Hyposplenism

Metadata

Name	Hyposplenism (hyposplenism)
Category	Haematological or immunological
Sex
Adult	Yes
UUID	92becfad-ca7c-42ce-b29e-7b1fb195df4f
Definition	Reduced splenic function that is a dominant cause of primary immunodeficiency.

Ontologies

MeSH	C563028
SNOMED-CT	23761004
FinnGen	D3_HYPOSPLENISM

Key Summary Statistics

Cases from any source

Total	1227
Female (%)	580 (47%)
Male (%)	647 (53%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	16.03 (13.34,18.72)
Male	21.42 (18.03,24.81)

Incidence stratified by sex

Female	0.62 (0.41,0.82)
Male	0.7 (0.46,0.93)

Incidence stratified by age

Ages 40-44	0.3 (-0.04,0.64)
Ages 45-49	0.52 (0.13,0.9)
Ages 50-54	0.38 (0.08,0.68)
Ages 55-59	0.78 (0.39,1.18)
Ages 60-64	0.62 (0.31,0.92)
Ages 65-69	1.06 (0.6,1.51)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	18 (14,22)	22 (18,26)	24 (21,28)
CALIBER	16 (15,17)	22 (21,23)	27 (25,28)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	14(7,27)	19(12,28)	22(16,30)
Low	21(11,34)	22(15,32)	25(18,33)
Medium	21(12,34)	17(11,26)	23(17,31)
High	12(6,22)	28(19,38)	20(14,28)
Most deprived	20(13,31)	23(16,33)	33(24,43)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	19(15,25)	21(17,26)	23(19,27)
Scotland	10(3,24)	25(15,38)	36(25,50)
Wales	10(2,31)	23(12,39)	24(14,39)

Definition

UK Biobank field id	Description	Code	Value
41202	Diagnoses - main ICD10	D73.0	Hyposplenism
41202	Diagnoses - main ICD10	D73.5	Infarction of spleen
41204	Diagnoses - secondary ICD10	D73.0	Hyposplenism
41204	Diagnoses - secondary ICD10	D73.5	Infarction of spleen
40001	Underlying (primary) cause of death: ICD10	D73.0	Hyposplenism
40001	Underlying (primary) cause of death: ICD10	D73.5	Infarction of spleen
40002	Contributory (secondary) causes of death: ICD10	D73.0	Hyposplenism
40002	Contributory (secondary) causes of death: ICD10	D73.5	Infarction of spleen
42040	GP clinical event records	14N7.00	H/O: splenectomy
42040	GP clinical event records	7840100.0	Total splenectomy
42040	GP clinical event records	7840300.0	Splenectomy NEC
42040	GP clinical event records	7840400.0	Laparoscopic total splenectomy
42040	GP clinical event records	7840.00	Total excision of spleen
42040	GP clinical event records	7840.11	Total splenectomy
42040	GP clinical event records	7840y00	Other specified total excision of spleen
42040	GP clinical event records	7840z00	Total excision of spleen NOS
42040	GP clinical event records	7841.00	Other excision of spleen
42040	GP clinical event records	7841y00	Other specified other excision of spleen
42040	GP clinical event records	7841z00	Other excision of spleen NOS
42040	GP clinical event records	D415400	Splenic atrophy
42040	GP clinical event records	D415600	Splenic fibrosis
42040	GP clinical event records	D415700	Splenic infarction
42040	GP clinical event records	D415800	Non-traumatic rupture of spleen
42040	GP clinical event records	D415A00	Hyposplenism
42040	GP clinical event records	PK01.00	Absent spleen
42040	GP clinical event records	PK01.11	Asplenia
42040	GP clinical event records	PK06.00	Hypoplasia of spleen
42040	GP clinical event records	Xa0hO	Hyposplenism
42040	GP clinical event records	7840.	Total splenectomy
42040	GP clinical event records	XaEXw	Laparoscopic total splenectomy