| Name |
Lichen planus (lichen_planus) |
| Category |
Skin |
| Sex |
|
| Adult |
Yes |
| UUID |
439420d4-0b24-4543-931d-a355c88a0a03 |
| Definition |
A lichen disease that is located in skin, located in tongue or located in oral mucosa, which presents itself in the form of papules, lesions or rashes. The cause is not known. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
3695 |
| Female (%) |
2392 (65%) |
| Male (%) |
1303 (35%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
90.65 (84.27,97.03) |
| Male |
71.12 (64.95,77.28) |
Incidence stratified by sex
| Female |
7.69 (6.97,8.42) |
| Male |
4.09 (3.52,4.67) |
Incidence stratified by age
| Ages 40-44 |
3.74 (2.53,4.94) |
| Ages 45-49 |
5.44 (4.19,6.69) |
| Ages 50-54 |
4.79 (3.7,5.87) |
| Ages 55-59 |
7.09 (5.89,8.29) |
| Ages 60-64 |
6.76 (5.76,7.77) |
| Ages 65-69 |
6.71 (5.56,7.85) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
66 (58,74) |
98 (91,106) |
140 (132,148) |
| CALIBER |
52 (50,54) |
94 (91,97) |
133 (130,137) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
63(46,84) |
95(79,113) |
132(117,149) |
| Low |
69(52,91) |
100(83,118) |
146(130,164) |
| Medium |
62(46,83) |
93(77,111) |
140(124,158) |
| High |
63(48,82) |
111(94,130) |
133(117,152) |
| Most deprived |
69(54,87) |
94(79,112) |
147(129,168) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
71(62,81) |
107(98,116) |
149(141,158) |
| Scotland |
39(23,60) |
66(50,85) |
89(72,108) |
| Wales |
54(31,89) |
73(52,99) |
117(93,145) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153595, Events=126
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
0.75 (0.51, 1.1) |
0.143 |
| BMI |
obese |
0.53 (0.31, 0.88) |
0.014 |
| BMI |
underweight |
0 (0, Inf) |
0.992 |
| smoking |
previous |
1.05 (0.71, 1.56) |
0.804 |
| smoking |
current |
1.31 (0.76, 2.25) |
0.339 |
| hypertension |
yes |
1.64 (1.09, 2.47) |
0.0186 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1549 |
lichen planus |
| 41202 |
Diagnoses - main ICD10 |
L43 |
Lichen planus |
| 41202 |
Diagnoses - main ICD10 |
L66.1 |
Lichen planopilaris |
| 41204 |
Diagnoses - secondary ICD10 |
L43 |
Lichen planus |
| 41204 |
Diagnoses - secondary ICD10 |
L66.1 |
Lichen planopilaris |
| 40001 |
Underlying (primary) cause of death: ICD10 |
L43 |
Lichen planus |
| 40001 |
Underlying (primary) cause of death: ICD10 |
L66.1 |
Lichen planopilaris |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
L43 |
Lichen planus |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
L66.1 |
Lichen planopilaris |
| 42040 |
GP clinical event records |
M170000 |
Lichen planus actinicus |
| 42040 |
GP clinical event records |
M170100 |
Lichen planus annularis |
| 42040 |
GP clinical event records |
M170200 |
Lichen planus atrophicus |
| 42040 |
GP clinical event records |
M170300 |
Lichen planus bullosus |
| 42040 |
GP clinical event records |
M170400 |
Lichen planus hypertrophicus |
| 42040 |
GP clinical event records |
M170500 |
Lichen planus linearis |
| 42040 |
GP clinical event records |
M170700 |
Lichen planus obtusus |
| 42040 |
GP clinical event records |
M170800 |
Subacute active lichen planus |
| 42040 |
GP clinical event records |
M170900 |
Follicular lichen planus |
| 42040 |
GP clinical event records |
M170.00 |
Lichen planus |
| 42040 |
GP clinical event records |
M170z00 |
Lichen planus NOS |
| 42040 |
GP clinical event records |
M240R00 |
Lichen planopilaris |
| 42040 |
GP clinical event records |
Myu3200 |
[X]Other lichen planus |
| 42040 |
GP clinical event records |
X507b |
Follicular lichen planus |