Leukaemia

Metadata

Name	Leukaemia (leukaemia)
Category	Cancers
Sex
Adult	Yes
UUID	857995a1-a553-4310-8928-92f3fc97abc1
Definition	A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells.

Ontologies

Disease Ontology (DOID)	DOID_1240
GWAS Catalogue	EFO_0000565
MeSH	D007938
SNOMED-CT	128931003

Key Summary Statistics

Cases from any source

Total	2651
Female (%)	1091 (41%)
Male (%)	1560 (59%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	11.2 (8.95,13.45)
Male	22.12 (18.67,25.56)

Incidence stratified by sex

Female	1.99 (1.62,2.35)
Male	4.3 (3.71,4.9)

Incidence stratified by age

Ages 40-44	0.2 (-0.08,0.48)
Ages 45-49	1.04 (0.49,1.58)
Ages 50-54	2.47 (1.7,3.25)
Ages 55-59	2.03 (1.39,2.67)
Ages 60-64	4.43 (3.62,5.23)
Ages 65-69	5.44 (4.41,6.46)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	13 (9,17)	24 (20,28)	47 (42,52)
CALIBER	9 (9,10)	18 (17,20)	41 (39,43)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	16(8,29)	25(17,35)	45(36,56)
Low	19(10,32)	23(16,33)	43(34,53)
Medium	13(6,24)	19(12,29)	48(39,60)
High	11(5,20)	29(21,40)	51(41,63)
Most deprived	8(3,16)	23(16,33)	47(37,59)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	13(10,18)	25(21,30)	46(41,51)
Scotland	13(5,28)	18(10,30)	47(35,62)
Wales	7(1,24)	21(10,37)	54(38,74)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153561, Events=310

Factor	Level	Hazard Ratio	P value
BMI	overweight	0.89 (0.68, 1.17)	0.406
BMI	obese	1.13 (0.84, 1.51)	0.416
BMI	underweight	0 (0, Inf)	0.987
smoking	previous	0.95 (0.75, 1.22)	0.699
smoking	current	1.05 (0.72, 1.55)	0.789
hypertension	yes	1.12 (0.87, 1.45)	0.386

Definition

UK Biobank field id	Description	Code	Value
20001	Cancer code, self-reported	1048	leukaemia
41202	Diagnoses - main ICD10	C91	Lymphoid leukaemia
41202	Diagnoses - main ICD10	C92	Myeloid leukaemia
41202	Diagnoses - main ICD10	C93	Monocytic leukaemia
41202	Diagnoses - main ICD10	C94	Other leukaemias of specified cell type
41202	Diagnoses - main ICD10	C95	Leukaemia of unspecified cell type
41204	Diagnoses - secondary ICD10	C91	Lymphoid leukaemia
41204	Diagnoses - secondary ICD10	C92	Myeloid leukaemia
41204	Diagnoses - secondary ICD10	C93	Monocytic leukaemia
41204	Diagnoses - secondary ICD10	C94	Other leukaemias of specified cell type
41204	Diagnoses - secondary ICD10	C95	Leukaemia of unspecified cell type
40001	Underlying (primary) cause of death: ICD10	C91	Lymphoid leukaemia
40001	Underlying (primary) cause of death: ICD10	C92	Myeloid leukaemia
40001	Underlying (primary) cause of death: ICD10	C93	Monocytic leukaemia
40001	Underlying (primary) cause of death: ICD10	C94	Other leukaemias of specified cell type
40001	Underlying (primary) cause of death: ICD10	C95	Leukaemia of unspecified cell type
40002	Contributory (secondary) causes of death: ICD10	C91	Lymphoid leukaemia
40002	Contributory (secondary) causes of death: ICD10	C92	Myeloid leukaemia
40002	Contributory (secondary) causes of death: ICD10	C93	Monocytic leukaemia
40002	Contributory (secondary) causes of death: ICD10	C94	Other leukaemias of specified cell type
40002	Contributory (secondary) causes of death: ICD10	C95	Leukaemia of unspecified cell type
42040	GP clinical event records	1429.00	H/O: * leukaemia
42040	GP clinical event records	B624000	Leukaemic reticuloendotheliosis of unspecified sites
42040	GP clinical event records	B624300	Leukaemic reticuloend of intra-abdominal lymph nodes
42040	GP clinical event records	B624.00	Leukaemic reticuloendotheliosis
42040	GP clinical event records	B624.11	Leukaemic reticuloendotheliosis
42040	GP clinical event records	B624.12	Hairy cell leukaemia
42040	GP clinical event records	B624z00	Leukaemic reticuloendotheliosis NOS
42040	GP clinical event records	B640000	B-cell acute lymphoblastic leukaemia
42040	GP clinical event records	B640.00	Acute lymphoid leukaemia
42040	GP clinical event records	B641000	B-cell chronic lymphocytic leukaemia
42040	GP clinical event records	B641011	Chronic lymphocytic leukaemia of B-cell type
42040	GP clinical event records	B641100	Clinical stage A chronic lymphocytic leukaemia
42040	GP clinical event records	B641200	Clinical stage B chronic lymphocytic leukaemia
42040	GP clinical event records	B641300	Clinical stage C chronic lymphocytic leukaemia
42040	GP clinical event records	B641.00	Chronic lymphoid leukaemia
42040	GP clinical event records	B641.11	Chronic lymphatic leukaemia
42040	GP clinical event records	B642.00	Subacute lymphoid leukaemia
42040	GP clinical event records	B64..00	Lymphoid leukaemia
42040	GP clinical event records	B64..11	Lymphatic leukaemia
42040	GP clinical event records	B64y100	Prolymphocytic leukaemia
42040	GP clinical event records	B64y200	Adult T-cell leukaemia
42040	GP clinical event records	B64y300	B-cell prolymphocytic leukaemia
42040	GP clinical event records	B64y400	T-cell prolymphocytic leukaemia
42040	GP clinical event records	B64y500	Adult T-cell lymphoma/leukaemia (HTLV-1-associated)
42040	GP clinical event records	B64y.00	Other lymphoid leukaemia
42040	GP clinical event records	B64yz00	Other lymphoid leukaemia NOS
42040	GP clinical event records	B64z.00	Lymphoid leukaemia NOS
42040	GP clinical event records	B650.00	Acute myeloid leukaemia
42040	GP clinical event records	B651100	Chronic myeloid leukaemia, BCR/ABL positive
42040	GP clinical event records	B651200	Chronic neutrophilic leukaemia
42040	GP clinical event records	B651300	Atypical chronic myeloid leukaemia, BCR/ABL negative
42040	GP clinical event records	B651.00	Chronic myeloid leukaemia
42040	GP clinical event records	B651.11	Chronic granulocytic leukaemia
42040	GP clinical event records	B651z00	Chronic myeloid leukaemia NOS
42040	GP clinical event records	B652.00	Subacute myeloid leukaemia
42040	GP clinical event records	B653000	Chloroma
42040	GP clinical event records	B653100	Granulocytic sarcoma
42040	GP clinical event records	B653.00	Myeloid sarcoma
42040	GP clinical event records	B654.00	Acute myeloblastic leukaemia
42040	GP clinical event records	B65..00	Myeloid leukaemia
42040	GP clinical event records	B65y100	Acute promyelocytic leukaemia
42040	GP clinical event records	B65yz00	Other myeloid leukaemia NOS
42040	GP clinical event records	B65z.00	Myeloid leukaemia NOS
42040	GP clinical event records	B660.00	Acute monocytic leukaemia
42040	GP clinical event records	B661.00	Chronic monocytic leukaemia
42040	GP clinical event records	B662.00	Subacute monocytic leukaemia
42040	GP clinical event records	B663.00	Acute monoblastic leukaemia
42040	GP clinical event records	B66..00	Monocytic leukaemia
42040	GP clinical event records	B66..11	Histiocytic leukaemia
42040	GP clinical event records	B66..12	Monoblastic leukaemia
42040	GP clinical event records	B66y.00	Other monocytic leukaemia
42040	GP clinical event records	B66yz00	Other monocytic leukaemia NOS
42040	GP clinical event records	B66z.00	Monocytic leukaemia NOS
42040	GP clinical event records	B670.00	Acute erythraemia and erythroleukaemia
42040	GP clinical event records	B670.11	Di Guglielmo’s disease
42040	GP clinical event records	B672.00	Megakaryocytic leukaemia
42040	GP clinical event records	B672.11	Thrombocytic leukaemia
42040	GP clinical event records	B673.00	Mast cell leukaemia
42040	GP clinical event records	B674.00	Acute panmyelosis
42040	GP clinical event records	B675.00	Acute myelofibrosis
42040	GP clinical event records	B677.00	Myelodysplastic and myeloproliferative disease
42040	GP clinical event records	B67..00	Other specified leukaemia
42040	GP clinical event records	B67y000	Lymphosarcoma cell leukaemia
42040	GP clinical event records	B67y.00	Other and unspecified leukaemia
42040	GP clinical event records	B67yz00	Other and unspecified leukaemia NOS
42040	GP clinical event records	B67z.00	Other specified leukaemia NOS
42040	GP clinical event records	B680.00	Acute leukaemia NOS
42040	GP clinical event records	B681.00	Chronic leukaemia NOS
42040	GP clinical event records	B682.00	Subacute leukaemia NOS
42040	GP clinical event records	B68..00	Leukaemia of unspecified cell type
42040	GP clinical event records	B68y.00	Other leukaemia of unspecified cell type
42040	GP clinical event records	B68z.00	Leukaemia NOS
42040	GP clinical event records	B690.00	Acute myelomonocytic leukaemia
42040	GP clinical event records	B691.00	Chronic myelomonocytic leukaemia
42040	GP clinical event records	B692.00	Subacute myelomonocytic leukaemia
42040	GP clinical event records	B693.00	Juvenile myelomonocytic leukaemia
42040	GP clinical event records	B69..00	Myelomonocytic leukaemia
42040	GP clinical event records	BBr0000	[M]Leukaemia NOS
42040	GP clinical event records	BBr0100	[M]Acute leukaemia NOS
42040	GP clinical event records	BBr0111	[M]Blast cell leukaemia
42040	GP clinical event records	BBr0112	[M]Blastic leukaemia
42040	GP clinical event records	BBr0113	[M]Stem cell leukaemia
42040	GP clinical event records	BBr0200	[M]Subacute leukaemia NOS
42040	GP clinical event records	BBr0300	[M]Chronic leukaemia NOS
42040	GP clinical event records	BBr0400	[M]Aleukaemic leukaemia NOS
42040	GP clinical event records	BBr0.00	[M]Leukaemias unspecified
42040	GP clinical event records	BBr0z00	[M]Leukaemia unspecified, NOS
42040	GP clinical event records	BBr2000	[M]Lymphoid leukaemia NOS
42040	GP clinical event records	BBr2011	[M]Lymphatic leukaemia
42040	GP clinical event records	BBr2100	[M]Acute lymphoid leukaemia
42040	GP clinical event records	BBr2300	[M]Chronic lymphoid leukaemia
42040	GP clinical event records	BBr2500	[M]Prolymphocytic leukaemia
42040	GP clinical event records	BBr2600	[M]Burkitt’s cell leukaemia
42040	GP clinical event records	BBr2700	[M]Adult T-cell leukaemia/lymphoma
42040	GP clinical event records	BBr2.00	[M]Lymphoid leukaemias
42040	GP clinical event records	BBr4000	[M]Erythroleukaemia
42040	GP clinical event records	BBr4.00	[M]Erythroleukaemias
42040	GP clinical event records	BBr4z00	[M]Erythroleukaemia NOS
42040	GP clinical event records	BBr6000	[M]Myeloid leukaemia NOS
42040	GP clinical event records	BBr6011	[M]Granulocytic leukaemia NOS
42040	GP clinical event records	BBr6100	[M]Acute myeloid leukaemia
42040	GP clinical event records	BBr6200	[M]Subacute myeloid leukaemia
42040	GP clinical event records	BBr6300	[M]Chronic myeloid leukaemia
42040	GP clinical event records	BBr6311	[M]Naegeli-type monocytic leukaemia
42040	GP clinical event records	BBr6600	[M]Acute promyelocytic leukaemia
42040	GP clinical event records	BBr6700	[M]Acute myelomonocytic leukaemia
42040	GP clinical event records	BBr6800	[M]Chronic myelomonocytic leukaemia
42040	GP clinical event records	BBr6900	[M]Juvenile myelomonocytic leukaemia
42040	GP clinical event records	BBr6.00	[M]Myeloid leukaemias
42040	GP clinical event records	BBr6z00	[M]Other myeloid leukaemia NOS
42040	GP clinical event records	BBr7000	[M]Basophilic leukaemia
42040	GP clinical event records	BBr9000	[M]Monocytic leukaemia NOS
42040	GP clinical event records	BBrA100	[M]Megakaryocytic leukaemia
42040	GP clinical event records	BBrA111	[M]Thrombocytic leukaemia
42040	GP clinical event records	BBrA400	[M]Hairy cell leukaemia
42040	GP clinical event records	BBrA500	[M]Acute megakaryoblastic leukaemia
42040	GP clinical event records	BBrA.00	[M]Miscellaneous leukaemias
42040	GP clinical event records	BBrAz00	[M]Miscellaneous leukaemia NOS
42040	GP clinical event records	BBr..00	[M]Leukaemias
42040	GP clinical event records	BBrz.00	[M]Leukaemia NOS
42040	GP clinical event records	ByuD500	[X]Other lymphoid leukaemia
42040	GP clinical event records	ByuD600	[X]Other myeloid leukaemia
42040	GP clinical event records	ByuD700	[X]Other monocytic leukaemia
42040	GP clinical event records	ByuD800	[X]Other specified leukaemias
42040	GP clinical event records	ByuD900	[X]Other leukaemia of unspecified cell type
42040	GP clinical event records	ZV10600	[V]Personal history of leukaemia
42040	GP clinical event records	ZV10611	[V]Personal history of lymphoid leukaemia
42040	GP clinical event records	ZV10613	[V]Personal history of myeloid leukaemia
42040	GP clinical event records	ZV67811	[V]Follow-up examination after chemotherapy for leukaemia
42040	GP clinical event records	XE2vi	Acute erythraemia and erythroleukaemia
42040	GP clinical event records	XaYis	Atypical chronic myeloid leukaemia, BCR/ABL negative
42040	GP clinical event records	Xaa8z	[M]Juvenile myelomonocytic leukaemia
42040	GP clinical event records	Xaa1O	Clinical stage B chronic lymphocytic leukaemia
42040	GP clinical event records	BBr00	[M]Leukaemia NOS
42040	GP clinical event records	XaYiK	Myelodysplastic and myeloproliferative disease
42040	GP clinical event records	Xaa1N	Clinical stage A chronic lymphocytic leukaemia
42040	GP clinical event records	Xaa1P	Clinical stage C chronic lymphocytic leukaemia
42040	GP clinical event records	Xa0Sk	Acute myeloblastic leukaemia
42040	GP clinical event records	Xa0S9	T-cell prolymphocytic leukaemia
42040	GP clinical event records	Xa0SD	B-cell acute lymphoblastic leukaemia
42040	GP clinical event records	XaYdL	Juvenile myelomonocytic leukaemia
42040	GP clinical event records	Xa0So	Acute myelofibrosis
42040	GP clinical event records	Xa0T5	B-cell prolymphocytic leukaemia
42040	GP clinical event records	Xa0QP	B-cell chronic lymphocytic leukaemia
42040	GP clinical event records	Xa0Sl	Acute monoblastic leukaemia
40006	Type of cancer: ICD10	C91	Lymphoid leukaemia
40006	Type of cancer: ICD10	C92	Myeloid leukaemia
40006	Type of cancer: ICD10	C93	Monocytic leukaemia
40006	Type of cancer: ICD10	C94	Other leukaemias of specified cell type
40006	Type of cancer: ICD10	C95	Leukaemia of unspecified cell type