| Name |
Leiomyoma of uterus (leiomyoma) |
| Category |
Benign neoplasm or Carcinoma in situ |
| Sex |
|
| Adult |
Yes |
| UUID |
5f67efaf-9c9f-482d-945c-800b547eaea6 |
| Definition |
A benign smooth muscle neoplasm arising from the body of the uterus. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
26629 |
| Female (%) |
26629 (100%) |
| Male (%) |
0 (0%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
876.18 (857.16,895.21) |
| Male |
0.0 (0.0,0.0) |
Incidence stratified by sex
| Female |
30.32 (28.81,31.82) |
| Male |
0.0 (0.0,0.0) |
Incidence stratified by age
| Ages 40-44 |
37.87 (33.97,41.76) |
| Ages 45-49 |
36.09 (32.8,39.39) |
| Ages 50-54 |
18.49 (16.3,20.68) |
| Ages 55-59 |
9.82 (8.38,11.26) |
| Ages 60-64 |
7.16 (6.1,8.21) |
| Ages 65-69 |
5.57 (4.51,6.63) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
493 (473,514) |
510 (494,527) |
386 (374,398) |
| CALIBER |
770 (760,781) |
953 (940,966) |
699 (687,711) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
443(398,492) |
503(468,541) |
400(373,428) |
| Low |
463(417,513) |
479(444,515) |
384(358,412) |
| Medium |
456(412,504) |
503(468,540) |
394(367,422) |
| High |
502(459,547) |
555(518,593) |
388(361,417) |
| Most deprived |
574(529,620) |
509(474,547) |
358(330,387) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
518(495,542) |
524(506,543) |
389(375,403) |
| Scotland |
337(292,388) |
447(406,490) |
386(352,423) |
| Wales |
486(414,568) |
485(431,544) |
352(310,397) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153561, Events=310
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.89 (0.68, 1.17) |
0.406 |
| BMI |
obese |
1.13 (0.84, 1.51) |
0.416 |
| BMI |
underweight |
0 (0, Inf) |
0.987 |
| smoking |
previous |
0.95 (0.75, 1.22) |
0.699 |
| smoking |
current |
1.05 (0.72, 1.55) |
0.789 |
| hypertension |
yes |
1.12 (0.87, 1.45) |
0.386 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1351 |
uterine fibroids |
| 41202 |
Diagnoses - main ICD10 |
D25 |
Leiomyoma of uterus |
| 41204 |
Diagnoses - secondary ICD10 |
D25 |
Leiomyoma of uterus |
| 40001 |
Underlying (primary) cause of death: ICD10 |
D25 |
Leiomyoma of uterus |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
D25 |
Leiomyoma of uterus |
| 42040 |
GP clinical event records |
7A54A00 |
Perc embolisation of uterine fibroid using fluoroscopic guid |
| 42040 |
GP clinical event records |
7E06111 |
Excision fibroid |
| 42040 |
GP clinical event records |
7E0DC00 |
Transcervical resection of fibroid |
| 42040 |
GP clinical event records |
B780.00 |
Submucous uterine leiomyoma |
| 42040 |
GP clinical event records |
B781.00 |
Intramural uterine leiomyoma |
| 42040 |
GP clinical event records |
B781.11 |
Mural fibroids |
| 42040 |
GP clinical event records |
B782.00 |
Subserous uterine leiomyoma |
| 42040 |
GP clinical event records |
B78..00 |
Uterine leiomyoma - fibroids |
| 42040 |
GP clinical event records |
B78..11 |
Fibroids |
| 42040 |
GP clinical event records |
B78z.00 |
Uterine leiomyoma NOS |
| 42040 |
GP clinical event records |
BBK0000 |
[M]Leiomyoma NOS |
| 42040 |
GP clinical event records |
BBK0011 |
[M]Fibroid uterus |
| 42040 |
GP clinical event records |
BBK0300 |
[M]Epithelioid leiomyoma |
| 42040 |
GP clinical event records |
BBK0500 |
[M]Cellular leiomyoma |
| 42040 |
GP clinical event records |
BBK0600 |
[M]Bizarre leiomyoma |
| 42040 |
GP clinical event records |
BBK0.00 |
[M]Leiomyomatous neoplasms |
| 42040 |
GP clinical event records |
BBK0z00 |
[M]Leiomyomatous neoplasm NOS |
| 42040 |
GP clinical event records |
XaQYZ |
Percutaneous embolisation of uterine fibroid using fluoroscopic guidance |
| 40006 |
Type of cancer: ICD10 |
D25 |
Leiomyoma of uterus |