Hydrocoele (incl infected)

Metadata

Name	Hydrocoele (incl infected) (hydrocele)
Category	Genitourinary
Sex
Adult	Yes
UUID	08bc2140-29d7-4630-92a3-8f3f63faa031
Definition	Accumulation of serous fluid in a body cavity.

Ontologies

Disease Ontology (DOID)	DOID_9912
MeSH	D006848
SNOMED-CT	386152007
FinnGen	N14_HYDROCELE

Key Summary Statistics

Cases from any source

Total	3570
Female (%)	0 (0%)
Male (%)	3570 (100%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	0.0 (0.0,0.0)
Male	129.63 (121.34,137.93)

Incidence stratified by sex

Female	0.0 (0.0,0.0)
Male	9.41 (8.53,10.29)

Incidence stratified by age

Ages 40-44	1.52 (0.75,2.28)
Ages 45-49	3.13 (2.18,4.08)
Ages 50-54	3.31 (2.41,4.21)
Ages 55-59	4.07 (3.17,4.98)
Ages 60-64	5.07 (4.21,5.94)
Ages 65-69	6.18 (5.08,7.28)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	71 (62,80)	72 (65,79)	114 (107,121)
CALIBER	131 (127,135)	156 (151,161)	222 (216,229)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	81(61,106)	65(51,82)	107(93,124)
Low	85(64,111)	88(71,107)	108(94,125)
Medium	74(55,97)	73(58,90)	120(104,137)
High	66(49,86)	67(53,83)	122(106,141)
Most deprived	56(43,73)	69(55,85)	113(96,131)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	72(63,83)	74(66,82)	117(109,125)
Scotland	76(52,107)	70(53,92)	99(80,121)
Wales	41(20,73)	58(38,85)	104(81,132)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153321, Events=259

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.47 (1.07, 2.01)	0.0165
BMI	obese	2.46 (1.81, 3.35)	1.19e-08
BMI	underweight	0 (0, Inf)	0.998
smoking	previous	1.06 (0.81, 1.39)	0.676
smoking	current	0.75 (0.46, 1.22)	0.25
hypertension	yes	0.83 (0.58, 1.19)	0.31

Definition

UK Biobank field id	Description	Code	Value
41202	Diagnoses - main ICD10	N43.0	Encysted hydrocele
41202	Diagnoses - main ICD10	N43.1	Infected hydrocele
41202	Diagnoses - main ICD10	N43.2	Other hydrocele
41202	Diagnoses - main ICD10	N43.3	Hydrocele, unspecified
41202	Diagnoses - main ICD10	P83.5	Congenital hydrocele
41204	Diagnoses - secondary ICD10	N43.0	Encysted hydrocele
41204	Diagnoses - secondary ICD10	N43.1	Infected hydrocele
41204	Diagnoses - secondary ICD10	N43.2	Other hydrocele
41204	Diagnoses - secondary ICD10	N43.3	Hydrocele, unspecified
41204	Diagnoses - secondary ICD10	P83.5	Congenital hydrocele
40001	Underlying (primary) cause of death: ICD10	N43.0	Encysted hydrocele
40001	Underlying (primary) cause of death: ICD10	N43.1	Infected hydrocele
40001	Underlying (primary) cause of death: ICD10	N43.2	Other hydrocele
40001	Underlying (primary) cause of death: ICD10	N43.3	Hydrocele, unspecified
40001	Underlying (primary) cause of death: ICD10	P83.5	Congenital hydrocele
40002	Contributory (secondary) causes of death: ICD10	N43.0	Encysted hydrocele
40002	Contributory (secondary) causes of death: ICD10	N43.1	Infected hydrocele
40002	Contributory (secondary) causes of death: ICD10	N43.2	Other hydrocele
40002	Contributory (secondary) causes of death: ICD10	N43.3	Hydrocele, unspecified
40002	Contributory (secondary) causes of death: ICD10	P83.5	Congenital hydrocele
42040	GP clinical event records	7C08000	Excision of hydrocele sac
42040	GP clinical event records	7C08100	Injection sclerotherapy of hydrocele
42040	GP clinical event records	7C08200	Drainage of hydrocele
42040	GP clinical event records	7C08300	Jaboulay’s eversion of hydrocele
42040	GP clinical event records	7C08311	Eversion of hydrocele
42040	GP clinical event records	7C08400	Lord’s plication of hydrocele
42040	GP clinical event records	7C08500	Diagnostic aspiration of hydrocele
42040	GP clinical event records	7C08600	Correction of hydrocele of infancy
42040	GP clinical event records	7C08700	Other aspiration of hydrocele
42040	GP clinical event records	7C08711	Other aspiration of hydrocele sac
42040	GP clinical event records	7C08712	Tapping of hydrocele NEC
42040	GP clinical event records	7C08.00	Excision of hydrocele
42040	GP clinical event records	7C08.11	Operations on hydrocoele
42040	GP clinical event records	7C08.12	Operations on hydrocoele sac
42040	GP clinical event records	7C08.13	Operations on hydrocele
42040	GP clinical event records	7C08y00	Other specified operation on hydrocele
42040	GP clinical event records	7C08z00	Operation on hydrocele NOS
42040	GP clinical event records	K230.00	Encysted hydrocele
42040	GP clinical event records	K231.00	Infected hydrocele
42040	GP clinical event records	K23..00	Hydrocele
42040	GP clinical event records	K23y.00	Other types of hydrocele
42040	GP clinical event records	K23z.00	Hydrocele NOS
42040	GP clinical event records	Kyu6200	[X]Other hydrocele
42040	GP clinical event records	Q476.00	Congenital hydrocele
42040	GP clinical event records	XE2R7	Congenital hydrocele
42040	GP clinical event records	XE0Gq	Excision of hydrocele