| Name |
Hypertrophic Cardiomyopathy (hocm) |
| Category |
Cardiovascular |
| Sex |
|
| Adult |
Yes |
| UUID |
7dbbc676-2c2a-4c9a-9063-16a4f5ac35a3 |
| Definition |
Hypertrophic cardiomyopathy (HCM) is an inherited disease of tje heart muscle, where the muscle wall of the heart becomes thickened. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
724 |
| Female (%) |
255 (35%) |
| Male (%) |
469 (65%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
3.65 (2.37,4.94) |
| Male |
7.56 (5.54,9.58) |
Incidence stratified by sex
| Female |
0.61 (0.41,0.82) |
| Male |
0.95 (0.67,1.22) |
Incidence stratified by age
| Ages 40-44 |
0.2 (-0.08,0.48) |
| Ages 45-49 |
0.67 (0.23,1.1) |
| Ages 50-54 |
0.32 (0.04,0.59) |
| Ages 55-59 |
0.94 (0.5,1.37) |
| Ages 60-64 |
0.84 (0.49,1.2) |
| Ages 65-69 |
1.21 (0.72,1.69) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
6 (4,9) |
9 (7,12) |
9 (7,11) |
| CALIBER |
4 (4,5) |
8 (7,9) |
11 (10,12) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
4(1,13) |
8(4,15) |
8(4,12) |
| Low |
2(0,9) |
7(3,13) |
12(7,18) |
| Medium |
7(2,17) |
5(2,11) |
8(4,13) |
| High |
6(2,13) |
10(5,17) |
8(5,14) |
| Most deprived |
9(4,17) |
16(9,24) |
11(6,17) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
6(4,9) |
9(6,12) |
10(7,12) |
| Scotland |
5(1,17) |
11(5,21) |
8(3,16) |
| Wales |
7(1,27) |
11(4,25) |
7(2,17) |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1588 |
hypertrophic cardiomyopathy (hcm / hocm) |
| 41202 |
Diagnoses - main ICD10 |
I42.1 |
Obstructive hypertrophic cardiomyopathy |
| 41202 |
Diagnoses - main ICD10 |
I42.2 |
Other hypertrophic cardiomyopathy |
| 41204 |
Diagnoses - secondary ICD10 |
I42.1 |
Obstructive hypertrophic cardiomyopathy |
| 41204 |
Diagnoses - secondary ICD10 |
I42.2 |
Other hypertrophic cardiomyopathy |
| 40001 |
Underlying (primary) cause of death: ICD10 |
I42.1 |
Obstructive hypertrophic cardiomyopathy |
| 40001 |
Underlying (primary) cause of death: ICD10 |
I42.2 |
Other hypertrophic cardiomyopathy |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
I42.1 |
Obstructive hypertrophic cardiomyopathy |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
I42.2 |
Other hypertrophic cardiomyopathy |
| 42040 |
GP clinical event records |
G551.00 |
Hypertrophic obstructive cardiomyopathy |
| 42040 |
GP clinical event records |
G554300 |
Hypertrophic non-obstructive cardiomyopathy |
| 42040 |
GP clinical event records |
Gyu5M00 |
[X]Other hypertrophic cardiomyopathy |