Intracerebral haemorrhage

Metadata

Name	Intracerebral haemorrhage (Intracereb_haem)
Category	Cardiovascular
Sex
Adult	Yes
UUID	9319dbe0-6188-401a-baba-837595d54cd9
Definition	Bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma.

Ontologies

GWAS Catalogue	EFO_0005669
MeSH	D002543
SNOMED-CT	274100004
FinnGen	I9_ICH

Key Summary Statistics

Cases from any source

Total	2446
Female (%)	1085 (44%)
Male (%)	1361 (56%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	10.84 (8.63,13.06)
Male	23.66 (20.1,27.22)

Incidence stratified by sex

Female	1.56 (1.24,1.89)
Male	2.89 (2.41,3.37)

Incidence stratified by age

Ages 40-44	0.6 (0.12,1.09)
Ages 45-49	0.74 (0.28,1.2)
Ages 50-54	1.27 (0.71,1.82)
Ages 55-59	1.93 (1.31,2.55)
Ages 60-64	2.19 (1.62,2.76)
Ages 65-69	4.83 (3.87,5.8)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	9 (6,12)	22 (18,26)	35 (32,39)
CALIBER	12 (11,13)	25 (23,26)	51 (49,53)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	2(0,9)	15(9,23)	32(24,41)
Low	5(1,14)	11(6,19)	26(19,35)
Medium	8(3,18)	26(18,36)	38(30,48)
High	12(6,22)	25(17,36)	40(31,51)
Most deprived	14(7,23)	30(22,42)	42(32,53)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	9(6,13)	18(15,22)	34(30,39)
Scotland	5(1,17)	35(24,50)	35(25,48)
Wales	13(4,34)	31(18,52)	48(33,68)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=154060, Events=218

Factor	Level	Hazard Ratio	P value
BMI	overweight	0.89 (0.65, 1.23)	0.488
BMI	obese	1.16 (0.82, 1.63)	0.404
BMI	underweight	0 (0, Inf)	0.989
smoking	previous	1.75 (1.31, 2.35)	0.000182
smoking	current	2.37 (1.58, 3.55)	3.07e-05
hypertension	yes	1 (0.74, 1.36)	0.997

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1491	brain haemorrhage
41202	Diagnoses - main ICD10	I61	Intracerebral haemorrhage
41202	Diagnoses - main ICD10	I69.1	Sequelae of intracerebral haemorrhage
41204	Diagnoses - secondary ICD10	I61	Intracerebral haemorrhage
41204	Diagnoses - secondary ICD10	I69.1	Sequelae of intracerebral haemorrhage
40001	Underlying (primary) cause of death: ICD10	I61	Intracerebral haemorrhage
40001	Underlying (primary) cause of death: ICD10	I69.1	Sequelae of intracerebral haemorrhage
40002	Contributory (secondary) causes of death: ICD10	I61	Intracerebral haemorrhage
40002	Contributory (secondary) causes of death: ICD10	I69.1	Sequelae of intracerebral haemorrhage
42040	GP clinical event records	662o.00	Haemorrhagic stroke monitoring
42040	GP clinical event records	7004300.0	Evacuation of intracerebral haematoma NEC
42040	GP clinical event records	G610.00	Cortical haemorrhage
42040	GP clinical event records	G611.00	Internal capsule haemorrhage
42040	GP clinical event records	G612.00	Basal nucleus haemorrhage
42040	GP clinical event records	G613.00	Cerebellar haemorrhage
42040	GP clinical event records	G614.00	Pontine haemorrhage
42040	GP clinical event records	G615.00	Bulbar haemorrhage
42040	GP clinical event records	G616.00	External capsule haemorrhage
42040	GP clinical event records	G617.00	Intracerebral haemorrhage, intraventricular
42040	GP clinical event records	G618.00	Intracerebral haemorrhage, multiple localized
42040	GP clinical event records	G619.00	Lobar cerebral haemorrhage
42040	GP clinical event records	G61..00	Intracerebral haemorrhage
42040	GP clinical event records	G61..11	CVA - cerebrovascular accid due to intracerebral haemorrhage
42040	GP clinical event records	G61..12	Stroke due to intracerebral haemorrhage
42040	GP clinical event records	G61X000	Left sided intracerebral haemorrhage, unspecified
42040	GP clinical event records	G61X100	Right sided intracerebral haemorrhage, unspecified
42040	GP clinical event records	G61X.00	Intracerebral haemorrhage in hemisphere, unspecified
42040	GP clinical event records	G61z.00	Intracerebral haemorrhage NOS
42040	GP clinical event records	G681.00	Sequelae of intracerebral haemorrhage
42040	GP clinical event records	G682.00	Sequelae of other nontraumatic intracranial haemorrhage
42040	GP clinical event records	Gyu6200	[X]Other intracerebral haemorrhage
42040	GP clinical event records	Gyu6F00	[X]Intracerebral haemorrhage in hemisphere, unspecified
42040	GP clinical event records	XaBM4	Left sided intracerebral haemorrhage, unspecified
42040	GP clinical event records	XaKSH	Haemorrhagic stroke monitoring
42040	GP clinical event records	X00DM	Lobar cerebral haemorrhage
42040	GP clinical event records	XaBM5	Right sided intracerebral haemorrhage, unspecified