Metadata

Name Hypertension (hypertension)
Category Cardiovascular
Sex
Adult Yes
UUID 2559e028-2c5f-4270-bca0-2e2aac04a6e5
Definition Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.

Ontologies

Disease Ontology (DOID) DOID_10763
GWAS Catalogue EFO_0000537
MeSH D006973
SNOMED-CT 38341003
FinnGen I9_HYPTENS

Key Summary Statistics

Cases from any source

Total 167650
Female (%) 80028 (48%)
Male (%) 87622 (52%)

Year first recorded

hypertension year of first event

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Cross-sourced hypertension cases

Incidence & prevalence

Sex and age-stratified incidence and prevalence of hypertension

Baseline prevalence stratified by sex

Female 2008.63 (1981.67,2035.59)
Male 2609.47 (2577.27,2641.68)

Incidence stratified by sex

Female 142.14 (138.59,145.7)
Male 210.14 (205.16,215.12)

Incidence stratified by age

Ages 40-44 68.47 (63.1,73.84)
Ages 45-49 97.91 (92.26,103.57)
Ages 50-54 130.49 (124.22,136.76)
Ages 55-59 165.02 (158.33,171.71)
Ages 60-64 219.73 (212.68,226.78)
Ages 65-69 317.03 (306.49,327.57)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

CALIBER and UKB hypertension prevalence comparison for multiple age groups

Population Ages 40-49 Ages 50-59 Ages 60-69
UK Biobank 1248 (1214,1283) 2534 (2495,2573) 4201 (4158,4243)
CALIBER 1180 (1171, 2655 (2640, 4551 (4530,

Stratified by age and Townsend deprivation status

Deprivation status Ages 40-49 Ages 50-59 Ages 60-69
Least deprived 1056(982,1135) 2125(2046,2208) 3809(3722,3897)
Low 1069(993,1149) 2248(2165,2333) 3971(3883,4061)
Medium 1105(1031,1184) 2481(2395,2569) 4152(4060,4246)
High 1226(1154,1302) 2635(2547,2725) 4318(4220,4419)
Most deprived 1627(1550,1707) 3142(3048,3239) 4895(4786,5005)

Stratified by age and country

Country Ages 40-49 Ages 50-59 Ages 60-69
England 1251(1213,1290) 2528(2484,2572) 4197(4150,4245)
Scotland 1147(1053,1246) 2348(2247,2452) 3977(3857,4099)
Wales 1397(1265,1539) 2904(2759,3056) 4575(4417,4738)

Definition

UK Biobank field id Description Code Value
20002 Non-cancer illness code, self-reported 1072 essential hypertension
41202 Diagnoses - main ICD10 I10 Essential (primary) hypertension
41202 Diagnoses - main ICD10 I11 Hypertensive heart disease
41202 Diagnoses - main ICD10 I12 Hypertensive renal disease
41202 Diagnoses - main ICD10 I13 Hypertensive heart and renal disease
41202 Diagnoses - main ICD10 I15 Secondary hypertension
41204 Diagnoses - secondary ICD10 I10 Essential (primary) hypertension
41204 Diagnoses - secondary ICD10 I11 Hypertensive heart disease
41204 Diagnoses - secondary ICD10 I12 Hypertensive renal disease
41204 Diagnoses - secondary ICD10 I13 Hypertensive heart and renal disease
41204 Diagnoses - secondary ICD10 I15 Secondary hypertension
40001 Underlying (primary) cause of death: ICD10 I10 Essential (primary) hypertension
40001 Underlying (primary) cause of death: ICD10 I11 Hypertensive heart disease
40001 Underlying (primary) cause of death: ICD10 I12 Hypertensive renal disease
40001 Underlying (primary) cause of death: ICD10 I13 Hypertensive heart and renal disease
40001 Underlying (primary) cause of death: ICD10 I15 Secondary hypertension
40002 Contributory (secondary) causes of death: ICD10 I10 Essential (primary) hypertension
40002 Contributory (secondary) causes of death: ICD10 I11 Hypertensive heart disease
40002 Contributory (secondary) causes of death: ICD10 I12 Hypertensive renal disease
40002 Contributory (secondary) causes of death: ICD10 I13 Hypertensive heart and renal disease
40002 Contributory (secondary) causes of death: ICD10 I15 Secondary hypertension
42040 GP clinical event records 14A2.00 H/O: hypertension
42040 GP clinical event records 2126100 Hypertension resolved
42040 GP clinical event records 212K.00 Hypertension resolved
42040 GP clinical event records 9OI9.00 Hypertens.monitor deleted
42040 GP clinical event records 6624 Borderline hyperten:yearly obs
42040 GP clinical event records 6627 Good hypertension control
42040 GP clinical event records 6628 Poor hypertension control
42040 GP clinical event records 662F.00 Hypertension treatm. started
42040 GP clinical event records 662G.00 Hypertensive treatm.changed
42040 GP clinical event records 662O.00 On treatment for hypertension
42040 GP clinical event records 662b.00 Moderate hypertension control
42040 GP clinical event records 662c.00 Hypertension six month review
42040 GP clinical event records 662d.00 Hypertension annual review
42040 GP clinical event records 662r.00 Trial withdrawal of antihypertensive therapy
42040 GP clinical event records 7Q01.00 High cost hypertension drugs
42040 GP clinical event records 8B26.00 Antihypertensive therapy
42040 GP clinical event records 8BL0.00 Patient on maximal tolerated antihypertensive therapy
42040 GP clinical event records 8I3N.00 Hypertension treatment refused
42040 GP clinical event records F404200 Blind hypertensive eye
42040 GP clinical event records F421300 Hypertensive retinopathy
42040 GP clinical event records G2…00 Hypertensive disease
42040 GP clinical event records G2…11 BP - hypertensive disease
42040 GP clinical event records G20..00 Essential hypertension
42040 GP clinical event records G200.00 Malignant essential hypertension
42040 GP clinical event records G201.00 Benign essential hypertension
42040 GP clinical event records G202.00 Systolic hypertension
42040 GP clinical event records G203.00 Diastolic hypertension
42040 GP clinical event records G20z.00 Essential hypertension NOS
42040 GP clinical event records G20z.11 Hypertension NOS
42040 GP clinical event records G21..00 Hypertensive heart disease
42040 GP clinical event records G210.00 Malignant hypertensive heart disease
42040 GP clinical event records G210000 Malignant hypertensive heart disease without CCF
42040 GP clinical event records G210100 Malignant hypertensive heart disease with CCF
42040 GP clinical event records G211.00 Benign hypertensive heart disease
42040 GP clinical event records G211000 Benign hypertensive heart disease without CCF
42040 GP clinical event records G211100 Benign hypertensive heart disease with CCF
42040 GP clinical event records G21z.00 Hypertensive heart disease NOS
42040 GP clinical event records G21z000 Hypertensive heart disease NOS without CCF
42040 GP clinical event records G21z011 Cardiomegaly - hypertensive
42040 GP clinical event records G21z100 Hypertensive heart disease NOS with CCF
42040 GP clinical event records G21zz00 Hypertensive heart disease NOS
42040 GP clinical event records G22..00 Hypertensive renal disease
42040 GP clinical event records G220.00 Malignant hypertensive renal disease
42040 GP clinical event records G221.00 Benign hypertensive renal disease
42040 GP clinical event records G222.00 Hypertensive renal disease with renal failure
42040 GP clinical event records G22z.00 Hypertensive renal disease NOS
42040 GP clinical event records G22z.11 Renal hypertension
42040 GP clinical event records G23..00 Hypertensive heart and renal disease
42040 GP clinical event records G230.00 Malignant hypertensive heart and renal disease
42040 GP clinical event records G231.00 Benign hypertensive heart and renal disease
42040 GP clinical event records G232.00 Hypertensive heart&renal dis wth (congestive) heart failure
42040 GP clinical event records G233.00 Hypertensive heart and renal disease with renal failure
42040 GP clinical event records G234.00 Hyperten heart&renal dis+both(congestv)heart and renal fail
42040 GP clinical event records G23z.00 Hypertensive heart and renal disease NOS
42040 GP clinical event records G2y..00 Other specified hypertensive disease
42040 GP clinical event records G2z..00 Hypertensive disease NOS
42040 GP clinical event records G672.00 Hypertensive encephalopathy
42040 GP clinical event records G672.11 Hypertensive crisis
42040 GP clinical event records Gyu2.00 [X]Hypertensive diseases
42040 GP clinical event records L122.00 Other pre-existing hypertension in preg/childbirth/puerp
42040 GP clinical event records L122000 Other pre-existing hypertension in preg/childb/puerp unspec
42040 GP clinical event records L122100 Other pre-existing hypertension in preg/childb/puerp - deliv
42040 GP clinical event records L122300 Other pre-exist hypertension in preg/childb/puerp-not deliv
42040 GP clinical event records L122z00 Other pre-existing hypertension in preg/childb/puerp NOS
42040 GP clinical event records L127.00 Pre-eclampsia or eclampsia with pre-existing hypertension
42040 GP clinical event records L127z00 Pre-eclampsia or eclampsia + pre-existing hypertension NOS
42040 GP clinical event records L128.00 Pre-exist hypertension compl preg childbirth and puerperium
42040 GP clinical event records L128000 Pre-exist hyperten heart dis compl preg childbth+puerperium
42040 GP clinical event records L128200 Pre-exist 2ndry hypertens comp preg childbth and puerperium
42040 GP clinical event records TJC7.00 Adverse reaction to other antihypertensives
42040 GP clinical event records TJC7z00 Adverse reaction to antihypertensives NOS
42040 GP clinical event records U60C500 [X]Oth antihyperten drug caus advers eff in therap use, NEC
42040 GP clinical event records U60C511 [X] Adverse reaction to other antihypertensives
42040 GP clinical event records U60C51A [X] Adverse reaction to antihypertensives NOS
42040 GP clinical event records 6146200 Hypertension induced by oral contraceptive pill
42040 GP clinical event records G24..00 Secondary hypertension
42040 GP clinical event records G240.00 Secondary malignant hypertension
42040 GP clinical event records G240000 Secondary malignant renovascular hypertension
42040 GP clinical event records G240z00 Secondary malignant hypertension NOS
42040 GP clinical event records G241.00 Secondary benign hypertension
42040 GP clinical event records G241000 Secondary benign renovascular hypertension
42040 GP clinical event records G241z00 Secondary benign hypertension NOS
42040 GP clinical event records G244.00 Hypertension secondary to endocrine disorders
42040 GP clinical event records G24z.00 Secondary hypertension NOS
42040 GP clinical event records G24z000 Secondary renovascular hypertension NOS
42040 GP clinical event records G24z100 Hypertension secondary to drug
42040 GP clinical event records G24zz00 Secondary hypertension NOS
42040 GP clinical event records Gyu2100 [X]Hypertension secondary to other renal disorders
42040 GP clinical event records XE0VM Hypertensive encephalopathy
42040 GP clinical event records XaIyD Hypertension six month review
42040 GP clinical event records F4211 Hypertensive retinopathy
42040 GP clinical event records XE0Uc Essential hypertension
42040 GP clinical event records G21z. Hypertensive heart disease NOS
42040 GP clinical event records Xa8HD On treatment for hypertension
42040 GP clinical event records XaBLq Antihypertensive therapy
42040 GP clinical event records XaM5f High cost hypertension drugs
42040 GP clinical event records 21261 Hypertension resolved
42040 GP clinical event records XaNFs Trial withdrawal of antihypertensive therapy
42040 GP clinical event records XSDSb Diastolic hypertension
42040 GP clinical event records G24z. Secondary hypertension NOS
42040 GP clinical event records XaIy8 Moderate hypertension control
42040 GP clinical event records XaJ5h Patient on maximal tolerated antihypertensive therapy
42040 GP clinical event records XE0Ud Essential hypertension NOS
42040 GP clinical event records XE0Uf Hypertensive renal disease
42040 GP clinical event records XE0Uf Hypertensive renal disease
42040 GP clinical event records XE15r Blind hypertensive eye
42040 GP clinical event records XE0Ug Hypertensive renal disease NOS
42040 GP clinical event records XaIyC Hypertension treatment refused
42040 GP clinical event records XaIyE Hypertension annual review