Keratitis

Metadata

Name	Keratitis (keratitis)
Category	Skin
Sex
Adult	Yes
UUID	1f652d03-2fe0-41c5-875d-74a4c09b5603
Definition	Keratitis is an inflammation of the cornea — the clear, dome-shaped tissue on the front of your eye that covers the pupil and iris.

Ontologies

Disease Ontology (DOID)	DOID_4677
GWAS Catalogue	EFO_0009449
MeSH	D007634
SNOMED-CT	5888003
FinnGen	H7_KERATITIS

Key Summary Statistics

Cases from any source

Total	2304
Female (%)	1325 (58%)
Male (%)	979 (42%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	51.39 (46.58,56.21)
Male	48.58 (43.48,53.68)

Incidence stratified by sex

Female	4.03 (3.51,4.55)
Male	3.15 (2.65,3.66)

Incidence stratified by age

Ages 40-44	3.64 (2.45,4.82)
Ages 45-49	3.13 (2.19,4.08)
Ages 50-54	3.25 (2.36,4.14)
Ages 55-59	2.87 (2.11,3.63)
Ages 60-64	4.21 (3.42,5.0)
Ages 65-69	4.24 (3.34,5.15)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	63 (55,71)	68 (62,75)	82 (76,88)
CALIBER	78 (76,80)	239 (235,244)	586 (578,594)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	60(43,81)	67(54,83)	75(63,88)
Low	60(43,80)	67(53,83)	85(73,99)
Medium	79(60,103)	78(64,94)	83(71,97)
High	60(45,78)	71(57,87)	81(68,95)
Most deprived	57(43,73)	59(47,74)	87(73,103)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	58(50,67)	65(58,72)	81(75,88)
Scotland	87(63,117)	64(48,82)	77(61,96)
Wales	77(49,116)	114(87,146)	101(78,127)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153595, Events=126

Factor	Level	Hazard Ratio	P value
BMI	overweight	0.75 (0.51, 1.1)	0.143
BMI	obese	0.53 (0.31, 0.88)	0.014
BMI	underweight	0 (0, Inf)	0.992
smoking	previous	1.05 (0.71, 1.56)	0.804
smoking	current	1.31 (0.76, 2.25)	0.339
hypertension	yes	1.64 (1.09, 2.47)	0.0186

Definition

UK Biobank field id	Description	Code	Value
41202	Diagnoses - main ICD10	H16	Keratitis
41202	Diagnoses - main ICD10	H19.1	Herpesviral keratitis and keratoconjunctivitis
41202	Diagnoses - main ICD10	H19.2	Keratitis and keratoconjunctivitis in other infectious and parasitic diseases classified elsewhere
41202	Diagnoses - main ICD10	H19.3	Keratitis and keratoconjunctivitis in other diseases classified elsewhere
41204	Diagnoses - secondary ICD10	H16	Keratitis
41204	Diagnoses - secondary ICD10	H19.1	Herpesviral keratitis and keratoconjunctivitis
41204	Diagnoses - secondary ICD10	H19.2	Keratitis and keratoconjunctivitis in other infectious and parasitic diseases classified elsewhere
41204	Diagnoses - secondary ICD10	H19.3	Keratitis and keratoconjunctivitis in other diseases classified elsewhere
40001	Underlying (primary) cause of death: ICD10	H16	Keratitis
40001	Underlying (primary) cause of death: ICD10	H19.1	Herpesviral keratitis and keratoconjunctivitis
40001	Underlying (primary) cause of death: ICD10	H19.2	Keratitis and keratoconjunctivitis in other infectious and parasitic diseases classified elsewhere
40001	Underlying (primary) cause of death: ICD10	H19.3	Keratitis and keratoconjunctivitis in other diseases classified elsewhere
40002	Contributory (secondary) causes of death: ICD10	H16	Keratitis
40002	Contributory (secondary) causes of death: ICD10	H19.1	Herpesviral keratitis and keratoconjunctivitis
40002	Contributory (secondary) causes of death: ICD10	H19.2	Keratitis and keratoconjunctivitis in other infectious and parasitic diseases classified elsewhere
40002	Contributory (secondary) causes of death: ICD10	H19.3	Keratitis and keratoconjunctivitis in other diseases classified elsewhere
42040	GP clinical event records	A173200	Tuberculous interstitial keratitis
42040	GP clinical event records	A173400	Tuberculous keratoconjunctivitis
42040	GP clinical event records	A532100	Herpes zoster with keratoconjunctivitis
42040	GP clinical event records	A544200	Herpes simplex dendritic keratitis
42040	GP clinical event records	A544300	Herpes simplex disciform keratitis
42040	GP clinical event records	A55x000	Measles keratoconjunctivitis
42040	GP clinical event records	A771.00	Epidemic keratoconjunctivitis
42040	GP clinical event records	A776.00	Keratoconjunctivitis due to adenovirus
42040	GP clinical event records	A903.00	Syphilitic interstitial keratitis
42040	GP clinical event records	A984300	Gonococcal keratitis
42040	GP clinical event records	AD67000	Acanthamoeba keratitis
42040	GP clinical event records	F4A1.00	Dendritic keratitis
42040	GP clinical event records	F4A2000	Unspecified superficial keratitis
42040	GP clinical event records	F4A2100	Punctate keratitis
42040	GP clinical event records	F4A2112	Thygeson’s superficial punctate keratitis
42040	GP clinical event records	F4A2200	Nummular keratitis
42040	GP clinical event records	F4A2300	Striate keratitis
42040	GP clinical event records	F4A2400	Macular keratitis NOS
42040	GP clinical event records	F4A2500	Filamentary keratitis
42040	GP clinical event records	F4A2.00	Other superficial keratitis without conjunctivitis
42040	GP clinical event records	F4A2z00	Other superficial keratitis without conjunctivitis NOS
42040	GP clinical event records	F4A3000	Phlyctenular keratoconjunctivitis
42040	GP clinical event records	F4A3300	Exposure keratoconjunctivitis
42040	GP clinical event records	F4A3400	Neurotrophic keratoconjunctivitis
42040	GP clinical event records	F4A3.00	Specific keratoconjunctivitis
42040	GP clinical event records	F4A3z00	Specific keratoconjunctivitis NOS
42040	GP clinical event records	F4A4000	Unspecified keratoconjunctivitis
42040	GP clinical event records	F4A4100	Keratitis or keratoconjunctivitis in other exanthemata
42040	GP clinical event records	F4A4.00	Other keratoconjunctivitis
42040	GP clinical event records	F4A4z00	Other keratoconjunctivitis NOS
42040	GP clinical event records	F4A5000	Unspecified interstitial keratitis
42040	GP clinical event records	F4A5100	Diffuse interstitial keratitis
42040	GP clinical event records	F4A5200	Sclerosing keratitis
42040	GP clinical event records	F4A5400	Keratitis due to syphilis
42040	GP clinical event records	F4A5500	Keratitis due to tuberculosis
42040	GP clinical event records	F4A5.00	Interstitial and deep keratitis
42040	GP clinical event records	F4A5z00	Interstitial and deep keratitis NOS
42040	GP clinical event records	F4A..00	Keratitis
42040	GP clinical event records	F4A..11	Keratoconjunctivitis
42040	GP clinical event records	F4Ay.00	Other forms of keratitis
42040	GP clinical event records	F4Az.00	Keratitis NOS
42040	GP clinical event records	FyuD100	[X]Other superficial keratitis without conjunctivitis
42040	GP clinical event records	FyuD200	[X]Other keratitis
42040	GP clinical event records	FyuDA00	[X]Keratitis+keratoconjunctivitis in other diseases CE
42040	GP clinical event records	XE16N	Keratitis
42040	GP clinical event records	X00ab	Acanthamoeba keratitis
42040	GP clinical event records	XE16R	Diffuse interstitial keratitis