP clinical event records	BBGK.13	[M]Sclerosing haemangioma
42040	GP clinical event records	BBT0.00	[M]Haemangioma NOS
42040	GP clinical event records	BBT2.00	[M]Cavernous haemangioma
42040	GP clinical event records	BBT3.00	[M]Venous haemangioma
42040	GP clinical event records	BBT4.00	[M]Racemose haemangioma
42040	GP clinical event records	BBT4.11	[M]Arteriovenous haemangioma
42040	GP clinical event records	BBT7000	[M]Haemangioendothelioma, benign
42040	GP clinical event records	BBT8.00	[M]Capillary haemangioma
42040	GP clinical event records	BBT8.11	[M]Haemangioma simplex
42040	GP clinical event records	BBT8.12	[M]Infantile haemangioma
42040	GP clinical event records	BBT8.13	[M]Juvenile haemangioma
42040	GP clinical event records	BBT8.14	[M]Plexiform haemangioma
42040	GP clinical event records	BBT9.00	[M]Intramuscular haemangioma
42040	GP clinical event records	BBT..11	[M]Haemangiomatous tumours
42040	GP clinical event records	BBTC.00	[M]Verrucous keratotic haemangioma
42040	GP clinical event records	BBTD000	[M]Haemangiopericytoma, benign
42040	GP clinical event records	BBTF.00	[M]Haemangioblastoma
42040	GP clinical event records	BBTG.00	[M]Epithelioid haemangioma
42040	GP clinical event records	BBTH.00	[M]Histiocytoid haemangioma
42040	GP clinical event records	G771200	Campbell de Morgan’s spots
42040	GP clinical event records	PG42000	Multiple enchondromata with haemangioma
42040	GP clinical event records	PG42011	Kast’s syndrome
42040	GP clinical event records	PG42012	Maffuci’s syndrome
42040	GP clinical event records	PH31200	Strawberry naevus
42040	GP clinical event records	XaC0g	Excision of haemangioma
42040	GP clinical event records	XE2vc	Haemangiomas and lymphangiomas of any site
42040	GP clinical event records	XE2vd	Haemangioma of skin and subcutaneous tissue
42040	GP clinical event records	XE1wE	Haemangioma
40006	Type of cancer: ICD10	D18.0	Haemangioma, any site