Hypothyroidism

Metadata

Name	Hypothyroidism (hypothyroid)
Category	Endocrine
Sex
Adult	Yes
UUID	e8b1c337-f3aa-46ce-8926-35f62b69b9a6

Ontologies

Disease Ontology (DOID)	DOID_1459
GWAS Catalogue	EFO_0004705
MeSH	D007037
SNOMED-CT	40930008
FinnGen	HYPOTHYROIDISM

Key Summary Statistics

Cases from any source

Total	39029
Female (%)	31552 (81%)
Male (%)	7477 (19%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	935.59 (916.0,955.19)
Male	221.05 (210.27,231.83)

Incidence stratified by sex

Female	28.31 (26.86,29.77)
Male	11.11 (10.15,12.07)

Incidence stratified by age

Ages 40-44	14.42 (12.01,16.82)
Ages 45-49	17.05 (14.8,19.3)
Ages 50-54	21.07 (18.74,23.41)
Ages 55-59	20.41 (18.32,22.5)
Ages 60-64	22.75 (20.84,24.66)
Ages 65-69	20.84 (18.75,22.94)

Period prevalence

Methods

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	367 (349,385)	568 (551,586)	744 (727,762)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	297(260,338)	507(471,545)	675(640,712)
Low	386(343,433)	513(476,552)	711(675,749)
Medium	312(275,353)	563(524,603)	713(676,751)
High	373(335,413)	590(552,631)	781(741,822)
Most deprived	438(399,479)	663(622,707)	863(819,909)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	344(325,364)	546(526,565)	720(701,739)
Scotland	434(380,493)	602(554,653)	822(771,876)
Wales	503(428,587)	735(667,809)	879(812,951)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153646, Events=402

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.07 (0.82, 1.39)	0.637
BMI	obese	2.13 (1.65, 2.77)	1.06e-08
BMI	underweight	0 (0, Inf)	0.986
smoking	previous	1.48 (1.19, 1.85)	0.000498
smoking	current	2.47 (1.87, 3.26)	1.43e-10
hypertension	yes	2.21 (1.8, 2.72)	5.76e-14

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1226	hypothyroidism/myxoedema
41202	Diagnoses - main ICD10	E03.5	Myxoedema coma
41202	Diagnoses - main ICD10	E03.8	Other specified hypothyroidism
41202	Diagnoses - main ICD10	E03.9	Hypothyroidism, unspecified
41204	Diagnoses - secondary ICD10	E03.5	Myxoedema coma
41204	Diagnoses - secondary ICD10	E03.8	Other specified hypothyroidism
41204	Diagnoses - secondary ICD10	E03.9	Hypothyroidism, unspecified
40001	Underlying (primary) cause of death: ICD10	E03.5	Myxoedema coma
40001	Underlying (primary) cause of death: ICD10	E03.8	Other specified hypothyroidism
40001	Underlying (primary) cause of death: ICD10	E03.9	Hypothyroidism, unspecified
40002	Contributory (secondary) causes of death: ICD10	E03.5	Myxoedema coma
40002	Contributory (secondary) causes of death: ICD10	E03.8	Other specified hypothyroidism
40002	Contributory (secondary) causes of death: ICD10	E03.9	Hypothyroidism, unspecified
42040	GP clinical event records	1432.00	H/O: hypothyroidism
42040	GP clinical event records	66BB.00	Hypothyroidism annual review
42040	GP clinical event records	8CR5.00	Hypothyroidism clinical management plan
42040	GP clinical event records	9Oj0.00	Hypothyroidism monitoring first letter
42040	GP clinical event records	9Oj1.00	Hypothyroidism monitoring second letter
42040	GP clinical event records	9Oj2.00	Hypothyroidism monitoring third letter
42040	GP clinical event records	9Oj3.00	Hypothyroidism monitoring verbal invite
42040	GP clinical event records	9Oj4.00	Hypothyroidism monitoring telephone invitation
42040	GP clinical event records	9Oj..00	Hypothyroidism monitoring administration
42040	GP clinical event records	C040.00	Postsurgical hypothyroidism
42040	GP clinical event records	C040.11	Post ablative hypothyroidism
42040	GP clinical event records	C041000	Irradiation hypothyroidism
42040	GP clinical event records	C041.00	Other postablative hypothyroidism
42040	GP clinical event records	C041z00	Postablative hypothyroidism NOS
42040	GP clinical event records	C043.00	Other iatrogenic hypothyroidism
42040	GP clinical event records	C043z00	Iatrogenic hypothyroidism NOS
42040	GP clinical event records	C04..00	Acquired hypothyroidism
42040	GP clinical event records	C04..11	Myxoedema
42040	GP clinical event records	C04..12	Thyroid deficiency
42040	GP clinical event records	C04..13	Hypothyroidism
42040	GP clinical event records	C04y.00	Other acquired hypothyroidism
42040	GP clinical event records	C04z000	Premature puberty due to hypothyroidism
42040	GP clinical event records	C04z100	Myxoedema coma
42040	GP clinical event records	C04z.00	Hypothyroidism NOS
42040	GP clinical event records	C04z.11	Pretibial myxoedema - hypothyroid
42040	GP clinical event records	C04z.12	Thyroid insufficiency
42040	GP clinical event records	C04z.13	Hypothyroid goitre, acquired
42040	GP clinical event records	C06y100	Thyroid atrophy
42040	GP clinical event records	C134300	TSH - thyroid-stimulating hormone deficiency
42040	GP clinical event records	Cyu1100	[X]Other sp cified hypothyroidism
42040	GP clinical event records	F11x500	Cerebral degeneration due to myxoedema
42040	GP clinical event records	F381400	Myasthenic syndrome due to hypothyroidism
42040	GP clinical event records	F395300	Myopathy due to myxoedema
42040	GP clinical event records	XaJuE	Hypothyroidism monitoring administration
42040	GP clinical event records	XaOjl	Hypothyroidism annual review
42040	GP clinical event records	XE108	Acquired hypothyroidism
42040	GP clinical event records	XE108	Acquired hypothyroidism
42040	GP clinical event records	XaMFm	Hypothyroidism monitoring telephone invitation
42040	GP clinical event records	XaJYj	Hypothyroidism clinical management plan
42040	GP clinical event records	XaKbz	Hypothyroidism monitoring verbal invite
42040	GP clinical event records	X005I	Myxoedema coma
42040	GP clinical event records	XaJuN	Hypothyroidism monitoring second letter
42040	GP clinical event records	XaJuM	Hypothyroidism monitoring first letter
42040	GP clinical event records	XE10A	Hypothyroidism NOS
42040	GP clinical event records	XaJuO	Hypothyroidism monitoring third letter