| Name |
Irritable bowel syndrome (IBS) |
| Category |
Digestive |
| Sex |
|
| Adult |
Yes |
| UUID |
15e4e23f-5048-4f70-8f32-8ae57de0f5c2 |
| Definition |
Irritable bowel syndrome (IBS), referred to previously as spastic or nervous colon, and spastic bowel, is a functional gastrointestinal disorder characterized by a group of symptoms accompanied together that include abdominal pain and changes in the consistency of bowel movements. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
26707 |
| Female (%) |
19612 (73%) |
| Male (%) |
7095 (27%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
590.92 (575.05,606.79) |
| Male |
249.47 (238.03,260.91) |
Incidence stratified by sex
| Female |
17.14 (16.03,18.25) |
| Male |
8.96 (8.1,9.83) |
Incidence stratified by age
| Ages 40-44 |
15.37 (12.87,17.87) |
| Ages 45-49 |
13.41 (11.41,15.42) |
| Ages 50-54 |
13.57 (11.7,15.43) |
| Ages 55-59 |
13.92 (12.21,15.64) |
| Ages 60-64 |
13.33 (11.9,14.77) |
| Ages 65-69 |
11.55 (10.03,13.08) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
361 (343,379) |
402 (387,417) |
369 (357,382) |
| CALIBER |
839 (832,847) |
865 (856,874) |
840 (831,849) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
345(304,390) |
413(380,449) |
376(350,404) |
| Low |
333(293,377) |
359(328,392) |
368(341,395) |
| Medium |
351(311,395) |
412(379,448) |
344(318,371) |
| High |
349(312,389) |
399(366,433) |
370(343,400) |
| Most deprived |
411(373,451) |
427(393,463) |
391(361,423) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
259(243,277) |
289(274,303) |
279(268,292) |
| Scotland |
700(631,776) |
739(685,797) |
673(625,723) |
| Wales |
907(803,1019) |
952(872,1038) |
841(775,912) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153979, Events=141
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
1.41 (0.92, 2.17) |
0.113 |
| BMI |
obese |
1.52 (0.95, 2.43) |
0.0832 |
| BMI |
underweight |
0 (0, Inf) |
0.992 |
| smoking |
previous |
0.89 (0.63, 1.27) |
0.531 |
| smoking |
current |
0.83 (0.44, 1.56) |
0.561 |
| hypertension |
yes |
1.5 (1.06, 2.12) |
0.0207 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1154 |
irritable bowel syndrome |
| 41202 |
Diagnoses - main ICD10 |
K58 |
Irritable bowel syndrome |
| 41204 |
Diagnoses - secondary ICD10 |
K58 |
Irritable bowel syndrome |
| 40001 |
Underlying (primary) cause of death: ICD10 |
K58 |
Irritable bowel syndrome |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
K58 |
Irritable bowel syndrome |
| 42040 |
GP clinical event records |
14CF.00 |
History of irritable bowel syndrome |
| 42040 |
GP clinical event records |
8Cm..00 |
Management of irritable bowel syndrome |
| 42040 |
GP clinical event records |
J521000 |
Irritable bowel syndrome with diarrhoea |
| 42040 |
GP clinical event records |
J521.00 |
Irritable colon - Irritable bowel syndrome |
| 42040 |
GP clinical event records |
J521.11 |
Irritable bowel syndrome |
| 42040 |
GP clinical event records |
J521.13 |
Spastic colon |
| 42040 |
GP clinical event records |
XaLBm |
History of irritable bowel syndrome |
| 42040 |
GP clinical event records |
XaYnp |
Management of irritable bowel syndrome |