Metadata

Name Hidradenitis suppurativa (hidradenitis)
Category Skin
Sex
Adult Yes
UUID e189b077-cb53-49a4-96dd-a75feb79e8be
Definition Hidradenitis suppurativa a common (though rarely diagnosed), chronic skin disease characterized by clusters of abscesses or subcutaneous boil-like “infections” (oftentimes free of actual bacteria) that most commonly affects apocrine sweat gland bearing areas, such as the underarms, under the breasts, inner thighs, groin and buttocks.The disease is not contagious. There are indications that it is hereditary among certain ethnic groups and autoimmune in nature. Onset is most common in the late teens and early 20’s.

Ontologies

Disease Ontology (DOID) DOID_2282
GWAS Catalogue EFO_1000710
MeSH D016575
SNOMED-CT 69741000
FinnGen L12_HIDRADENITISSUP

Key Summary Statistics

Cases from any source

Total 496
Female (%) 357 (72%)
Male (%) 139 (28%)

Year first recorded

hidradenitis year of first event

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Cross-sourced hidradenitis cases

Incidence & prevalence

Sex and age-stratified incidence and prevalence of hidradenitis

Baseline prevalence stratified by sex

Female 10.84 (8.63,13.06)
Male 6.02 (4.22,7.82)

Incidence stratified by sex

Female 0.47 (0.3,0.65)
Male 0.38 (0.2,0.55)

Incidence stratified by age

Ages 40-44 1.21 (0.52,1.89)
Ages 45-49 0.59 (0.18,1.01)
Ages 50-54 0.38 (0.08,0.68)
Ages 55-59 0.31 (0.06,0.56)
Ages 60-64 0.31 (0.09,0.52)
Ages 65-69 0.25 (0.03,0.47)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

CALIBER and UKB hidradenitis prevalence comparison for multiple age groups

Population Ages 40-49 Ages 50-59 Ages 60-69
UK Biobank 24 (19,29) 16 (13,19) 9 (7,11)
CALIBER 48 (46,49) 37 (35,39) 20 (19,22)

Stratified by age and Townsend deprivation status

Deprivation status Ages 40-49 Ages 50-59 Ages 60-69
Least deprived 22(12,35) 13(7,21) 8(5,13)
Low 12(5,23) 13(7,20) 7(4,12)
Medium 18(10,31) 18(12,27) 10(6,16)
High 21(13,33) 19(13,27) 7(4,12)
Most deprived 40(29,54) 17(11,25) 15(10,23)

Stratified by age and country

Country Ages 40-49 Ages 50-59 Ages 60-69
England 18(14,23) 12(9,15) 8(6,11)
Scotland 45(29,67) 20(12,31) 11(6,19)
Wales 47(26,77) 50(34,72) 17(9,29)

Definition

UK Biobank field id Description Code Value
41202 Diagnoses - main ICD10 L73.2 Hidradenitis suppurativa
41204 Diagnoses - secondary ICD10 L73.2 Hidradenitis suppurativa
40001 Underlying (primary) cause of death: ICD10 L73.2 Hidradenitis suppurativa
40002 Contributory (secondary) causes of death: ICD10 L73.2 Hidradenitis suppurativa
42040 GP clinical event records M25y100 Hidradenitis
42040 GP clinical event records M25y111 Hidradenitis suppurativa
42040 GP clinical event records XE1BM Hidradenitis