Hodgkin Lymphoma

Metadata

Name	Hodgkin Lymphoma (hodgkins)
Category	Cancers
Sex
Adult	Yes
UUID	f5d1cc7f-b61a-433a-8b3d-303b6e17c503
Definition	A viral infectious disease that results in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles.

Ontologies

Disease Ontology (DOID)	DOID_8567
GWAS Catalogue	EFO_0000183
MeSH	D006689
SNOMED-CT	14537002
FinnGen	C_HODGKIN_LYMPHOMA

Key Summary Statistics

Cases from any source

Total	794
Female (%)	369 (46%)
Male (%)	425 (54%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	9.67 (7.57,11.76)
Male	10.92 (8.5,13.34)

Incidence stratified by sex

Female	0.46 (0.28,0.63)
Male	0.61 (0.39,0.83)

Incidence stratified by age

Ages 40-44	0.0 (0.0,0.0)
Ages 45-49	0.45 (0.09,0.8)
Ages 50-54	0.63 (0.24,1.03)
Ages 55-59	0.42 (0.13,0.7)
Ages 60-64	0.58 (0.28,0.87)
Ages 65-69	0.8 (0.41,1.2)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	13 (10,17)	12 (9,15)	12 (10,15)
CALIBER	9 (9,10)	9 (9,10)	12 (11,13)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	15(8,28)	12(7,20)	16(11,23)
Low	12(5,23)	15(9,24)	14(10,21)
Medium	12(5,22)	10(5,17)	7(4,12)
High	13(7,24)	10(5,17)	9(5,15)
Most deprived	12(7,21)	12(7,19)	14(8,21)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	13(10,18)	12(9,16)	13(10,16)
Scotland	14(5,29)	13(7,22)	8(4,16)
Wales	7(1,27)	5(1,16)	9(3,19)

Definition

UK Biobank field id	Description	Code	Value
20001	Cancer code, self-reported	1052	hodgkins lymphoma / hodgkins disease
41202	Diagnoses - main ICD10	C81	Hodgkin lymphoma
41204	Diagnoses - secondary ICD10	C81	Hodgkin lymphoma
40001	Underlying (primary) cause of death: ICD10	C81	Hodgkin lymphoma
40002	Contributory (secondary) causes of death: ICD10	C81	Hodgkin lymphoma
42040	GP clinical event records	B610100	Hodgkin’s paragranuloma of lymph nodes of head, face, neck
42040	GP clinical event records	B610300	Hodgkin’s paragranuloma of intra-abdominal lymph nodes
42040	GP clinical event records	B610.00	Hodgkin’s paragranuloma
42040	GP clinical event records	B611100	Hodgkin’s granuloma of lymph nodes of head, face and neck
42040	GP clinical event records	B611.00	Hodgkin’s granuloma
42040	GP clinical event records	B612400	Hodgkin’s sarcoma of lymph nodes of axilla and upper limb
42040	GP clinical event records	B612.00	Hodgkin’s sarcoma
42040	GP clinical event records	B613000	Hodgkin’s, lymphocytic-histiocytic predominance unspec site
42040	GP clinical event records	B613100	Hodgkin’s, lymphocytic-histiocytic pred of head, face, neck
42040	GP clinical event records	B613200	Hodgkin’s, lymphocytic-histiocytic pred intrathoracic nodes
42040	GP clinical event records	B613300	Hodgkin’s, lymphocytic-histiocytic pred intra-abdominal node
42040	GP clinical event records	B613500	Hodgkin’s, lymphocytic-histiocytic pred inguinal and leg
42040	GP clinical event records	B613600	Hodgkin’s, lymphocytic-histiocytic pred intrapelvic nodes
42040	GP clinical event records	B613700	Hodgkin’s, lymphocytic-histiocytic predominance of spleen
42040	GP clinical event records	B613800	Hodgkin’s, lymphocytic-histiocytic pred of multiple sites
42040	GP clinical event records	B613.00	Hodgkin’s disease, lymphocytic-histiocytic predominance
42040	GP clinical event records	B613z00	Hodgkin’s, lymphocytic-histiocytic predominance NOS
42040	GP clinical event records	B614000	Hodgkin’s disease, nodular sclerosis of unspecified site
42040	GP clinical event records	B614100	Hodgkin’s nodular sclerosis of head, face and neck
42040	GP clinical event records	B614200	Hodgkin’s nodular sclerosis of intrathoracic lymph nodes
42040	GP clinical event records	B614300	Hodgkin’s nodular sclerosis of intra-abdominal lymph nodes
42040	GP clinical event records	B614400	Hodgkin’s nodular sclerosis of lymph nodes of axilla and arm
42040	GP clinical event records	B614700	Hodgkin’s disease, nodular sclerosis of spleen
42040	GP clinical event records	B614800	Hodgkin’s nodular sclerosis of lymph nodes of multiple sites
42040	GP clinical event records	B614.00	Hodgkin’s disease, nodular sclerosis
42040	GP clinical event records	B614z00	Hodgkin’s disease, nodular sclerosis NOS
42040	GP clinical event records	B615000	Hodgkin’s disease, mixed cellularity of unspecified site
42040	GP clinical event records	B615100	Hodgkin’s mixed cellularity of lymph nodes head, face, neck
42040	GP clinical event records	B615200	Hodgkin’s mixed cellularity of intrathoracic lymph nodes
42040	GP clinical event records	B615500	Hodgkin’s mixed cellularity of lymph nodes inguinal and leg
42040	GP clinical event records	B615.00	Hodgkin’s disease, mixed cellularity
42040	GP clinical event records	B615z00	Hodgkin’s disease, mixed cellularity NOS
42040	GP clinical event records	B616000	Hodgkin’s lymphocytic depletion of unspecified site
42040	GP clinical event records	B616400	Hodgkin’s lymphocytic depletion lymph nodes axilla and arm
42040	GP clinical event records	B616500	Hodgkin’s lymphocytic depletion lymph nodes inguinal and leg
42040	GP clinical event records	B616700	Hodgkin’s disease, lymphocytic depletion of spleen
42040	GP clinical event records	B616800	Hodgkin’s lymphocytic depletion lymph nodes multiple sites
42040	GP clinical event records	B616.00	Hodgkin’s disease, lymphocytic depletion
42040	GP clinical event records	B616z00	Hodgkin’s disease, lymphocytic depletion NOS
42040	GP clinical event records	B617.00	Nodular lymphocyte predominant Hodgkin lymphoma
42040	GP clinical event records	B618.00	Nodular sclerosis classical Hodgkin lymphoma
42040	GP clinical event records	B619.00	Mixed cellularity classical Hodgkin lymphoma
42040	GP clinical event records	B61..00	Hodgkin’s disease
42040	GP clinical event records	B61..11	Hodgkin lymphoma
42040	GP clinical event records	B61B.00	Lymphocyte-rich classical Hodgkin lymphoma
42040	GP clinical event records	B61C.00	Other classical Hodgkin lymphoma
42040	GP clinical event records	B61z000	Hodgkin’s disease NOS, unspecified site
42040	GP clinical event records	B61z100	Hodgkin’s disease NOS of lymph nodes of head, face and neck
42040	GP clinical event records	B61z200	Hodgkin’s disease NOS of intrathoracic lymph nodes
42040	GP clinical event records	B61z300	Hodgkin’s disease NOS of intra-abdominal lymph nodes
42040	GP clinical event records	B61z400	Hodgkin’s disease NOS of lymph nodes of axilla and arm
42040	GP clinical event records	B61z500	Hodgkin’s disease NOS of lymph nodes inguinal region and leg
42040	GP clinical event records	B61z700	Hodgkin’s disease NOS of spleen
42040	GP clinical event records	B61z800	Hodgkin’s disease NOS of lymph nodes of multiple sites
42040	GP clinical event records	B61z.00	Hodgkin’s disease NOS
42040	GP clinical event records	B61z.11	Hodgkin lymphoma NOS
42040	GP clinical event records	B61zz00	Hodgkin’s disease NOS
42040	GP clinical event records	BBj0.00	[M]Hodgkin’s disease NOS
42040	GP clinical event records	BBj1000	[M]Hodgkin,s disease, lymphocytic predominance, diffuse
42040	GP clinical event records	BBj1100	[M]Hodgkin,s disease, lymphocytic predominance, nodular
42040	GP clinical event records	BBj1.00	[M]Hodgkin’s disease, lymphocytic predominance
42040	GP clinical event records	BBj2.00	[M]Hodgkin’s disease, mixed cellularity
42040	GP clinical event records	BBj4.00	[M]Hodgkin’s disease,lymphocytic depletion,diffuse fibrosis
42040	GP clinical event records	BBj6000	[M]Hodgkin,s disease, nodular sclerosis, lymphocytic predom
42040	GP clinical event records	BBj6100	[M]Hodgkin,s disease, nodular sclerosis, mixed cellularity
42040	GP clinical event records	BBj6200	[M]Hodgkin,s disease, nodular sclerosis, lymphocytic deplet
42040	GP clinical event records	BBj6.00	[M]Hodgkin’s disease, nodular sclerosis NOS
42040	GP clinical event records	BBj7.00	[M]Hodgkin’s disease, nodular sclerosis, cellular phase
42040	GP clinical event records	BBj9.00	[M]Hodgkin’s granuloma
42040	GP clinical event records	BBj..00	[M]Hodgkin’s disease
42040	GP clinical event records	BBjz.00	[M]Hodgkin’s disease NOS
42040	GP clinical event records	ByuD000	[X]Other Hodgkin’s disease
42040	GP clinical event records	ZV10711	[V]Personal history of Hodgkin’s disease
42040	GP clinical event records	B61z.	Hodgkin’s disease NOS
42040	GP clinical event records	B613.	Lymphocyte-rich classical Hodgkin lymphoma
42040	GP clinical event records	XaC2n	[M]Hodgkin’s disease NOS
42040	GP clinical event records	XaC2n	[M]Hodgkin’s disease NOS
40006	Type of cancer: ICD10	C81	Hodgkin lymphoma