Infection of liver

Metadata

Name	Infection of liver (liver)
Category	Infections
Sex
Adult	Yes
UUID	beb950e5-d970-49d4-8248-d425802aa1dc
Definition	Infection of liver

Ontologies

SNOMED-CT

235859005

Key Summary Statistics

Cases from any source

Total	3388
Female (%)	1515 (45%)
Male (%)	1873 (55%)

Year first recorded

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Incidence & prevalence

Baseline prevalence stratified by sex

Female	38.9 (34.71,43.09)
Male	47.46 (42.42,52.5)

Incidence stratified by sex

Female	0.9 (0.65,1.15)
Male	1.33 (1.0,1.66)

Incidence stratified by age

Ages 40-44	0.71 (0.18,1.23)
Ages 45-49	0.89 (0.39,1.4)
Ages 50-54	1.53 (0.92,2.14)
Ages 55-59	1.31 (0.79,1.82)
Ages 60-64	0.85 (0.49,1.2)
Ages 65-69	1.21 (0.73,1.69)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

Population	Ages 40-49	Ages 50-59	Ages 60-69
UK Biobank	18 (14,23)	23 (20,28)	17 (14,20)
CALIBER	34 (33,36)	32 (30,33)	22 (21,24)

Stratified by age and Townsend deprivation status

Deprivation status	Ages 40-49	Ages 50-59	Ages 60-69
Least deprived	10(4,20)	16(10,24)	9(5,15)
Low	13(6,25)	12(7,20)	12(8,18)
Medium	11(5,21)	12(7,20)	22(15,30)
High	20(12,32)	27(19,38)	15(10,22)
Most deprived	30(21,43)	48(37,62)	27(20,37)

Stratified by age and country

Country	Ages 40-49	Ages 50-59	Ages 60-69
England	18(14,23)	24(20,28)	17(14,20)
Scotland	17(8,33)	25(15,38)	15(9,24)
Wales	17(6,40)	18(8,35)	13(6,26)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153969, Events=129

Factor	Level	Hazard Ratio	P value
BMI	overweight	1.18 (0.74, 1.86)	0.489
BMI	obese	1.91 (1.2, 3.06)	0.00685
BMI	underweight	0 (0, Inf)	0.995
smoking	previous	1.29 (0.88, 1.87)	0.189
smoking	current	1.41 (0.81, 2.45)	0.23
hypertension	yes	1.93 (1.34, 2.77)	0.000403

Definition

UK Biobank field id	Description	Code	Value
20002	Non-cancer illness code, self-reported	1155	hepatitis
20002	Non-cancer illness code, self-reported	1581	hepatitis d
20002	Non-cancer illness code, self-reported	1582	hepatitis e
20002	Non-cancer illness code, self-reported	1578	hepatitis a
20002	Non-cancer illness code, self-reported	1156	infective/viral hepatitis
41202	Diagnoses - main ICD10	A06.4	Amoebic liver abscess
41202	Diagnoses - main ICD10	B15	Acute hepatitis A
41202	Diagnoses - main ICD10	B16	Acute hepatitis B
41202	Diagnoses - main ICD10	B17	Other acute viral hepatitis
41202	Diagnoses - main ICD10	B18	Chronic viral hepatitis
41202	Diagnoses - main ICD10	B19	Unspecified viral hepatitis
41202	Diagnoses - main ICD10	B25.1	Cytomegaloviral hepatitis
41202	Diagnoses - main ICD10	B58.1	Toxoplasma hepatitis
41202	Diagnoses - main ICD10	B67.0	Echinococcus granulosus infection of liver
41202	Diagnoses - main ICD10	B67.5	Echinococcus multilocularis infection of liver
41202	Diagnoses - main ICD10	B67.8	Echinococcosis, unspecified, of liver
41202	Diagnoses - main ICD10	B94.2	Sequelae of viral hepatitis
41202	Diagnoses - main ICD10	K75.0	Abscess of liver
41202	Diagnoses - main ICD10	K77.0	Liver disorders in infectious and parasitic diseases classified elsewhere
41204	Diagnoses - secondary ICD10	A06.4	Amoebic liver abscess
41204	Diagnoses - secondary ICD10	B15	Acute hepatitis A
41204	Diagnoses - secondary ICD10	B16	Acute hepatitis B
41204	Diagnoses - secondary ICD10	B17	Other acute viral hepatitis
41204	Diagnoses - secondary ICD10	B18	Chronic viral hepatitis
41204	Diagnoses - secondary ICD10	B19	Unspecified viral hepatitis
41204	Diagnoses - secondary ICD10	B25.1	Cytomegaloviral hepatitis
41204	Diagnoses - secondary ICD10	B58.1	Toxoplasma hepatitis
41204	Diagnoses - secondary ICD10	B67.0	Echinococcus granulosus infection of liver
41204	Diagnoses - secondary ICD10	B67.5	Echinococcus multilocularis infection of liver
41204	Diagnoses - secondary ICD10	B67.8	Echinococcosis, unspecified, of liver
41204	Diagnoses - secondary ICD10	B94.2	Sequelae of viral hepatitis
41204	Diagnoses - secondary ICD10	K75.0	Abscess of liver
41204	Diagnoses - secondary ICD10	K77.0	Liver disorders in infectious and parasitic diseases classified elsewhere
40001	Underlying (primary) cause of death: ICD10	A06.4	Amoebic liver abscess
40001	Underlying (primary) cause of death: ICD10	B15	Acute hepatitis A
40001	Underlying (primary) cause of death: ICD10	B16	Acute hepatitis B
40001	Underlying (primary) cause of death: ICD10	B17	Other acute viral hepatitis
40001	Underlying (primary) cause of death: ICD10	B18	Chronic viral hepatitis
40001	Underlying (primary) cause of death: ICD10	B19	Unspecified viral hepatitis
40001	Underlying (primary) cause of death: ICD10	B25.1	Cytomegaloviral hepatitis
40001	Underlying (primary) cause of death: ICD10	B58.1	Toxoplasma hepatitis
40001	Underlying (primary) cause of death: ICD10	B67.0	Echinococcus granulosus infection of liver
40001	Underlying (primary) cause of death: ICD10	B67.5	Echinococcus multilocularis infection of liver
40001	Underlying (primary) cause of death: ICD10	B67.8	Echinococcosis, unspecified, of liver
40001	Underlying (primary) cause of death: ICD10	B94.2	Sequelae of viral hepatitis
40001	Underlying (primary) cause of death: ICD10	K75.0	Abscess of liver
40001	Underlying (primary) cause of death: ICD10	K77.0	Liver disorders in infectious and parasitic diseases classified elsewhere
40002	Contributory (secondary) causes of death: ICD10	A06.4	Amoebic liver abscess
40002	Contributory (secondary) causes of death: ICD10	B15	Acute hepatitis A
40002	Contributory (secondary) causes of death: ICD10	B16	Acute hepatitis B
40002	Contributory (secondary) causes of death: ICD10	B17	Other acute viral hepatitis
40002	Contributory (secondary) causes of death: ICD10	B18	Chronic viral hepatitis
40002	Contributory (secondary) causes of death: ICD10	B19	Unspecified viral hepatitis
40002	Contributory (secondary) causes of death: ICD10	B25.1	Cytomegaloviral hepatitis
40002	Contributory (secondary) causes of death: ICD10	B58.1	Toxoplasma hepatitis
40002	Contributory (secondary) causes of death: ICD10	B67.0	Echinococcus granulosus infection of liver
40002	Contributory (secondary) causes of death: ICD10	B67.5	Echinococcus multilocularis infection of liver
40002	Contributory (secondary) causes of death: ICD10	B67.8	Echinococcosis, unspecified, of liver
40002	Contributory (secondary) causes of death: ICD10	B94.2	Sequelae of viral hepatitis
40002	Contributory (secondary) causes of death: ICD10	K75.0	Abscess of liver
40002	Contributory (secondary) causes of death: ICD10	K77.0	Liver disorders in infectious and parasitic diseases classified elsewhere