Inflammatory bowel disease (IBD)

Metadata

Name	Inflammatory bowel disease (IBD) (IBD)
Category	Digestive
Sex
Adult	Yes
UUID	80a108a4-3c5b-449d-9634-27259d1ceb96
Definition	A group of chronic inflammatory diseases of the gastrointestinal tract.

Ontologies

Disease Ontology (DOID)	DOID_0050589
GWAS Catalogue	EFO_0003767
MeSH	D015212
SNOMED-CT	24526004
FinnGen	K11_IBD

Key Summary Statistics

Cases from any source

Total	8767
Female (%)	4549 (52%)
Male (%)	4218 (48%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	134.85 (127.09,142.61)
Male	144.47 (135.72,153.22)

Incidence stratified by sex

Female	3.78 (3.27,4.29)
Male	4.89 (4.26,5.53)

Incidence stratified by age

Ages 40-44	3.35 (2.21,4.5)
Ages 45-49	3.83 (2.78,4.89)
Ages 50-54	4.24 (3.22,5.26)
Ages 55-59	4.48 (3.53,5.43)
Ages 60-64	4.76 (3.91,5.6)
Ages 65-69	4.29 (3.37,5.21)

Period prevalence

Methods

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	134 (123,146)	150 (141,160)	168 (159,176)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	131(106,160)	144(124,167)	160(143,179)
Low	117(94,146)	157(136,180)	151(135,170)
Medium	126(102,154)	144(124,166)	151(134,170)
High	132(109,158)	160(140,183)	198(177,220)
Most deprived	157(134,183)	148(129,171)	183(162,205)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	129(117,142)	146(136,157)	164(155,173)
Scotland	166(132,206)	163(138,193)	186(161,214)
Wales	143(102,194)	170(136,209)	180(150,215)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153979, Events=141

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.41 (0.92, 2.17)	0.113
BMI	obese	1.52 (0.95, 2.43)	0.0832
BMI	underweight	0 (0, Inf)	0.992
smoking	previous	0.89 (0.63, 1.27)	0.531
smoking	current	0.83 (0.44, 1.56)	0.561
hypertension	yes	1.5 (1.06, 2.12)	0.0207

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1462	crohns disease
20002	Non-cancer illness code, self-reported	1463	ulcerative colitis
41202	Diagnoses - main ICD10	K50	Crohn’s disease [regional enteritis]
41202	Diagnoses - main ICD10	K51	Ulcerative colitis
41204	Diagnoses - secondary ICD10	K50	Crohn’s disease [regional enteritis]
41204	Diagnoses - secondary ICD10	K51	Ulcerative colitis
40001	Underlying (primary) cause of death: ICD10	K50	Crohn’s disease [regional enteritis]
40001	Underlying (primary) cause of death: ICD10	K51	Ulcerative colitis
40002	Contributory (secondary) causes of death: ICD10	K50	Crohn’s disease [regional enteritis]
40002	Contributory (secondary) causes of death: ICD10	K51	Ulcerative colitis
42040	GP clinical event records	J08z900	Orofacial Crohn’s disease
42040	GP clinical event records	J400000	Regional enteritis of the duodenum
42040	GP clinical event records	J400100	Regional enteritis of the jejunum
42040	GP clinical event records	J400200	Crohn’s disease of the terminal ileum
42040	GP clinical event records	J400300	Crohn’s disease of the ileum unspecified
42040	GP clinical event records	J400400	Crohn’s disease of the ileum NOS
42040	GP clinical event records	J400500	Exacerbation of Crohn’s disease of small intestine
42040	GP clinical event records	J400.00	Regional enteritis of the small bowel
42040	GP clinical event records	J400z00	Crohn’s disease of the small bowel NOS
42040	GP clinical event records	J401000	Regional enteritis of the colon
42040	GP clinical event records	J401100	Regional enteritis of the rectum
42040	GP clinical event records	J401200	Exacerbation of Crohn’s disease of large intestine
42040	GP clinical event records	J401.00	Regional enteritis of the large bowel
42040	GP clinical event records	J401z00	Crohn’s disease of the large bowel NOS
42040	GP clinical event records	J401z11	Crohn’s colitis
42040	GP clinical event records	J402.00	Regional ileocolitis
42040	GP clinical event records	J40..00	Regional enteritis - Crohn’s disease
42040	GP clinical event records	J40..11	Crohn’s disease
42040	GP clinical event records	J40..12	Granulomatous enteritis
42040	GP clinical event records	J40z.00	Regional enteritis NOS
42040	GP clinical event records	J40z.11	Crohn’s disease NOS
42040	GP clinical event records	Jyu4000	[X]Other Crohn’s disease
42040	GP clinical event records	N031100	Arthropathy in Crohn’s disease
42040	GP clinical event records	N045300	Juvenile arthritis in Crohn’s disease
42040	GP clinical event records	ZR3S.00	Crohn’s disease activity index
42040	GP clinical event records	ZR3S.11	CDAI - Crohn’s disease activity index
42040	GP clinical event records	XaK6D	Exacerbation of Crohn’s disease of large intestine
42040	GP clinical event records	XE0af	Crohn’s disease of the large bowel NOS
42040	GP clinical event records	XaK6C	Exacerbation of Crohn’s disease of small intestine
42040	GP clinical event records	14C4.11	H/O: ulcerative colitis
42040	GP clinical event records	J410000	Ulcerative ileocolitis
42040	GP clinical event records	J410100	Ulcerative colitis
42040	GP clinical event records	J410200	Ulcerative rectosigmoiditis
42040	GP clinical event records	J410300	Ulcerative proctitis
42040	GP clinical event records	J410400	Exacerbation of ulcerative colitis
42040	GP clinical event records	J410.00	Ulcerative proctocolitis
42040	GP clinical event records	J410z00	Ulcerative proctocolitis NOS
42040	GP clinical event records	J411.00	Ulcerative (chronic) enterocolitis
42040	GP clinical event records	J412.00	Ulcerative (chronic) ileocolitis
42040	GP clinical event records	J413.00	Ulcerative pancolitis
42040	GP clinical event records	J41..00	Idiopathic proctocolitis
42040	GP clinical event records	J41..11	Mucous colitis and/or proctitis
42040	GP clinical event records	J41..12	Ulcerative colitis and/or proctitis
42040	GP clinical event records	J41y.00	Other idiopathic proctocolitis
42040	GP clinical event records	J41yz00	Other idiopathic proctocolitis NOS
42040	GP clinical event records	J41z.00	Idiopathic proctocolitis NOS
42040	GP clinical event records	Jyu4100	[X]Other ulcerative colitis
42040	GP clinical event records	N031000	Arthropathy in ulcerative colitis
42040	GP clinical event records	N045400	Juvenile arthritis in ulcerative colitis
42040	GP clinical event records	XaYzX	Ulcerative pancolitis
42040	GP clinical event records	XE0ag	Ulcerative colitis
42040	GP clinical event records	XaK6E	Exacerbation of ulcerative colitis
42040	GP clinical event records	XE0qC	H/O: colitis