Hyperthyroidism

Metadata

Name	Hyperthyroidism (hyperthyroid)
Category	Endocrine
Sex
Adult	Yes
UUID	06430866-ea2b-4fdf-a90e-8c847e468d2d

Ontologies

Disease Ontology (DOID)	DOID_7998
GWAS Catalogue	EFO_0009189
MeSH	D006980
SNOMED-CT	34486009
FinnGen	THYROTOXICOSIS

Key Summary Statistics

Cases from any source

Total	8905
Female (%)	7080 (80%)
Male (%)	1825 (20%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	235.17 (224.97,245.36)
Male	60.34 (54.66,66.02)

Incidence stratified by sex

Female	7.57 (6.85,8.3)
Male	2.46 (2.01,2.9)

Incidence stratified by age

Ages 40-44	4.68 (3.33,6.03)
Ages 45-49	5.26 (4.03,6.49)
Ages 50-54	5.03 (3.91,6.14)
Ages 55-59	5.34 (4.3,6.38)
Ages 60-64	4.81 (3.96,5.66)
Ages 65-69	6.04 (4.95,7.13)

Period prevalence

Methods

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	112 (102,122)	153 (144,163)	172 (164,181)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	100(79,126)	133(115,154)	158(141,176)
Low	103(82,129)	134(115,154)	167(150,186)
Medium	110(88,136)	149(130,170)	169(151,188)
High	114(93,138)	173(153,196)	183(164,204)
Most deprived	124(104,147)	175(154,198)	188(168,210)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	112(101,124)	144(134,154)	164(155,174)
Scotland	105(79,136)	187(161,217)	208(182,236)
Wales	117(82,162)	186(152,225)	196(165,232)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153646, Events=402

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.07 (0.82, 1.39)	0.637
BMI	obese	2.13 (1.65, 2.77)	1.06e-08
BMI	underweight	0 (0, Inf)	0.986
smoking	previous	1.48 (1.19, 1.85)	0.000498
smoking	current	2.47 (1.87, 3.26)	1.43e-10
hypertension	yes	2.21 (1.8, 2.72)	5.76e-14

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1225	hyperthyroidism/thyrotoxicosis
20002	Non-cancer illness code, self-reported	1522	grave’s disease
41202	Diagnoses - main ICD10	E05.0	Thyrotoxicosis with diffuse goitre
41202	Diagnoses - main ICD10	E05.1	Thyrotoxicosis with toxic single thyroid nodule
41202	Diagnoses - main ICD10	E05.2	Thyrotoxicosis with toxic multinodular goitre
41202	Diagnoses - main ICD10	E05.5	Thyroid crisis or storm
41202	Diagnoses - main ICD10	E05.8	Other thyrotoxicosis
41202	Diagnoses - main ICD10	E05.9	Thyrotoxicosis, unspecified
41202	Diagnoses - main ICD10	E06.2	Chronic thyroiditis with transient thyrotoxicosis
41202	Diagnoses - main ICD10	H06.2	Dysthyroid exophthalmos
41204	Diagnoses - secondary ICD10	E05.0	Thyrotoxicosis with diffuse goitre
41204	Diagnoses - secondary ICD10	E05.1	Thyrotoxicosis with toxic single thyroid nodule
41204	Diagnoses - secondary ICD10	E05.2	Thyrotoxicosis with toxic multinodular goitre
41204	Diagnoses - secondary ICD10	E05.5	Thyroid crisis or storm
41204	Diagnoses - secondary ICD10	E05.8	Other thyrotoxicosis
41204	Diagnoses - secondary ICD10	E05.9	Thyrotoxicosis, unspecified
41204	Diagnoses - secondary ICD10	E06.2	Chronic thyroiditis with transient thyrotoxicosis
41204	Diagnoses - secondary ICD10	H06.2	Dysthyroid exophthalmos
40001	Underlying (primary) cause of death: ICD10	E05.0	Thyrotoxicosis with diffuse goitre
40001	Underlying (primary) cause of death: ICD10	E05.1	Thyrotoxicosis with toxic single thyroid nodule
40001	Underlying (primary) cause of death: ICD10	E05.2	Thyrotoxicosis with toxic multinodular goitre
40001	Underlying (primary) cause of death: ICD10	E05.5	Thyroid crisis or storm
40001	Underlying (primary) cause of death: ICD10	E05.8	Other thyrotoxicosis
40001	Underlying (primary) cause of death: ICD10	E05.9	Thyrotoxicosis, unspecified
40001	Underlying (primary) cause of death: ICD10	E06.2	Chronic thyroiditis with transient thyrotoxicosis
40001	Underlying (primary) cause of death: ICD10	H06.2	Dysthyroid exophthalmos
40002	Contributory (secondary) causes of death: ICD10	E05.0	Thyrotoxicosis with diffuse goitre
40002	Contributory (secondary) causes of death: ICD10	E05.1	Thyrotoxicosis with toxic single thyroid nodule
40002	Contributory (secondary) causes of death: ICD10	E05.2	Thyrotoxicosis with toxic multinodular goitre
40002	Contributory (secondary) causes of death: ICD10	E05.5	Thyroid crisis or storm
40002	Contributory (secondary) causes of death: ICD10	E05.8	Other thyrotoxicosis
40002	Contributory (secondary) causes of death: ICD10	E05.9	Thyrotoxicosis, unspecified
40002	Contributory (secondary) causes of death: ICD10	E06.2	Chronic thyroiditis with transient thyrotoxicosis
40002	Contributory (secondary) causes of death: ICD10	H06.2	Dysthyroid exophthalmos
42040	GP clinical event records	1431.00	H/O: hyperthyroidism
42040	GP clinical event records	1431.11	H/O: thyrotoxicosis
42040	GP clinical event records	212P.00	Hyperthyroidism resolved
42040	GP clinical event records	C020000	Toxic diffuse goitre with no crisis
42040	GP clinical event records	C020100	Toxic diffuse goitre with crisis
42040	GP clinical event records	C020200	Thyroid-associated dermopathy
42040	GP clinical event records	C020.00	Toxic diffuse goitre
42040	GP clinical event records	C020.11	Basedow’s disease
42040	GP clinical event records	C020.12	Graves’ disease
42040	GP clinical event records	C020z00	Toxic diffuse goitre NOS
42040	GP clinical event records	C021000	Toxic uninodular goitre with no crisis
42040	GP clinical event records	C021.00	Toxic uninodular goitre
42040	GP clinical event records	C021z00	Toxic uninodular goitre NOS
42040	GP clinical event records	C022000	Toxic multinodular goitre with no crisis
42040	GP clinical event records	C022.00	Toxic multinodular goitre
42040	GP clinical event records	C022z00	Toxic multinodular goitre NOS
42040	GP clinical event records	C023000	Toxic nodular goitre unspecified with no crisis
42040	GP clinical event records	C023100	Toxic nodular goitre unspecified with crisis
42040	GP clinical event records	C023.00	Toxic nodular goitre unspecified
42040	GP clinical event records	C023z00	Toxic nodular goitre NOS
42040	GP clinical event records	C02..00	Thyrotoxicosis
42040	GP clinical event records	C02..11	Hyperthyroidism
42040	GP clinical event records	C02..12	Toxic goitre
42040	GP clinical event records	C02y000	Thyrotoxicosis of other specified origin with no crisis
42040	GP clinical event records	C02y100	Thyrotoxicosis of other specified origin with crisis
42040	GP clinical event records	C02y300	Thyroid crisis
42040	GP clinical event records	C02y.00	Thyrotoxicosis of other specified origin
42040	GP clinical event records	C02yz00	Thyrotoxicosis of other specified origin NOS
42040	GP clinical event records	C02z000	Thyrotoxicosis without mention of goitre or cause no crisis
42040	GP clinical event records	C02z100	Thyrotoxicosis without mention of goitre, cause with crisis
42040	GP clinical event records	C02z.00	Thyrotoxicosis without mention of goitre or other cause
42040	GP clinical event records	C02zz00	Thyrotoxicosis NOS
42040	GP clinical event records	Cyu1300	Myasthenic syndrome due to thyrotoxicosis
42040	GP clinical event records	F395400	Myopathy due to thyrotoxicosis
42040	GP clinical event records	F4G2000	Thyrotoxic exophthalmos
42040	GP clinical event records	FyuBD00	[X]Dysthyroid exophthalmos
42040	GP clinical event records	G557500	Thyrotoxic heart disease
42040	GP clinical event records	XE106	Thyrotoxicosis of other specified origin
42040	GP clinical event records	XE104	Thyrotoxicosis
42040	GP clinical event records	XaKcQ	Hyperthyroidism resolved
42040	GP clinical event records	X40Hd	Chronic thyroiditis with transient thyrotoxicosis
42040	GP clinical event records	XE105	Toxic diffuse goitre
42040	GP clinical event records	X40H3	Thyroid crisis