HIV

Metadata

Name	HIV (hiv)
Category	Infections
Sex
Adult	Yes
UUID	b210f925-7cca-4ea8-8f40-230e90277cff
Definition	Human immunodeficiency virus.

Ontologies

Disease Ontology (DOID)	DOID_526
GWAS Catalogue	EFO_0000764
MeSH	D006678
SNOMED-CT	86406008
FinnGen	AB1_HIV

Key Summary Statistics

Cases from any source

Total	567
Female (%)	93 (16%)
Male (%)	474 (84%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	1.89 (0.96,2.81)
Male	15.54 (12.65,18.43)

Incidence stratified by sex

Female	0.07 (0.0,0.14)
Male	0.51 (0.3,0.71)

Incidence stratified by age

Ages 40-44	0.6 (0.12,1.09)
Ages 45-49	0.45 (0.09,0.8)
Ages 50-54	0.38 (0.08,0.68)
Ages 55-59	0.26 (0.03,0.49)
Ages 60-64	0.12 (-0.02,0.25)
Ages 65-69	0.1 (-0.04,0.24)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	22 (17,27)	12 (9,15)	3 (2,4)
CALIBER	21 (20,22)	12 (11,13)	5 (4,6)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	9(3,19)	2(0,6)	0(NaN,NaN)
Low	5(1,14)	5(2,11)	3(1,6)
Medium	13(6,25)	6(2,12)	2(1,6)
High	18(10,30)	11(6,19)	3(1,7)
Most deprived	52(39,68)	33(23,44)	9(5,15)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	24(19,30)	13(10,16)	3(2,5)
Scotland	9(2,22)	11(5,21)	3(1,9)
Wales	16(5,39)	2(0,12)	2(0,9)

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1439	hiv/aids
41202	Diagnoses - main ICD10	B20	Human immunodeficiency virus [HIV] disease resulting in infectious and parasitic diseases
41202	Diagnoses - main ICD10	B21	Human immunodeficiency virus [HIV] disease resulting in malignant neoplasms
41202	Diagnoses - main ICD10	B22	Human immunodeficiency virus [HIV] disease resulting in other specified diseases
41202	Diagnoses - main ICD10	B23	Human immunodeficiency virus [HIV] disease resulting in other conditions
41202	Diagnoses - main ICD10	B24	Unspecified human immunodeficiency virus [HIV] disease
41202	Diagnoses - main ICD10	F02.4	Dementia in human immunodeficiency virus [HIV] disease
41202	Diagnoses - main ICD10	R75	Laboratory evidence of human immunodeficiency virus [HIV]
41202	Diagnoses - main ICD10	Z21	Asymptomatic human immunodeficiency virus [HIV] infection status
41204	Diagnoses - secondary ICD10	B20	Human immunodeficiency virus [HIV] disease resulting in infectious and parasitic diseases
41204	Diagnoses - secondary ICD10	B21	Human immunodeficiency virus [HIV] disease resulting in malignant neoplasms
41204	Diagnoses - secondary ICD10	B22	Human immunodeficiency virus [HIV] disease resulting in other specified diseases
41204	Diagnoses - secondary ICD10	B23	Human immunodeficiency virus [HIV] disease resulting in other conditions
41204	Diagnoses - secondary ICD10	B24	Unspecified human immunodeficiency virus [HIV] disease
41204	Diagnoses - secondary ICD10	F02.4	Dementia in human immunodeficiency virus [HIV] disease
41204	Diagnoses - secondary ICD10	R75	Laboratory evidence of human immunodeficiency virus [HIV]
41204	Diagnoses - secondary ICD10	Z21	Asymptomatic human immunodeficiency virus [HIV] infection status
40001	Underlying (primary) cause of death: ICD10	B20	Human immunodeficiency virus [HIV] disease resulting in infectious and parasitic diseases
40001	Underlying (primary) cause of death: ICD10	B21	Human immunodeficiency virus [HIV] disease resulting in malignant neoplasms
40001	Underlying (primary) cause of death: ICD10	B22	Human immunodeficiency virus [HIV] disease resulting in other specified diseases
40001	Underlying (primary) cause of death: ICD10	B23	Human immunodeficiency virus [HIV] disease resulting in other conditions
40001	Underlying (primary) cause of death: ICD10	B24	Unspecified human immunodeficiency virus [HIV] disease
40001	Underlying (primary) cause of death: ICD10	F02.4	Dementia in human immunodeficiency virus [HIV] disease
40001	Underlying (primary) cause of death: ICD10	R75	Laboratory evidence of human immunodeficiency virus [HIV]
40001	Underlying (primary) cause of death: ICD10	Z21	Asymptomatic human immunodeficiency virus [HIV] infection status
40002	Contributory (secondary) causes of death: ICD10	B20	Human immunodeficiency virus [HIV] disease resulting in infectious and parasitic diseases
40002	Contributory (secondary) causes of death: ICD10	B21	Human immunodeficiency virus [HIV] disease resulting in malignant neoplasms
40002	Contributory (secondary) causes of death: ICD10	B22	Human immunodeficiency virus [HIV] disease resulting in other specified diseases
40002	Contributory (secondary) causes of death: ICD10	B23	Human immunodeficiency virus [HIV] disease resulting in other conditions
40002	Contributory (secondary) causes of death: ICD10	B24	Unspecified human immunodeficiency virus [HIV] disease
40002	Contributory (secondary) causes of death: ICD10	F02.4	Dementia in human immunodeficiency virus [HIV] disease
40002	Contributory (secondary) causes of death: ICD10	R75	Laboratory evidence of human immunodeficiency virus [HIV]
40002	Contributory (secondary) causes of death: ICD10	Z21	Asymptomatic human immunodeficiency virus [HIV] infection status
42040	GP clinical event records	43C3.11	HIV positive
42040	GP clinical event records	4J34.00	HIV viral load
42040	GP clinical event records	4J3F.00	Human immunodeficiency virus viral load by log rank
42040	GP clinical event records	65QA.00	AIDS carrier
42040	GP clinical event records	65VE.00	Notification of AIDS
42040	GP clinical event records	66j0.00	Human immunodeficiency virus annual review
42040	GP clinical event records	66j..00	Human immunodeficiency virus monitoring
42040	GP clinical event records	9kl..00	HIV pos gen health check serv declind - enhanc service admin
42040	GP clinical event records	A788000	Acute human immunodeficiency virus infection
42040	GP clinical event records	A788100	Asymptomatic human immunodeficiency virus infection
42040	GP clinical event records	A788200	HIV infection with persistent generalised lymphadenopathy
42040	GP clinical event records	A788300	Human immunodeficiency virus with constitutional disease
42040	GP clinical event records	A788400	Human immunodeficiency virus with neurological disease
42040	GP clinical event records	A788500	Human immunodeficiency virus with secondary infection
42040	GP clinical event records	A788600	Human immunodeficiency virus with secondary cancers
42040	GP clinical event records	A788.00	Acquired immune deficiency syndrome
42040	GP clinical event records	A788.11	Human immunodeficiency virus infection
42040	GP clinical event records	A788U00	HIV disease result/haematological+immunologic abnorms,NEC
42040	GP clinical event records	A788W00	HIV disease resulting in unspecified malignant neoplasm
42040	GP clinical event records	A788X00	HIV disease resulting/unspcf infectious+parasitic disease
42040	GP clinical event records	A788y00	Human immunodeficiency virus with other clinical findings
42040	GP clinical event records	A788z00	Acquired human immunodeficiency virus infection syndrome NOS
42040	GP clinical event records	A789000	HIV disease resulting in mycobacterial infection
42040	GP clinical event records	A789100	HIV disease resulting in cytomegaloviral disease
42040	GP clinical event records	A789200	HIV disease resulting in candidiasis
42040	GP clinical event records	A789300	HIV disease resulting in Pneumocystis carinii pneumonia
42040	GP clinical event records	A789311	HIV disease resulting in Pneumocystis jirovecii pneumonia
42040	GP clinical event records	A789400	HIV disease resulting in multiple infections
42040	GP clinical event records	A789500	HIV disease resulting in Kaposi’s sarcoma
42040	GP clinical event records	A789511	HIV disease resulting in Kaposi sarcoma
42040	GP clinical event records	A789600	HIV disease resulting in Burkitt’s lymphoma
42040	GP clinical event records	A789700	HIV dis resulting oth types of non-Hodgkin’s lymphoma
42040	GP clinical event records	A789800	HIV disease resulting in multiple malignant neoplasms
42040	GP clinical event records	A789900	HIV disease resulting in lymphoid interstitial pneumonitis
42040	GP clinical event records	A789.00	Human immunodef virus resulting in other disease
42040	GP clinical event records	A789A00	HIV disease resulting in wasting syndrome
42040	GP clinical event records	A789X00	HIV dis reslt/oth mal neopl/lymph,h’matopoetc+reltd tissu
42040	GP clinical event records	AyuC100	[X]HIV disease resulting in other viral infections
42040	GP clinical event records	AyuC300	[X]HIV disease resulting in multiple infections
42040	GP clinical event records	AyuC400	[X]HIV disease resulting/other infectious+parasitic diseases
42040	GP clinical event records	AyuC600	[X]HIV disease resulting in other non-Hodgkin’s lymphoma
42040	GP clinical event records	AyuC.00	[X]Human immunodeficiency virus disease
42040	GP clinical event records	AyuCB00	[X]HIV disease result/haematological+immunologic abnorms,NEC
42040	GP clinical event records	AyuCC00	[X]HIV disease resulting in other specified conditions
42040	GP clinical event records	AyuCD00	[X]Unspecified human immunodeficiency virus [HIV] disease
42040	GP clinical event records	Eu02400	[X]Dementia in human immunodef virus [HIV] disease
42040	GP clinical event records	R109.00	[D]Laboratory evidence of human immunodeficiency virus [HIV]
42040	GP clinical event records	ZV01A00	[V]Asymptomatic human immunodeficency virus infection status
42040	GP clinical event records	XaO9K	Human immunodeficiency virus viral load by log rank
42040	GP clinical event records	XaFuL	HIV viral load
42040	GP clinical event records	XE0RX	Acquired immune deficiency syndrome
42040	GP clinical event records	XaQOu	Human immunodeficiency virus annual review
42040	GP clinical event records	XaQOt	Human immunodeficiency virus monitoring