Metadata

Name Lower Respiratory Tract Infections (lrti)
Category Infections
Sex
Adult Yes
UUID f08a8cc4-4e83-4705-a054-2147e72ac473
Definition Lower Respiratory Tract Infections

Ontologies

SNOMED-CT 50417007
FinnGen J10_LOWERINF

Key Summary Statistics

Cases from any source

Total 51771
Female (%) 24291 (47%)
Male (%) 27480 (53%)

Year first recorded

lrti year of first event

Cases linked in all UK Biobank sources

Cross-source concordance

Vertical bars correspond to number of cases per source/intersection; horizontal bars to left correspond to total number of cases per source.

Cross-sourced lrti cases

Incidence & prevalence

Sex and age-stratified incidence and prevalence of lrti

Baseline prevalence stratified by sex

Female 280.19 (269.09,291.3)
Male 347.18 (333.76,360.61)

Incidence stratified by sex

Female 35.15 (33.59,36.72)
Male 51.8 (49.71,53.89)

Incidence stratified by age

Ages 40-44 17.73 (15.08,20.38)
Ages 45-49 19.3 (16.93,21.68)
Ages 50-54 26.49 (23.91,29.07)
Ages 55-59 38.39 (35.56,41.21)
Ages 60-64 52.09 (49.26,54.93)
Ages 65-69 76.94 (72.98,80.91)

Period prevalence

Methods

Comparison with general population

Sex-standardised prevalence from CALIBER study (Kuan et al. 2019)

CALIBER and UKB lrti prevalence comparison for multiple age groups

Population Ages 40-49 Ages 50-59 Ages 60-69
UK Biobank 231 (217,246) 312 (299,326) 543 (527,558)
CALIBER 270 (266,274) 416 (410,422) 754 (746,763)

Stratified by age and Townsend deprivation status

Deprivation status Ages 40-49 Ages 50-59 Ages 60-69
Least deprived 181(151,215) 204(180,230) 385(358,414)
Low 181(151,215) 233(207,262) 475(445,507)
Medium 170(142,203) 299(270,331) 486(455,519)
High 216(187,249) 310(280,342) 562(527,599)
Most deprived 354(319,392) 506(468,545) 865(819,912)

Stratified by age and country

Country Ages 40-49 Ages 50-59 Ages 60-69
England 234(217,251) 305(290,321) 539(523,557)
Scotland 213(174,258) 330(293,371) 549(505,595)
Wales 236(184,298) 351(302,407) 566(511,625)

Risk factors analysis

‘Healthy’ BMI, smoking status ‘never’, or no hypertension (absence of hypertension records) were considered as reference values.

Hazard Ratio (HR) values with P < 0.0002 were considered to show significant association with disease onset after correction for multiple-testing using the Bonferroni method

N=153969, Events=129

Factor Level Hazard Ratio P value
BMI overweight 1.18 (0.74, 1.86) 0.489
BMI obese 1.91 (1.2, 3.06) 0.00685
BMI underweight 0 (0, Inf) 0.995
smoking previous 1.29 (0.88, 1.87) 0.189
smoking current 1.41 (0.81, 2.45) 0.23
hypertension yes 1.93 (1.34, 2.77) 0.000403

Risk factors analysis forest plot

Definition

UK Biobank field id Description Code Value
20002 Non-cancer illness code, self-reported 1498 empyema
20002 Non-cancer illness code, self-reported 1411 lung abscess
20002 Non-cancer illness code, self-reported 1572 whooping cough / pertussis
20002 Non-cancer illness code, self-reported 1398 pneumonia
41202 Diagnoses - main ICD10 A06.5 Amoebic lung abscess
41202 Diagnoses - main ICD10 A15 Respiratory tuberculosis, bacteriologically and histologically confirmed
41202 Diagnoses - main ICD10 A16 Respiratory tuberculosis, not confirmed bacteriologically or histologically
41202 Diagnoses - main ICD10 A20.2 Pneumonic plague
41202 Diagnoses - main ICD10 A21.2 Pulmonary tularaemia
41202 Diagnoses - main ICD10 A22.1 Pulmonary Anthrax
41202 Diagnoses - main ICD10 A31.0 Pulmonary mycobacterial infection
41202 Diagnoses - main ICD10 A37 Whooping cough
41202 Diagnoses - main ICD10 A42.0 Pulmonary actinomycosis
41202 Diagnoses - main ICD10 A43.0 Pulmonary nocardiosis
41202 Diagnoses - main ICD10 B01.2 Varicella pneumonia
41202 Diagnoses - main ICD10 B05.2 Measles complicated by pneumonia
41202 Diagnoses - main ICD10 B25.0 Cytomegaloviral pneumonitis
41202 Diagnoses - main ICD10 B37.1 Pulmonary candidiasis
41202 Diagnoses - main ICD10 B38.0 Acute pulmonary coccidioidomycosis
41202 Diagnoses - main ICD10 B38.1 Chronic pulmonary coccidioidomycosis
41202 Diagnoses - main ICD10 B38.2 Pulmonary coccidioidomycosis, unspecified
41202 Diagnoses - main ICD10 B39.0 Acute pulmonary histoplasmosis capsulati
41202 Diagnoses - main ICD10 B39.1 Chronic pulmonary histoplasmosis capsulati
41202 Diagnoses - main ICD10 B39.2 Pulmonary histoplasmosis capsulati, unspecified
41202 Diagnoses - main ICD10 B40.0 Acute pulmonary blastomycosis
41202 Diagnoses - main ICD10 B40.1 Chronic pulmonary blastomycosis
41202 Diagnoses - main ICD10 B40.2 Pulmonary blastomycosis, unspecified
41202 Diagnoses - main ICD10 B41.0 Pulmonary paracoccidioidomycosis
41202 Diagnoses - main ICD10 B42.0 Pulmonary sporotrichosis
41202 Diagnoses - main ICD10 B44.0 Invasive pulmonary aspergillosis
41202 Diagnoses - main ICD10 B44.1 Other pulmonary aspergillosis
41202 Diagnoses - main ICD10 B45.0 Pulmonary cryptococcosis
41202 Diagnoses - main ICD10 B46.0 Pulmonary mucormycosis
41202 Diagnoses - main ICD10 B58.3 Pulmonary toxoplasmosis
41202 Diagnoses - main ICD10 B59 Pneumocystosis
41202 Diagnoses - main ICD10 B67.1 Echinococcus granulosus infection of lung
41202 Diagnoses - main ICD10 J10.0 Influenza with pneumonia, other influenza virus identified
41202 Diagnoses - main ICD10 J11.0 Influenza with pneumonia, virus not identified
41202 Diagnoses - main ICD10 J12 Viral pneumonia, not elsewhere classified
41202 Diagnoses - main ICD10 J13 Pneumonia due to Streptococcus pneumoniae
41202 Diagnoses - main ICD10 J14 Pneumonia due to Haemophilus influenzae
41202 Diagnoses - main ICD10 J15 Bacterial pneumonia, not elsewhere classified
41202 Diagnoses - main ICD10 J16 Pneumonia due to other infectious organisms, not elsewhere classified
41202 Diagnoses - main ICD10 J17 Pneumonia in diseases classified elsewhere
41202 Diagnoses - main ICD10 J18 Pneumonia, organism unspecified
41202 Diagnoses - main ICD10 J20 Acute bronchitis
41202 Diagnoses - main ICD10 J21 Acute bronchiolitis
41202 Diagnoses - main ICD10 J22 Unspecified acute lower respiratory infection
41202 Diagnoses - main ICD10 J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection
41202 Diagnoses - main ICD10 J44.1 Chronic obstructive pulmonary disease with acute exacerbation, unspecified
41202 Diagnoses - main ICD10 J65 Pneumoconiosis associated with tuberculosis
41202 Diagnoses - main ICD10 J85.0 Gangrene and necrosis of lung
41202 Diagnoses - main ICD10 J85.1 Abscess of lung with pneumonia
41202 Diagnoses - main ICD10 J85.2 Abscess of lung without pneumonia
41202 Diagnoses - main ICD10 J86 Pyothorax
41202 Diagnoses - main ICD10 P23 Congenital pneumonia
41204 Diagnoses - secondary ICD10 A06.5 Amoebic lung abscess
41204 Diagnoses - secondary ICD10 A15 Respiratory tuberculosis, bacteriologically and histologically confirmed
41204 Diagnoses - secondary ICD10 A16 Respiratory tuberculosis, not confirmed bacteriologically or histologically
41204 Diagnoses - secondary ICD10 A20.2 Pneumonic plague
41204 Diagnoses - secondary ICD10 A21.2 Pulmonary tularaemia
41204 Diagnoses - secondary ICD10 A22.1 Pulmonary Anthrax
41204 Diagnoses - secondary ICD10 A31.0 Pulmonary mycobacterial infection
41204 Diagnoses - secondary ICD10 A37 Whooping cough
41204 Diagnoses - secondary ICD10 A42.0 Pulmonary actinomycosis
41204 Diagnoses - secondary ICD10 A43.0 Pulmonary nocardiosis
41204 Diagnoses - secondary ICD10 B01.2 Varicella pneumonia
41204 Diagnoses - secondary ICD10 B05.2 Measles complicated by pneumonia
41204 Diagnoses - secondary ICD10 B25.0 Cytomegaloviral pneumonitis
41204 Diagnoses - secondary ICD10 B37.1 Pulmonary candidiasis
41204 Diagnoses - secondary ICD10 B38.0 Acute pulmonary coccidioidomycosis
41204 Diagnoses - secondary ICD10 B38.1 Chronic pulmonary coccidioidomycosis
41204 Diagnoses - secondary ICD10 B38.2 Pulmonary coccidioidomycosis, unspecified
41204 Diagnoses - secondary ICD10 B39.0 Acute pulmonary histoplasmosis capsulati
41204 Diagnoses - secondary ICD10 B39.1 Chronic pulmonary histoplasmosis capsulati
41204 Diagnoses - secondary ICD10 B39.2 Pulmonary histoplasmosis capsulati, unspecified
41204 Diagnoses - secondary ICD10 B40.0 Acute pulmonary blastomycosis
41204 Diagnoses - secondary ICD10 B40.1 Chronic pulmonary blastomycosis
41204 Diagnoses - secondary ICD10 B40.2 Pulmonary blastomycosis, unspecified
41204 Diagnoses - secondary ICD10 B41.0 Pulmonary paracoccidioidomycosis
41204 Diagnoses - secondary ICD10 B42.0 Pulmonary sporotrichosis
41204 Diagnoses - secondary ICD10 B44.0 Invasive pulmonary aspergillosis
41204 Diagnoses - secondary ICD10 B44.1 Other pulmonary aspergillosis
41204 Diagnoses - secondary ICD10 B45.0 Pulmonary cryptococcosis
41204 Diagnoses - secondary ICD10 B46.0 Pulmonary mucormycosis
41204 Diagnoses - secondary ICD10 B58.3 Pulmonary toxoplasmosis
41204 Diagnoses - secondary ICD10 B59 Pneumocystosis
41204 Diagnoses - secondary ICD10 B67.1 Echinococcus granulosus infection of lung
41204 Diagnoses - secondary ICD10 J10.0 Influenza with pneumonia, other influenza virus identified
41204 Diagnoses - secondary ICD10 J11.0 Influenza with pneumonia, virus not identified
41204 Diagnoses - secondary ICD10 J12 Viral pneumonia, not elsewhere classified
41204 Diagnoses - secondary ICD10 J13 Pneumonia due to Streptococcus pneumoniae
41204 Diagnoses - secondary ICD10 J14 Pneumonia due to Haemophilus influenzae
41204 Diagnoses - secondary ICD10 J15 Bacterial pneumonia, not elsewhere classified
41204 Diagnoses - secondary ICD10 J16 Pneumonia due to other infectious organisms, not elsewhere classified
41204 Diagnoses - secondary ICD10 J17 Pneumonia in diseases classified elsewhere
41204 Diagnoses - secondary ICD10 J18 Pneumonia, organism unspecified
41204 Diagnoses - secondary ICD10 J20 Acute bronchitis
41204 Diagnoses - secondary ICD10 J21 Acute bronchiolitis
41204 Diagnoses - secondary ICD10 J22 Unspecified acute lower respiratory infection
41204 Diagnoses - secondary ICD10 J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection
41204 Diagnoses - secondary ICD10 J44.1 Chronic obstructive pulmonary disease with acute exacerbation, unspecified
41204 Diagnoses - secondary ICD10 J65 Pneumoconiosis associated with tuberculosis
41204 Diagnoses - secondary ICD10 J85.0 Gangrene and necrosis of lung
41204 Diagnoses - secondary ICD10 J85.1 Abscess of lung with pneumonia
41204 Diagnoses - secondary ICD10 J85.2 Abscess of lung without pneumonia
41204 Diagnoses - secondary ICD10 J86 Pyothorax
41204 Diagnoses - secondary ICD10 P23 Congenital pneumonia
40001 Underlying (primary) cause of death: ICD10 A06.5 Amoebic lung abscess
40001 Underlying (primary) cause of death: ICD10 A15 Respiratory tuberculosis, bacteriologically and histologically confirmed
40001 Underlying (primary) cause of death: ICD10 A16 Respiratory tuberculosis, not confirmed bacteriologically or histologically
40001 Underlying (primary) cause of death: ICD10 A20.2 Pneumonic plague
40001 Underlying (primary) cause of death: ICD10 A21.2 Pulmonary tularaemia
40001 Underlying (primary) cause of death: ICD10 A22.1 Pulmonary Anthrax
40001 Underlying (primary) cause of death: ICD10 A31.0 Pulmonary mycobacterial infection
40001 Underlying (primary) cause of death: ICD10 A37 Whooping cough
40001 Underlying (primary) cause of death: ICD10 A42.0 Pulmonary actinomycosis
40001 Underlying (primary) cause of death: ICD10 A43.0 Pulmonary nocardiosis
40001 Underlying (primary) cause of death: ICD10 B01.2 Varicella pneumonia
40001 Underlying (primary) cause of death: ICD10 B05.2 Measles complicated by pneumonia
40001 Underlying (primary) cause of death: ICD10 B25.0 Cytomegaloviral pneumonitis
40001 Underlying (primary) cause of death: ICD10 B37.1 Pulmonary candidiasis
40001 Underlying (primary) cause of death: ICD10 B38.0 Acute pulmonary coccidioidomycosis
40001 Underlying (primary) cause of death: ICD10 B38.1 Chronic pulmonary coccidioidomycosis
40001 Underlying (primary) cause of death: ICD10 B38.2 Pulmonary coccidioidomycosis, unspecified
40001 Underlying (primary) cause of death: ICD10 B39.0 Acute pulmonary histoplasmosis capsulati
40001 Underlying (primary) cause of death: ICD10 B39.1 Chronic pulmonary histoplasmosis capsulati
40001 Underlying (primary) cause of death: ICD10 B39.2 Pulmonary histoplasmosis capsulati, unspecified
40001 Underlying (primary) cause of death: ICD10 B40.0 Acute pulmonary blastomycosis
40001 Underlying (primary) cause of death: ICD10 B40.1 Chronic pulmonary blastomycosis
40001 Underlying (primary) cause of death: ICD10 B40.2 Pulmonary blastomycosis, unspecified
40001 Underlying (primary) cause of death: ICD10 B41.0 Pulmonary paracoccidioidomycosis
40001 Underlying (primary) cause of death: ICD10 B42.0 Pulmonary sporotrichosis
40001 Underlying (primary) cause of death: ICD10 B44.0 Invasive pulmonary aspergillosis
40001 Underlying (primary) cause of death: ICD10 B44.1 Other pulmonary aspergillosis
40001 Underlying (primary) cause of death: ICD10 B45.0 Pulmonary cryptococcosis
40001 Underlying (primary) cause of death: ICD10 B46.0 Pulmonary mucormycosis
40001 Underlying (primary) cause of death: ICD10 B58.3 Pulmonary toxoplasmosis
40001 Underlying (primary) cause of death: ICD10 B59 Pneumocystosis
40001 Underlying (primary) cause of death: ICD10 B67.1 Echinococcus granulosus infection of lung
40001 Underlying (primary) cause of death: ICD10 J10.0 Influenza with pneumonia, other influenza virus identified
40001 Underlying (primary) cause of death: ICD10 J11.0 Influenza with pneumonia, virus not identified
40001 Underlying (primary) cause of death: ICD10 J12 Viral pneumonia, not elsewhere classified
40001 Underlying (primary) cause of death: ICD10 J13 Pneumonia due to Streptococcus pneumoniae
40001 Underlying (primary) cause of death: ICD10 J14 Pneumonia due to Haemophilus influenzae
40001 Underlying (primary) cause of death: ICD10 J15 Bacterial pneumonia, not elsewhere classified
40001 Underlying (primary) cause of death: ICD10 J16 Pneumonia due to other infectious organisms, not elsewhere classified
40001 Underlying (primary) cause of death: ICD10 J17 Pneumonia in diseases classified elsewhere
40001 Underlying (primary) cause of death: ICD10 J18 Pneumonia, organism unspecified
40001 Underlying (primary) cause of death: ICD10 J20 Acute bronchitis
40001 Underlying (primary) cause of death: ICD10 J21 Acute bronchiolitis
40001 Underlying (primary) cause of death: ICD10 J22 Unspecified acute lower respiratory infection
40001 Underlying (primary) cause of death: ICD10 J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection
40001 Underlying (primary) cause of death: ICD10 J44.1 Chronic obstructive pulmonary disease with acute exacerbation, unspecified
40001 Underlying (primary) cause of death: ICD10 J65 Pneumoconiosis associated with tuberculosis
40001 Underlying (primary) cause of death: ICD10 J85.0 Gangrene and necrosis of lung
40001 Underlying (primary) cause of death: ICD10 J85.1 Abscess of lung with pneumonia
40001 Underlying (primary) cause of death: ICD10 J85.2 Abscess of lung without pneumonia
40001 Underlying (primary) cause of death: ICD10 J86 Pyothorax
40001 Underlying (primary) cause of death: ICD10 P23 Congenital pneumonia
40002 Contributory (secondary) causes of death: ICD10 A06.5 Amoebic lung abscess
40002 Contributory (secondary) causes of death: ICD10 A15 Respiratory tuberculosis, bacteriologically and histologically confirmed
40002 Contributory (secondary) causes of death: ICD10 A16 Respiratory tuberculosis, not confirmed bacteriologically or histologically
40002 Contributory (secondary) causes of death: ICD10 A20.2 Pneumonic plague
40002 Contributory (secondary) causes of death: ICD10 A21.2 Pulmonary tularaemia
40002 Contributory (secondary) causes of death: ICD10 A22.1 Pulmonary Anthrax
40002 Contributory (secondary) causes of death: ICD10 A31.0 Pulmonary mycobacterial infection
40002 Contributory (secondary) causes of death: ICD10 A37 Whooping cough
40002 Contributory (secondary) causes of death: ICD10 A42.0 Pulmonary actinomycosis
40002 Contributory (secondary) causes of death: ICD10 A43.0 Pulmonary nocardiosis
40002 Contributory (secondary) causes of death: ICD10 B01.2 Varicella pneumonia
40002 Contributory (secondary) causes of death: ICD10 B05.2 Measles complicated by pneumonia
40002 Contributory (secondary) causes of death: ICD10 B25.0 Cytomegaloviral pneumonitis
40002 Contributory (secondary) causes of death: ICD10 B37.1 Pulmonary candidiasis
40002 Contributory (secondary) causes of death: ICD10 B38.0 Acute pulmonary coccidioidomycosis
40002 Contributory (secondary) causes of death: ICD10 B38.1 Chronic pulmonary coccidioidomycosis
40002 Contributory (secondary) causes of death: ICD10 B38.2 Pulmonary coccidioidomycosis, unspecified
40002 Contributory (secondary) causes of death: ICD10 B39.0 Acute pulmonary histoplasmosis capsulati
40002 Contributory (secondary) causes of death: ICD10 B39.1 Chronic pulmonary histoplasmosis capsulati
40002 Contributory (secondary) causes of death: ICD10 B39.2 Pulmonary histoplasmosis capsulati, unspecified
40002 Contributory (secondary) causes of death: ICD10 B40.0 Acute pulmonary blastomycosis
40002 Contributory (secondary) causes of death: ICD10 B40.1 Chronic pulmonary blastomycosis
40002 Contributory (secondary) causes of death: ICD10 B40.2 Pulmonary blastomycosis, unspecified
40002 Contributory (secondary) causes of death: ICD10 B41.0 Pulmonary paracoccidioidomycosis
40002 Contributory (secondary) causes of death: ICD10 B42.0 Pulmonary sporotrichosis
40002 Contributory (secondary) causes of death: ICD10 B44.0 Invasive pulmonary aspergillosis
40002 Contributory (secondary) causes of death: ICD10 B44.1 Other pulmonary aspergillosis
40002 Contributory (secondary) causes of death: ICD10 B45.0 Pulmonary cryptococcosis
40002 Contributory (secondary) causes of death: ICD10 B46.0 Pulmonary mucormycosis
40002 Contributory (secondary) causes of death: ICD10 B58.3 Pulmonary toxoplasmosis
40002 Contributory (secondary) causes of death: ICD10 B59 Pneumocystosis
40002 Contributory (secondary) causes of death: ICD10 B67.1 Echinococcus granulosus infection of lung
40002 Contributory (secondary) causes of death: ICD10 J10.0 Influenza with pneumonia, other influenza virus identified
40002 Contributory (secondary) causes of death: ICD10 J11.0 Influenza with pneumonia, virus not identified
40002 Contributory (secondary) causes of death: ICD10 J12 Viral pneumonia, not elsewhere classified
40002 Contributory (secondary) causes of death: ICD10 J13 Pneumonia due to Streptococcus pneumoniae
40002 Contributory (secondary) causes of death: ICD10 J14 Pneumonia due to Haemophilus influenzae
40002 Contributory (secondary) causes of death: ICD10 J15 Bacterial pneumonia, not elsewhere classified
40002 Contributory (secondary) causes of death: ICD10 J16 Pneumonia due to other infectious organisms, not elsewhere classified
40002 Contributory (secondary) causes of death: ICD10 J17 Pneumonia in diseases classified elsewhere
40002 Contributory (secondary) causes of death: ICD10 J18 Pneumonia, organism unspecified
40002 Contributory (secondary) causes of death: ICD10 J20 Acute bronchitis
40002 Contributory (secondary) causes of death: ICD10 J21 Acute bronchiolitis
40002 Contributory (secondary) causes of death: ICD10 J22 Unspecified acute lower respiratory infection
40002 Contributory (secondary) causes of death: ICD10 J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection
40002 Contributory (secondary) causes of death: ICD10 J44.1 Chronic obstructive pulmonary disease with acute exacerbation, unspecified
40002 Contributory (secondary) causes of death: ICD10 J65 Pneumoconiosis associated with tuberculosis
40002 Contributory (secondary) causes of death: ICD10 J85.0 Gangrene and necrosis of lung
40002 Contributory (secondary) causes of death: ICD10 J85.1 Abscess of lung with pneumonia
40002 Contributory (secondary) causes of death: ICD10 J85.2 Abscess of lung without pneumonia
40002 Contributory (secondary) causes of death: ICD10 J86 Pyothorax
40002 Contributory (secondary) causes of death: ICD10 P23 Congenital pneumonia