| Name |
Alcoholic liver disease (liver_alc) |
| Category |
Digestive |
| Sex |
|
| Adult |
Yes |
| UUID |
e7b00392-7c19-4193-87d5-1bb6f53d4068 |
| Definition |
Liver diseases associated with ALCOHOLISM. It usually refers to the coexistence of two or more subentities, i.e., ALCOHOLIC FATTY LIVER; ALCOHOLIC HEPATITIS; and ALCOHOLIC CIRRHOSIS. |
Ontologies
Key Summary Statistics
Cases from any source
| Total |
2141 |
| Female (%) |
466 (22%) |
| Male (%) |
1675 (78%) |
Year first recorded
Cases linked in all UK Biobank sources
Cross-source concordance
Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.
Incidence & prevalence
Baseline prevalence stratified by sex
| Female |
7.19 (5.39,8.99) |
| Male |
32.62 (28.44,36.8) |
Incidence stratified by sex
| Female |
0.7 (0.49,0.92) |
| Male |
4.37 (3.78,4.97) |
Incidence stratified by age
| Ages 40-44 |
1.91 (1.05,2.77) |
| Ages 45-49 |
1.86 (1.13,2.58) |
| Ages 50-54 |
2.41 (1.64,3.18) |
| Ages 55-59 |
2.81 (2.06,3.56) |
| Ages 60-64 |
2.46 (1.86,3.07) |
| Ages 65-69 |
2.36 (1.69,3.04) |
Period prevalence
Methods
Comparison with general population
Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)
| Population |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| UK Biobank |
21 (17,26) |
40 (35,45) |
36 (32,40) |
| CALIBER |
47 (46,49) |
74 (72,77) |
72 (69,75) |
Stratified by age and Townsend deprivation status
| Deprivation status |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| Least deprived |
14(6,26) |
13(7,21) |
25(18,33) |
| Low |
5(1,14) |
20(13,30) |
20(14,28) |
| Medium |
18(10,31) |
23(15,33) |
33(25,43) |
| High |
16(9,28) |
47(36,61) |
39(30,50) |
| Most deprived |
43(32,58) |
92(76,110) |
70(57,85) |
Stratified by age and country
| Country |
Ages 40-49 |
Ages 50-59 |
Ages 60-69 |
| England |
21(17,27) |
41(35,47) |
35(30,39) |
| Scotland |
24(12,42) |
40(27,56) |
48(35,64) |
| Wales |
14(4,36) |
28(15,47) |
33(21,50) |
Risk factors analysis
‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.
Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method
N=153646, Events=402
| Factor |
Level |
Hazard Ratio |
P value |
| BMI |
overweight |
1.07 (0.82, 1.39) |
0.637 |
| BMI |
obese |
2.13 (1.65, 2.77) |
1.06e-08 |
| BMI |
underweight |
0 (0, Inf) |
0.986 |
| smoking |
previous |
1.48 (1.19, 1.85) |
0.000498 |
| smoking |
current |
2.47 (1.87, 3.26) |
1.43e-10 |
| hypertension |
yes |
2.21 (1.8, 2.72) |
5.76e-14 |
Definition
| UK Biobank field id |
Description |
Code |
Value |
| 20002 |
Non-cancer illness code, self-reported |
1604 |
alcoholic liver disease / alcoholic cirrhosis |
| 41202 |
Diagnoses - main ICD10 |
K70 |
Alcoholic liver disease |
| 41204 |
Diagnoses - secondary ICD10 |
K70 |
Alcoholic liver disease |
| 40001 |
Underlying (primary) cause of death: ICD10 |
K70 |
Alcoholic liver disease |
| 40002 |
Contributory (secondary) causes of death: ICD10 |
K70 |
Alcoholic liver disease |
| 42040 |
GP clinical event records |
G852300 |
Oesophageal varices in alcoholic cirrhosis of the liver |
| 42040 |
GP clinical event records |
J610.00 |
Alcoholic fatty liver |
| 42040 |
GP clinical event records |
J611.00 |
Acute alcoholic hepatitis |
| 42040 |
GP clinical event records |
J612000 |
Alcoholic fibrosis and sclerosis of liver |
| 42040 |
GP clinical event records |
J612.00 |
Alcoholic cirrhosis of liver |
| 42040 |
GP clinical event records |
J612.12 |
Laennec’s cirrhosis |
| 42040 |
GP clinical event records |
J613000 |
Alcoholic hepatic failure |
| 42040 |
GP clinical event records |
J613.00 |
Alcoholic liver damage unspecified |
| 42040 |
GP clinical event records |
J617000 |
Chronic alcoholic hepatitis |
| 42040 |
GP clinical event records |
J617.00 |
Alcoholic hepatitis |
| 42040 |
GP clinical event records |
XaBE3 |
Chronic alcoholic hepatitis |
| 42040 |
GP clinical event records |
XE0b4 |
Alcoholic cirrhosis of liver |
| 42040 |
GP clinical event records |
X3072 |
Alcoholic fibrosis and sclerosis of liver |
| 42040 |
GP clinical event records |
X306r |
Alcoholic hepatitis |
| 42040 |
GP clinical event records |
X3073 |
Alcoholic hepatic failure |
| 42040 |
GP clinical event records |
XaC1d |
Oesophageal varices in alcoholic cirrhosis of the liver |