Juvenile arthritis

Metadata

Name	Juvenile arthritis (juv_arth)
Category	Musculoskeletal
Sex
Adult	Yes
UUID	0c8410f3-5839-4c70-926c-5cf70efade3c
Definition	Juvenile arthritis (JA), also known as pediatric rheumatic disease, isn’t a specific disease. It’s an umbrella term to describe the inflammatory and rheumatic diseases that develop in children under the age of 16.

Ontologies

Disease Ontology (DOID)	DOID_676
GWAS Catalogue	EFO_0002609
MeSH	D001171
SNOMED-CT	239796000
FinnGen	JUVEN_ARTHR

Key Summary Statistics

Cases from any source

Total	109
Female (%)	77 (71%)
Male (%)	32 (29%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	2.24 (1.23,3.25)
Male	1.82 (0.83,2.81)

Incidence stratified by sex

Female	0.12 (0.03,0.21)
Male	0.06 (-0.01,0.13)

Incidence stratified by age

Ages 40-44	0.0 (0.0,0.0)
Ages 45-49	0.22 (-0.03,0.47)
Ages 50-54	0.13 (-0.05,0.3)
Ages 55-59	0.05 (-0.05,0.15)
Ages 60-64	0.0 (0.0,0.0)
Ages 65-69	0.2 (0.0,0.4)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	4 (2,6)	3 (2,5)	2 (1,3)
CALIBER	5 (5,6)	3 (3,4)	–

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	0(NaN,NaN)	2(0,7)	1(0,4)
Low	7(2,15)	2(0,6)	3(1,7)
Medium	5(1,12)	2(0,6)	2(1,5)
High	4(1,11)	5(2,11)	2(1,6)
Most deprived	4(1,10)	4(2,9)	1(0,4)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	4(2,6)	3(2,5)	2(1,3)
Scotland	6(1,19)	5(1,12)	2(0,7)
Wales	3(0,17)	2(0,9)	0(NaN,NaN)

Definition

UK Biobank field id	Description	Code	Value
41202	Diagnoses - main ICD10	M08	Juvenile arthritis
41202	Diagnoses - main ICD10	M09	Juvenile arthritis in diseases classified elsewhere
41204	Diagnoses - secondary ICD10	M08	Juvenile arthritis
41204	Diagnoses - secondary ICD10	M09	Juvenile arthritis in diseases classified elsewhere
40001	Underlying (primary) cause of death: ICD10	M08	Juvenile arthritis
40001	Underlying (primary) cause of death: ICD10	M09	Juvenile arthritis in diseases classified elsewhere
40002	Contributory (secondary) causes of death: ICD10	M08	Juvenile arthritis
40002	Contributory (secondary) causes of death: ICD10	M09	Juvenile arthritis in diseases classified elsewhere
42040	GP clinical event records	N043000	Juvenile rheumatoid arthropathy unspecified
42040	GP clinical event records	N043100	Acute polyarticular juvenile rheumatoid arthritis
42040	GP clinical event records	N043200	Pauciarticular juvenile rheumatoid arthritis
42040	GP clinical event records	N043300	Monarticular juvenile rheumatoid arthritis
42040	GP clinical event records	N043.00	Juvenile rheumatoid arthritis - Still’s disease
42040	GP clinical event records	N043z00	Juvenile rheumatoid arthritis NOS
42040	GP clinical event records	N045000	Juvenile ankylosing spondylitis
42040	GP clinical event records	N045100	Juvenile seronegative polyarthritis
42040	GP clinical event records	N045200	Juvenile arthritis in psoriasis
42040	GP clinical event records	N045300	Juvenile arthritis in Crohn’s disease
42040	GP clinical event records	N045400	Juvenile arthritis in ulcerative colitis
42040	GP clinical event records	N045500	Juvenile rheumatoid arthritis
42040	GP clinical event records	N045600	Pauciarticular onset juvenile chronic arthritis
42040	GP clinical event records	N045.00	Other juvenile arthritis
42040	GP clinical event records	Nyu1500	[X]Other juvenile arthritis
42040	GP clinical event records	X701t	Juvenile rheumatoid arthritis
42040	GP clinical event records	N0432	Pauciarticular onset juvenile chronic arthritis
42040	GP clinical event records	X701x	Juvenile ankylosing spondylitis