Metadata
Name | Iron deficiency anaemia (IDA) |
Category | Haematological or immunological |
Sex | |
Adult | Yes |
UUID | a76d9012-7ebf-4e3d-9527-6e95b15433d7 |
Definition | Iron deficiency anemia is a common type of anemia — a condition in which blood lacks adequate healthy red blood cells. |
Ontologies
Disease Ontology (DOID) | DOID_11758 |
MeSH | D018798 |
SNOMED-CT | 87522002 |
FinnGen | D3_ANAEMIA_IRONDEF |
Key Summary Statistics
Cases from any source
Total | 27327 |
Female (%) | 17455 (64%) |
Male (%) | 9872 (36%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
Female | 387.46 (374.48,400.45) |
Male | 109.89 (102.25,117.54) |
Incidence stratified by sex
Female | 27.73 (26.33,29.13) |
Male | 23.7 (22.3,25.1) |
Incidence stratified by age
Ages 40-44 | 20.66 (17.79,23.53) |
Ages 45-49 | 23.01 (20.4,25.62) |
Ages 50-54 | 19.48 (17.26,21.7) |
Ages 55-59 | 21.19 (19.1,23.28) |
Ages 60-64 | 26.88 (24.86,28.91) |
Ages 65-69 | 38.63 (35.85,41.4) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
Population | Ages 40-49 | Ages 50-59 | Ages 60-69 |
UK Biobank | 321 (305,338) | 357 (343,371) | 382 (370,395) |
CALIBER | 434 (429,440) | 462 (456,469) | 521 (514,528) |
Stratified by age and Townsend deprivation status
Deprivation status | Ages 40-49 | Ages 50-59 | Ages 60-69 |
Least deprived | 295(258,335) | 302(274,332) | 314(289,339) |
Low | 266(231,305) | 338(308,370) | 345(319,372) |
Medium | 332(294,374) | 359(328,392) | 369(343,398) |
High | 323(288,361) | 350(320,382) | 402(372,433) |
Most deprived | 371(335,409) | 435(401,471) | 508(473,544) |
Stratified by age and country
Country | Ages 40-49 | Ages 50-59 | Ages 60-69 |
England | 296(278,314) | 330(315,346) | 359(346,373) |
Scotland | 373(323,428) | 454(412,499) | 482(442,525) |
Wales | 517(442,602) | 457(403,517) | 470(420,523) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153321, Events=259
Factor | Level | Hazard Ratio | P value |
BMI | overweight | 1.47 (1.07, 2.01) | 0.0165 |
BMI | obese | 2.46 (1.81, 3.35) | 1.19e-08 |
BMI | underweight | 0 (0, Inf) | 0.998 |
smoking | previous | 1.06 (0.81, 1.39) | 0.676 |
smoking | current | 0.75 (0.46, 1.22) | 0.25 |
hypertension | yes | 0.83 (0.58, 1.19) | 0.31 |
Definition
UK Biobank field id | Description | Code | Value |
---|---|---|---|
20002 | Non-cancer illness code, self-reported | 1330 | iron deficiency anaemia |
41202 | Diagnoses - main ICD10 | D50 | Iron deficiency anaemia |
41204 | Diagnoses - secondary ICD10 | D50 | Iron deficiency anaemia |
40001 | Underlying (primary) cause of death: ICD10 | D50 | Iron deficiency anaemia |
40002 | Contributory (secondary) causes of death: ICD10 | D50 | Iron deficiency anaemia |
42040 | GP clinical event records | D000.00 | Iron deficiency anaemia due to chronic blood loss |
42040 | GP clinical event records | D000.11 | Normocytic anaemia due to chronic blood loss |
42040 | GP clinical event records | D000.12 | Iron deficiency anaemia due to blood loss |
42040 | GP clinical event records | D001.00 | Iron deficiency anaemia due to dietary causes |
42040 | GP clinical event records | D00..00 | Iron deficiency anaemias |
42040 | GP clinical event records | D00y000 | Sideropenic dysphagia |
42040 | GP clinical event records | D00y011 | Kelly-Paterson syndrome |
42040 | GP clinical event records | D00y012 | Plummer-Vinson syndrome |
42040 | GP clinical event records | D00y.00 | Other specified iron deficiency anaemia |
42040 | GP clinical event records | D00y.11 | Kelly - Paterson syndrome |
42040 | GP clinical event records | D00y.12 | Plummer - Vinson syndrome |
42040 | GP clinical event records | D00yz00 | Other specified iron deficiency anaemia NOS |
42040 | GP clinical event records | D00z000 | Achlorhydric anaemia |
42040 | GP clinical event records | D00z100 | Chlorotic anaemia |
42040 | GP clinical event records | D00z.00 | Unspecified iron deficiency anaemia |
42040 | GP clinical event records | D00zz00 | Iron deficiency anaemia NOS |
42040 | GP clinical event records | D0…11 | Asiderotic anaemia |
42040 | GP clinical event records | D0…12 | Sideropenic anaemia |
42040 | GP clinical event records | Dyu0000 | [X]Other iron deficiency anaemias |
42040 | GP clinical event records | XE13d | Iron deficiency anaemia due to chronic blood loss |
42040 | GP clinical event records | XE13d | Iron deficiency anaemia due to chronic blood loss |
42040 | GP clinical event records | XE13b | Deficiency anaemias |
42040 | GP clinical event records | XE13e | Other specified iron deficiency anaemia |