Metadata

Name Iron deficiency anaemia (IDA)
Category Haematological or immunological
Sex
Adult Yes
UUID a76d9012-7ebf-4e3d-9527-6e95b15433d7
Definition Iron deficiency anemia is a common type of anemia — a condition in which blood lacks adequate healthy red blood cells.

Ontologies

Disease Ontology (DOID) DOID_11758
MeSH D018798
SNOMED-CT 87522002
FinnGen D3_ANAEMIA_IRONDEF

Key Summary Statistics

Cases from any source

Total 27327
Female (%) 17455 (64%)
Male (%) 9872 (36%)

Year first recorded

IDA year of first event

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Cross-sourced IDA cases

Incidence & prevalence

Sex and age-stratified incidence and prevalence of IDA

Baseline prevalence stratified by sex

Female 387.46 (374.48,400.45)
Male 109.89 (102.25,117.54)

Incidence stratified by sex

Female 27.73 (26.33,29.13)
Male 23.7 (22.3,25.1)

Incidence stratified by age

Ages 40-44 20.66 (17.79,23.53)
Ages 45-49 23.01 (20.4,25.62)
Ages 50-54 19.48 (17.26,21.7)
Ages 55-59 21.19 (19.1,23.28)
Ages 60-64 26.88 (24.86,28.91)
Ages 65-69 38.63 (35.85,41.4)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

CALIBER and UKB IDA prevalence comparison for multiple age groups

Population Ages 40-49 Ages 50-59 Ages 60-69
UK Biobank 321 (305,338) 357 (343,371) 382 (370,395)
CALIBER 434 (429,440) 462 (456,469) 521 (514,528)

Stratified by age and Townsend deprivation status

Deprivation status Ages 40-49 Ages 50-59 Ages 60-69
Least deprived 295(258,335) 302(274,332) 314(289,339)
Low 266(231,305) 338(308,370) 345(319,372)
Medium 332(294,374) 359(328,392) 369(343,398)
High 323(288,361) 350(320,382) 402(372,433)
Most deprived 371(335,409) 435(401,471) 508(473,544)

Stratified by age and country

Country Ages 40-49 Ages 50-59 Ages 60-69
England 296(278,314) 330(315,346) 359(346,373)
Scotland 373(323,428) 454(412,499) 482(442,525)
Wales 517(442,602) 457(403,517) 470(420,523)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153321, Events=259

Factor Level Hazard Ratio P value
BMI overweight 1.47 (1.07, 2.01) 0.0165
BMI obese 2.46 (1.81, 3.35) 1.19e-08
BMI underweight 0 (0, Inf) 0.998
smoking previous 1.06 (0.81, 1.39) 0.676
smoking current 0.75 (0.46, 1.22) 0.25
hypertension yes 0.83 (0.58, 1.19) 0.31

Risk factors analysis forest plot

Definition

UK Biobank field id Description Code Value
20002 Non-cancer illness code, self-reported 1330 iron deficiency anaemia
41202 Diagnoses - main ICD10 D50 Iron deficiency anaemia
41204 Diagnoses - secondary ICD10 D50 Iron deficiency anaemia
40001 Underlying (primary) cause of death: ICD10 D50 Iron deficiency anaemia
40002 Contributory (secondary) causes of death: ICD10 D50 Iron deficiency anaemia
42040 GP clinical event records D000.00 Iron deficiency anaemia due to chronic blood loss
42040 GP clinical event records D000.11 Normocytic anaemia due to chronic blood loss
42040 GP clinical event records D000.12 Iron deficiency anaemia due to blood loss
42040 GP clinical event records D001.00 Iron deficiency anaemia due to dietary causes
42040 GP clinical event records D00..00 Iron deficiency anaemias
42040 GP clinical event records D00y000 Sideropenic dysphagia
42040 GP clinical event records D00y011 Kelly-Paterson syndrome
42040 GP clinical event records D00y012 Plummer-Vinson syndrome
42040 GP clinical event records D00y.00 Other specified iron deficiency anaemia
42040 GP clinical event records D00y.11 Kelly - Paterson syndrome
42040 GP clinical event records D00y.12 Plummer - Vinson syndrome
42040 GP clinical event records D00yz00 Other specified iron deficiency anaemia NOS
42040 GP clinical event records D00z000 Achlorhydric anaemia
42040 GP clinical event records D00z100 Chlorotic anaemia
42040 GP clinical event records D00z.00 Unspecified iron deficiency anaemia
42040 GP clinical event records D00zz00 Iron deficiency anaemia NOS
42040 GP clinical event records D0…11 Asiderotic anaemia
42040 GP clinical event records D0…12 Sideropenic anaemia
42040 GP clinical event records Dyu0000 [X]Other iron deficiency anaemias
42040 GP clinical event records XE13d Iron deficiency anaemia due to chronic blood loss
42040 GP clinical event records XE13d Iron deficiency anaemia due to chronic blood loss
42040 GP clinical event records XE13b Deficiency anaemias
42040 GP clinical event records XE13e Other specified iron deficiency anaemia